A schematic outline of chloroplast DNA tethered to two stacked thylakoids that contain the components of photosynthetic electron transport. Green shapes represent proteins encoded in chloroplast DNA; brown shapes represent proteins encoded in the cell nucleus. ABSTRACT A chloroplast is a subcellular organelle of photosynthesis in plant and algal cells.
John F. Allen
wiley +1 more source
MicroRNAs in Spinal Cord Injury: Molecular and Translational Insights
MicroRNAs (miRNAs) modulate secondary injury cascades following spinal cord injury (SCI), including inflammation, oxidative stress, apoptosis, and demyelination. Key miRNAs such as miR‐21, miR‐124, miR‐219, and miR‐223 exert neuroprotective effects by regulating astrocytic response, axon regeneration, and remyelination.
Seyyedeh Fahimeh Talebi +3 more
wiley +1 more source
Dimethyl fumarate and mitochondrial physiology: implications for neurological disorders. [PDF]
de Oliveira MR.
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The power of many: when genetics met yeasts and high‐throughput
ABSTRACT In recent years, complex technological capabilities have evolved, driven by the need to solve complex and integrative biological questions through global analyses. New equipment allows the scaling up and automation of processes which previously were carried out on a very limited scale.
Víctor A. Tallada, Víctor Carranco
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Exploring mitochondrial functions and dysfunctions in chondrocytes: toward the identification of novel therapies for osteoarthritis. [PDF]
Danet L +3 more
europepmc +1 more source
Targeting Spatiotemporal Heterogeneity of oncomiRNAs: A New Frontier in Cancer Therapy
ABSTRACT Background miRNAs are short RNA transcripts that modulate gene expression after transcription and have emerged as pivotal regulators of cancer biology. A subset, termed oncomiRNAs, functions as oncogenes or tumor suppressors, influencing key cellular events such as cell growth, programmed cell death, neovascularization, tissue invasion, and ...
T. Jeethy Ram, Muralee Damodaran
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Harnessing Repurposed Drugs to Enhance Temozolomide Efficacy in Glioblastoma
ABSTRACT Background Glioblastoma (GB) is the most aggressive primary malignant brain tumor in adults and remains associated with poor survival despite surgical resection followed by radiotherapy and temozolomide (TMZ) chemotherapy. Intrinsic and acquired resistance to TMZ, including MGMT‐dependent DNA repair and activation of pro‐survival pathways ...
Ali Nakhaei +5 more
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Mitochondrial Homeostasis in Pancreatic β Cell Function: Mechanisms and Therapeutic Targets for Diabetes. [PDF]
Li R +5 more
europepmc +1 more source
Mesenchymal stem cell‐derived exosomes (MSC‐sEVs) show preclinical promise for cardiac repair via anti‐inflammatory, anti‐apoptotic, pro‐angiogenic and anti‐fibrotic effects. However, translational hurdles remain, including non‐standardized isolation, unvalidated potency assays, incomplete GMP manufacturing, and lack of completed Phase II/III trials ...
Sakhavat Abolhasani +2 more
wiley +1 more source
Advancing the frontiers of phytotherapy: a comprehensive review of botanical interventions targeting mitochondrial quality control to ameliorate endometriosis. [PDF]
Ye X +7 more
europepmc +1 more source

