Results 131 to 140 of about 19,855,151 (220)
Mitochondrial respiration and characteristics of skeletal muscles in children with cerebral palsy
Developmental Medicine &Child Neurology, EarlyView.Skeletal muscles utilize numerous mitochondria for energy production needed during muscle contraction. Mitochondria produce this energy through the electron transport chain. After an injury such as ACL‐injury in typically developing children, there is a reduction in muscle mitochondrial respiration and content.
Sudarshan Dayanidhi +10 more
wiley +1 more source
Transgenic selection and underlying mechanisms in apicomplexan parasites
The FEBS Journal, EarlyView.Transgenic selection markers have driven genetic engineering in apicomplexans, enabling precise, iterative experiments. This review discusses mechanistic details of drug selection markers, strategies for marker recycling, and practical considerations for several clinically relevant parasites.
Swaroop Peddiraju +2 more
wiley +1 more source
Decoding cytochrome c oxidase biogenesis: New insights into copper trafficking [PDF]
, 2011 Acquisition, delivery and incorporation of metals to their respective metalloproteins are important cellular processes. These processes are tightly controlled so that cells are not exposed to free metal concentrations that would lead to harmful oxidative
Ekici, Nursel Seda
core
Rescue of pATOM36‐depleted T. brucei by human MTCH1/2 reveals common features of protein insertases
The FEBS Journal, EarlyView.Human MTCH1 and MTCH2 (with an N‐terminal extension) functionally complement the loss of pATOM36 in T. brucei, indicating that these evolutionarily distant proteins recognize a common set of substrates and share fundamental principles of mitochondrial outer membrane protein insertion. Structural analyses reveal a common hydrophilic cavity, supporting a
Stephan Berger +4 more
wiley +1 more source
, 2012 SummaryHeme plays fundamental roles as cofactor and signaling molecule in multiple pathways devoted to oxygen sensing and utilization in aerobic organisms.
Myers, Richard S +4 more
core +1 more source
Energetic dysregulations in psychotic disorders: Targets for new therapeutics
The FEBS Journal, EarlyView.The present review synthesizes literature documenting aberrant energy production and use, specifically related to mitochondrial and redox dysregulation, in psychotic disorders. Findings from different levels of investigation—genetic, cellular, and in vivo imaging—converge on aberrant energy metabolism as a hallmark of psychotic disorders.
Jacey Anderson +10 more
wiley +1 more source
Anesthesiology and Perioperative SciencePurpose Stroke can cause severe cognitive impairment in patients. Recently, neurogenesis has been proposed as a potential approach to improve cognitive abilities after stroke.
Fuhai Bai +14 more
doaj +1 more source
The Role of Oxidative Stress in Periodontitis
Journal of Periodontal Research, EarlyView.Oxidative stress is involved in multiple chemical reactions that take place in different intracellular organelles: mitochondria, rough endoplasmic reticulum, peroxisomes, autophagy, and aging, and can be influenced by exogenous factors: nutrition, physical activity, psychological status, environmental conditions, microbiome, and drugs.
Pedro Bullon +3 more
wiley +1 more source
Efficiency of RNAi‐based gene silencing in fungi: a meta‐analysis
New Phytologist, EarlyView.Mechanistic interpretation of RNAi efficiency across fungal lifestyles and delivery strategies based on the present meta‐analysis. Summary RNA interference (RNAi) shows great potential to protect crops against fungal diseases, yet reported protection efficiencies vary greatly, and our understanding of the factors responsible for this variance remains ...
Patrick Barth +4 more
wiley +1 more source
Embryonal degreening and seed longevity require plastid LEA proteins
New Phytologist, EarlyView.Working model of how plastidial LEA proteins aid the remodelling of photosynthetic structures during degreening of Arabidopsis seed embryos. LEA42 and LEA48 support thylakoid proteostasis and membrane remodelling in embryonal cells during late seed maturation by maintaining a local physicochemical environment compatible with protein turnover and ...
Dennis Brandt +17 more
wiley +1 more source