Results 51 to 60 of about 279,218 (267)

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

The dynamics of oxidoreductase expression in the liver during experimental peritonitis and the role of p38 MAPK inhibition

Acta Biomedica Scientifica
Background. Oxidative stress is crucial in the pathogenesis of endogenous intoxication syndrome in acute surgical abdominal pathology. The enzyme systems of oxidative phosphorylation and cytochrome reductase are vital for hepatocyte energy potential ...
M. G. Shurygin, I. A. Shurygina, E. E. Chepurnyh, N. N. Dremina   +3 more
doaj   +1 more source

Study the Association of Nucleotide Polymorphisms in Platelet Receptor and Cytochrome P450 Genes with the Development of Resistance to Antiplatelet Drugs in Patients with Coronary Artery Disease

Рациональная фармакотерапия в кардиологии, 2022
Aim. To study the association of nucleotide polymorphisms in platelet receptor and cytochrome P450 genes with the development of resistance to antiplatelet drugs in CHD patients.Material and Methods.
K. S. Semashchenko, T. S. Mongush, A. A. Kosinova, T. N. Subbotina, Y. I. Grinshtein   +4 more
doaj   +1 more source

Charged Amino Acid Substitutions Affect Conformation of Neuroglobin and Cytochrome c Heme Groups

Current Issues in Molecular Biology
Neuroglobin (Ngb) is a cytosolic heme protein that plays an important role in protecting cells from apoptosis through interaction with oxidized cytochrome c (Cyt c) released from mitochondria. The interaction of reduced Ngb and oxidized Cyt c is accompanied by electron transfer between them and the reduction in Cyt c.
Marina A. Semenova, Zhanna V. Bochkova, Olga M. Smirnova, Georgy V. Maksimov, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Nadezda A. Brazhe, Rita V. Chertkova   +7 more
openaire   +3 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Molecular phylogenetic relationship of the subfamily Nymphalinae (Lepidoptera: Nymphalidae) in Myanmar, inferred from mitochondrial gene sequences

Journal of Asia-Pacific Biodiversity, 2017
Phylogenetic relationships for 19 species of the subfamily Nymphalinae were inferred using 607 bp of cytochrome oxidase subunit I. The average base composition of cytochrome oxidase subunit I sequences was 37.9% T, 15.7% C, 31.5% A, and 14.9% G, showing ...
Nan Zarchi Win, Eun Young Choi, Jinyoung Park, Jong Kyun Park   +3 more
doaj   +1 more source

Subunits of Bakers' Yeast Cytochrome b₂ (l‐Lactate Cytochrome c Oxidoreductase) [PDF]

European Journal of Biochemistry, 1971
1.1 to 1.4 residues of lysine were found as N‐terminal amino acid in crystallized cytochrome b2, 1 residue of alanine and variable amounts of lysine as C‐terminal amino acids. Examination of the end groups of the purified S‐carboxymethylated subunits showed that, besides lysine at the N‐terminus in both chains, alanine at the C‐terminal of the light ...
F, Lederer, C, Jacq
openaire   +2 more sources

Identification of functional murine mitochondrial formyl peptides and their effects on myeloid‐derived suppressor cell generation

FEBS Open Bio, EarlyView.
We first identified functional murine mitochondrial N‐formyl peptides (MT‐FPs) and investigated their effects on the in vitro myeloid‐derived suppressor cell (MDSC) generation from bone marrow cells. We demonstrated that MT‐FPs acted directly on bone marrow cells to promote MDSC generation and modulated the polymorphonuclear (PMN)‐MDSC/monocyte (M ...
Miyako Ozawa, Saori Kagoshima, Akira Yamada   +2 more
wiley   +1 more source

Protective Effect of Demethylation Treatment on Cigarette Smoke Extract–Induced Mouse Emphysema Model

Journal of Pharmacological Sciences, 2013
In the present study, we explored the effects of demethylation in a cigarette smoke extract (CSE)-induced mouse emphysema model. Animals were randomly assigned to the control group, CSE group, 5-aza-2′-deoxycytidine (AZA) group, and CSE+AZA group (n = 10
Hongliang Zhang, Ping Chen, Huihui Zeng, Yan Zhang, Hong Peng, Yan Chen, Zhihui He   +6 more
doaj   +1 more source