Emerging perspectives on cytoglobin, beyond NO dioxygenase and peroxidase
Redox Biology, 2020 Cytoglobin is an evolutionary ancient hemoglobin with poor functional annotation. Rather than constrained to penta coordination, cytoglobin's heme iron may exist either as a penta or hexacoordinated arrangement when exposed to different intracellular ...
Clinton Mathai +3 more
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Neuroglobin and cytoglobin: two new members of globin family [PDF]
Revista Brasileira de Hematologia e Hemoterapia, 2011 The globin family has long been defined by myoglobin and hemoglobin, proteins with the functions of oxygen storage and transportation, respectively. Recently, two new members of this family were discovered: neuroglobin present in neurons and retinal ...
Priscilla Tosqui +1 more
doaj +6 more sources
Distribution of cytoglobin in the mouse brain [PDF]
Frontiers in Neuroanatomy, 2016 Cytoglobin (Cygb) is a vertebrate globin with so far poorly defined function. It is expressed in the fibroblast cell-lineage but has also been found in neurons.
Stefan eReuss +4 more
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Melanoma transition is frequently accompanied by a loss of cytoglobin expression in melanocytes: a novel expression site of cytoglobin. [PDF]
PLoS ONE, 2014 The tissue distribution and function of hemoglobin or myoglobin are well known; however, a newly found cytoglobin (CYGB), which also belongs to the globin family, remains to be characterized.
Yoshihiko Fujita +8 more
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Insights into the function of cytoglobin. [PDF]
Biochem Soc Trans, 2023 Since its discovery in 2001, the function of cytoglobin has remained elusive. Through extensive in vitro and in vivo research, a range of potential physiological and pathological mechanisms has emerged for this multifunctional member of the hemoglobin family.
Reeder BJ.
europepmc +4 more sources
Transcriptomic and de novo proteomic analyses of organotypic entorhino-hippocampal tissue cultures reveal changes in metabolic and signaling regulators in TTX-induced synaptic plasticity [PDF]
Molecular BrainUnderstanding the mechanisms of synaptic plasticity is crucial for elucidating how the brain adapts to internal and external stimuli. A key objective of plasticity is maintaining physiological activity states during perturbations by adjusting synaptic ...
Maximilian Lenz +7 more
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Cytoglobin overexpression facilitates proliferation and migration of vascular smooth muscle cells [PDF]
Archives of Biological Sciences, 2020 Cytoglobin, a recently discovered globin, is expressed in vascular smooth muscle cells (VSMCs). Loss of cytoglobin provides a protective effect on vascular reconstruction but the effect of its overexpression is unclear.
Li Lei +5 more
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Protection from intracellular oxidative stress by cytoglobin in normal and cancerous oesophageal cells. [PDF]
PLoS ONE, 2012 Cytoglobin is an intracellular globin of unknown function that is expressed mostly in cells of a myofibroblast lineage. Possible functions of cytoglobin include buffering of intracellular oxygen and detoxification of reactive oxygen species.
Fiona E McRonald +2 more
doaj +1 more source
Hyperthermal stability of neuroglobin and cytoglobin [PDF]
The FEBS Journal, 2005 Neuroglobin (Ngb) and cytoglobin (Cygb), recent additions to the globin family, display a hexa‐coordinated (bis‐histidyl) heme in the absence of external ligands. Although these proteins have the classical globin fold they reveal a very high thermal stability with a melting temperature (Tm) of 100 °C for Ngb and 95 °C for Cygb.
Hamdane, Djemel +7 more
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Cytoglobin conformations and disulfide bond formation [PDF]
The FEBS Journal, 2010 The oligomeric state and kinetics of ligand binding were measured for wild‐type cytoglobin. Cytoglobin has the classical globin fold, with an extension at each extremity of about 20 residues. The extended length of cytoglobin leads to an ambiguous interpretation of its oligomeric state. Although the hydrodynamic diameter corresponds to that of a dimer,
Lechauve, Christophe +7 more
openaire +4 more sources