Results 51 to 60 of about 2,444 (195)

Primary Alcohol-Activated Human and Mouse Hepatic Stellate Cells Share Similarities in Gene-Expression Profiles. [PDF]

, 2020
Alcoholic liver disease (ALD) is a leading cause of cirrhosis in the United States, which is characterized by extensive deposition of extracellular matrix proteins and formation of a fibrous scar.
Baglieri, Jacopo, Benner, Chris, Brenner, David, Chen, Yibu, Diggle, Karin, Dorko, Ken, Hosseini, Mojgan, Kisseleva, Tatiana, Lam, Kevin, Liu, Xiao, Meshgin, Nairika, Musallam, Sami G, Pan, Stephanie Q, Presnell, Sharon, Rosenthal, Sara Brin, Tsukamoto, Hidekazu, Wu, Raymond   +16 more
core   +1 more source

The expression of cytoglobin as a prognostic factor in gliomas: a retrospective analysis of 88 patients [PDF]

, 2013
BACKGROUND: Evidence suggests that cytoglobin (Cygb) may function as a tumor suppressor gene. METHODS: We immunohistochemically evaluated the expression of Cygb, phosphatidylinositol-3 kinase (PI-3K), phosphorylated (p)-Akt, Interleukin-6 (IL-6), tumor ...
Guo-Jun Zhang, Hai-Hua Huang, Hong-Wu Xu, Kwan Man, Lan Lin, Mu Li, Wen Zhou, Xiao-Long Wei, Xin-Peng Lin, Yan-Chun Guo, Yue-Jun Huang, Ze-Rui Zhuang, Ze-Yu Xie   +12 more
core   +1 more source

Peroxidase Activity of Human Hemoproteins: Keeping the Fire under Control

Molecules, 2018
The heme in the active center of peroxidases reacts with hydrogen peroxide to form highly reactive intermediates, which then oxidize simple substances called peroxidase substrates.
Irina I. Vlasova
doaj   +1 more source

Cytoglobin regulates blood pressure and vascular tone through nitric oxide metabolism in the vascular wall

Nature Communications, 2017
The gaseous signalling molecule nitric oxide regulates vascular tone. Here, the authors show that nitric oxide is degraded by the enzyme cytoglobin in the vascular wall, and that mice lacking cytoglobin have reduced blood pressure and are less sensitive ...
Xiaoping Liu, Mohamed A. El-Mahdy, James Boslett, Saradhadevi Varadharaj, Craig Hemann, Tamer M. Abdelghany, Raed S. Ismail, Sean C. Little, Danlei Zhou, Le Thi Thanh Thuy, Norifumi Kawada, Jay L. Zweier   +11 more
doaj   +1 more source

Cytoglobin inhibits non-thermal plasma-induced apoptosis in melanoma cells through regulation of the NRF2-mediated antioxidant response

Redox Biology, 2022
Melanoma arises from pigment-producing cells called melanocytes located in the basal layers of the epidermis of the skin. Cytoglobin (CYGB) is a ubiquitously expressed hexacoordinated globin that is highly enriched in melanocytes and frequently ...
Joey De Backer, Abraham Lin, Wim Vanden Berghe, Annemie Bogaerts, David Hoogewijs   +4 more
doaj   +1 more source

Cytoglobin Overexpression Protects against Damage-Induced Fibrosis

Molecular Therapy, 2006
Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide.
Chen, M, Harrison, PM, Xu, R, Tsui, Ty, Li, L, Fung, PCW, Cheung, Pt, Wang, G, Li, H, Diao, Y, Krissansen, GW, Xu, S, Farzaneh, F   +12 more
openaire   +4 more sources

Cytoglobin Attenuates Neuroinflammation in Lipopolysaccharide-Activated Primary Preoptic Area Cells via NF-κB Pathway Inhibition

Frontiers in Molecular Neuroscience, 2019
Cytoglobin (Cygb) is a hexacoordinate protein, associated with the transport of oxygen, nitric oxide scavenging, tumor suppression and protection against oxidative stress and inflammation.
Bruna R. B. Gomes, Gabriela Luna S. de Sousa, Daniela Ott, Jolanta Murgott, Marcelo V. de Sousa, Paulo E. N. de Souza, Joachim Roth, Fabiane H. Veiga-Souza, Fabiane H. Veiga-Souza   +8 more
doaj   +1 more source

Intermediate Tyrosyl Radical and Amyloid Structure in Peroxide-Activated Cytoglobin. [PDF]

PLoS ONE, 2015
We characterized the peroxidase mechanism of recombinant rat brain cytoglobin (Cygb) challenged by hydrogen peroxide, tert-butylhydroperoxide and by cumene hydroperoxide. The peroxidase mechanism of Cygb is similar to that of myoglobin.
Juliana C Ferreira, Marcelo F Marcondes, Marcelo Y Icimoto, Thyago H S Cardoso, Aryane Tofanello, Felipe S Pessoto, Erica G A Miranda, Tatiana Prieto, Otaciro R Nascimento, Vitor Oliveira, Iseli L Nantes   +10 more
doaj   +1 more source

Cardiac myoglobin deficit has evolved repeatedly in teleost fishes [PDF]

, 2014
Peer reviewedPublisher ...
Collins MR, Daniel Garcia de la serrana, Daniel J. Macqueen, Ian A. Johnston   +3 more
core   +2 more sources

Negative Correlation between Cytoglobin Expression and Intracellular ROS Levels in Human Skin Keloid Fibroblasts

Indonesian Biomedical Journal, 2019
BACKGROUND: In our previous study, we found higher cytoglobin (Cygb) expression in keloid than normal tissue. Cytoglobin is a new globin family protein which function is still being studied to date.
Fajri Marindra Siregar, Novi Silvia Hardiany, Sri Widia Azraki Jusman   +2 more
doaj   +1 more source