Results 61 to 70 of about 2,444 (195)
Protection by Neuroglobin Expression in Brain Pathologies [PDF]
, 2016 Astrocytes play an important role in physiological, metabolic, and structural functions, and when impaired, they can be involved in various pathologies including Alzheimer, focal ischemic stroke, and traumatic brain injury.
Eliana Baez +5 more
core +2 more sources
Neuroglobin, a Novel Target for Endogenous Neuroprotection against Stroke and Neurodegenerative Disorders [PDF]
, 2012 Brain neurons and tissues respond to sublethal injury by activating endogenous protective pathways. Recently, following the failure of a large number of clinical trials for protective strategies against stroke that aim to inhibit a specific ischemia ...
Liu, Jianxiang +4 more
core +2 more sources
EPR analysis of cyanide complexes of wild-type human neuroglobin and mutants in comparison to horse heart myoglobin [PDF]
, 2014 Electron paramagnetic resonance (EPR) data reveal large differences between the ferric (C-)cyanide complexes of wild-type human neuroglobin (NGB) and its H64Q and F28L point mutants and the cyanide complexes of mammalian myo-and haemoglobin.
Dewilde, Sylvia +4 more
core +1 more source
Cytoglobin Interactions with Hydrophobic Probe 1,8-ANS [PDF]
Biophysical Journal, 2013 Cytoglobin (Cygb) is small heme protein that belongs to the hexa-coordinate hemoglobin family. Cygb is over-expressed in fibrosis and neurodegenerative disorders, whereas it is down-regulated in some types of cancer including head and neck cancer. A recent report indicates that Cygb binds sodium oleate, which promotes conformational transition from ...
Astudillo, Luisana +5 more
openaire +1 more source
Influence of temperature on the topological features of inner cavities in cytoglobin [PDF]
, 2015 Cytoglobin (Cygb) is a novel member of the globin family in man, but there is no clear evidence about its biological function. Cygb exhibits a highly complex ligand rebinding kinetics, which agrees with the structural plasticity of the inner cavities ...
Bidon-Chanal, Axel +2 more
core
Immobilization of proteins in silica gel: Biochemical and biophysical properties [PDF]
, 2015 The development of silica-based sol-gel techniques compatible with the retention of protein structure and function started more than 20 years ago, mainly for the design of biotechnological devices or biomedical applications.
Abbruzzetti, S +8 more
core +1 more source
Cancer Science, Volume 117, Issue 3, Page 670-682, March 2026.SPP1 was identified as a key driver of intratumoral fibrosis and hepatocellular carcinoma (HCC) progression through transcriptomic, histological, and functional analyses. Mechanistically, SPP1 promotes HSC activation and fibrosis via the SPP1–CD44–GLI1 axis, and pharmacologic inhibition of Hedgehog signaling effectively reduces tumor growth and ...
Atsushi Nara +16 more
wiley +1 more source
Identification of a novel distal regulatory element of the human Neuroglobin gene by the chromosome conformation capture approach [PDF]
, 2017 Neuroglobin (NGB) is predominantly expressed in the brain and retina. Studies suggest that NGB exerts protective effects to neuronal cells and is implicated in reducing the severity of stroke and Alzheimer's disease.
Chan, G.C.F. (Godfrey Chi Fung) +8 more
core +2 more sources
Histology and histopathology, 2011 Cytoglobin/stellate cell activation-associated protein (Cygb/STAP), a hemoprotein, functions as part of an O2 reservoir with protective effects against oxidative stress in hepatic stellate cells. Heterogeneous expression of the neural cell adhesion molecule (NCAM)+ and/or α-smooth muscle actin (αSMA)+ has been noted in subepithelial myofibroblasts and ...
Okayasu, Isao +7 more
openaire +3 more sources
Probing the Role of Cytoglobin's Extended Termini [PDF]
Biophysical Journal, 2015 Cytoglobin (Cygb) is a hexacoordinated heme protein that is expressed ubiquitously in vertebrate tissues. The physiological function of Cygb remains unknown; however it has been proposed to have a role in oxygen sensing, lipid peroxidation and NO metabolism. Structurally, Cygb has a unique feature among vertebrate globins including extended, disordered
Antonija, Tangar, Tangar, Antonija
openaire +2 more sources