Results 211 to 220 of about 655,985 (330)

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

open access: yesAdvanced Science, EarlyView.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou   +10 more
wiley   +1 more source

An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy

open access: yesAdvanced Science, EarlyView.
This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo   +11 more
wiley   +1 more source

Interconversions between RNS Revealed by Transient Voltammetry with Porphyrin‐Modified Carbon Nanopipettes in Single Living Cells

open access: yesAdvanced Science, EarlyView.
By using porphyrin modified conductive nanopipettes, transient voltammetry can be directly applied to reveal the dynamic and complex electrochemical reactions between the reactive nitrogen species inside the single living cells. Abstract Reactive nitrogen species (RNS) play crucial roles in cellular signaling, but their quantification is very ...
Hongli Cao   +5 more
wiley   +1 more source

On the Heterogeneity of Beef Heart Cytochrome c. II. Some Physico-chemical Properties of the Main Subfractions (Cy I - Cy III). [PDF]

open access: bronze, 1966
Torgeir Flatmark   +7 more
openalex   +1 more source

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