Results 51 to 60 of about 283,147 (286)

Screening of the mitochondrial A1555G mutation in patients with sensorineural hearing loss

Brazilian Journal of Otorhinolaryngology, 2008
Summary: The A1555G mitochondrial mutation is the main alteration associated with aminoglycoside-induced deafness. Aim: to investigate the prevalence of the A1555G mutation in patients sensorineural hearing loss patients with and without aminoglycosides ...
Luciano Pereira Maniglia, Bruna Carolina Lemos Moreira, Magali Aparecida Orate Menezes da Silva, Vânia Belintani Piatto, José Victor Maniglia   +4 more
doaj   +1 more source

Inhibition of the PP2A activity by the histone chaperone ANP32B is long-range allosterically regulated by respiratory cytochrome c

Redox Biology, 2021
Repair of injured DNA relies on nucleosome dismantling by histone chaperones and de-phosphorylation events carried out by Protein Phosphatase 2A (PP2A).
Francisco Rivero-Rodríguez, Antonio Díaz-Quintana, Alejandro Velázquez-Cruz, Katiuska González-Arzola, Maria P. Gavilan, Adrián Velázquez-Campoy, Rosa M. Ríos, Miguel A. De la Rosa, Irene Díaz-Moreno   +8 more
doaj   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

Unique electron transfer system of cytochrome P450 monooxygenase includes a mechanism of fatty acid β-oxidation

Communications Biology
Cytochrome P450 comprises a group of monooxygenases that hydroxylate xenobiotics and natural compounds with diverse electron transfer systems. Here we identify a natural fusion protein of cytochrome (Cyt) b 5 and Cyt b 5 reductase (CBBR) that transfers ...
Saito Kojima, Kyosei Shinji, Hana Namiki, Kouta Suzuki, Motoyuki Shimizu, Chihiro Kadooka, Nozomi Katsuki, Shunsuke Masuo, Madoka Amahisa, Yuki Doi, Norio Takeshita, Naoki Takaya   +11 more
doaj   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

Burmoniscus dasystylus Nunomura, 2003 (Crustacea, Isopoda, Oniscidea) is a junior synonym of Burmoniscus mauritiensis (Taiti & Ferrara, 1983)

Journal of Asia-Pacific Biodiversity
To confirm the taxonomic status of Burmoniscus dasystylus Nunomura, 2003, we observed the holotype and conducted molecular analyses based on the mitochondrial cytochrome c oxidase subunit I gene sequences.
Shigenori Karasawa, Yan Tao
doaj   +1 more source

Molecular dynamics simulations and hydrogen-bonded network dynamics of cytochrome c oxidase from Paracoccus denitrificans [PDF]

, 2004
Cytochrome c oxidase is the terminal enzyme in the respiratory chain of mitochondria and aerobic bacteria. This enzyme ultimately couples electron transfer from cytochrome c to an oxygen molecule with proton translocation across the inner mitochondrial ...
Olkhova, E., Olkhova, Elena
core  

Western blot detection and quantification of cytochrome c protein in mitochondrial and cytosolic fractions of the Saline group and the Polymyxin B group. [PDF]

, 2016
Western blot detection and quantification of cytochrome c protein in mitochondrial and cytosolic fractions of the Saline group and the Polymyxin B group.
Edson Andrade Pessoa (2993853), Luciana Barros de Moura Neiva (2993850), Maria de Fátima Fernandes Vattimo (2993844), Cassiane Dezoti da Fonseca (2993841), Fernanda Teixeira Borges (2993838), Mirian Watanabe (2993847)   +5 more
core   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

EFFECTS OF CYTOCHROME P-450 INDUCER AND INHIBITOR ANTIEPILEPTIC DRUGS ON LIPID PROFILE IN NORMAL AND DIABETIC RABBITS

The Iraqi Journal of Medical Sciences, 2016
Background: Anticonvulsants drugs are a diverse group of pharmacological agents used in the treatment of epileptic seizures are known to inhibit or activate cytochrome p-450 enzymes that play a crucial rule in the metabolic process.
Mohammed A.M. Abdul-Bari, Faruk H. Al-Jawad, Haitham M. Kadhim   +2 more
doaj   +6 more sources