Results 1 to 10 of about 1,308,694 (239)

Association of the IL-10 gene family locus on chromosome 1 with juvenile idiopathic arthritis (JIA) [PDF]

, 2012
The cytokine IL-10 and its family members have been implicated in autoimmune diseases and we have previously reported that genetic variants in IL-10 were associated with a rare group of diseases called juvenile idiopathic arthritis (JIA). The aim of this
Bryant, A, BSPAR study group,, Childhood Arthritis Prospective Study (CAPS),, Childhood Arthritis Response to Medication Study (CHARMS),, Forabosco, P, Hamaoui, R, Hinks, A, Lewis, CM, Omoyinmi, E, Thomson, W, Ursu, S, Wedderburn, LR, Woo, P   +12 more
core   +12 more sources

Targeting cellular calcium homeostasis to prevent cytokine-mediated beta cell death [PDF]

, 2017
Pro-inflammatory cytokines are important mediators of islet inflammation, leading to beta cell death in type 1 diabetes. Although alterations in both endoplasmic reticulum (ER) and cytosolic free calcium levels are known to play a role in cytokine ...
Abreu, Damien, Clark, Amy L, Kanekura, Kohsuke, Lavagnino, Zeno, Mahadevan, Jana, Piston, David W, Semenkovich, Clay F, Spears, Larry D, Urano, Fumihiko, Yagi, Takuya   +9 more
core   +2 more sources

Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]

, 2017
IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri, Dent, Alexander L., Hummel, Sarah A., Janga, Sarath Chandra, Kaplan, Mark H., Khan, Ibrahim, Meuris, Brice, Olson, Matthew R., Ulrich, Benjamin J.   +8 more
core   +1 more source

Global landscape of mouse and human cytokine transcriptional regulation [PDF]

, 2018
Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit ...
Fuxman Bass, Juan Ignacio, Gan, Kok Ann, Imedio, Alvaro Dafonte, Martinez, Melissa, Mehta, Shivani, Pro, Sebastian Carrasco, Santoso, Clarissa Stephanie, Sereda, Rebecca, Sewell, Jared Allan   +8 more
core   +1 more source

Cytokines and Disease [PDF]

Mediators of Inflammation, 2014
Recent evidence in biology and medicine has expanded the knowledge of cytokines function in many disease states and conditions as well as the severe adverse effects implicated in the escalated production associated with specific disease conditions.
Arkadiusz Orzechowski, Agueda A. Rostagno, Sabina Pucci, Gilles Chiocchia   +3 more
openaire   +5 more sources

Reconsidering Res Judicata: A Comparative Perspective [PDF]

, 2011
We aimed to prospectively investigate the paternal antigen-induced cytokine secretion by peripheral blood mononuclear cells (PBMCs) in response to hormone treatment in women undergoing in vitro fertilisation (IVF) and to examine the predictive value of ...
Berg, Göran, Ekerfelt, Christina, Ernerudh, Jan, Jablonowska, Barbara, Jenmalm, Maria C., Jonsson, Yvonne, Persson, Marie   +6 more
core   +3 more sources

Engineering cytokines and cytokine circuits

Science, 2020
Learning to speak the secret language of immune cells could improve ...
Wendell A. Lim, Aileen W. Li
openaire   +4 more sources

IL-21 receptor expression in human tendinopathy [PDF]

, 2014
The pathogenetic mechanisms underlying tendinopathy remain unclear, with much debate as to whether inflammation or degradation has the prominent role.
Campbell, Abigail L., Fazzi, Umberto G., Kerr, Shauna C., Leach, William J., Millar, Neal L., Murrell, George A.C., Reilly, James H., Rooney, Brian P., Smith, Nicola C.   +8 more
core   +2 more sources

Influence of Cytokines and Autologous Lymphokine-Activated Killer Cells on Leukemic Bone Marrow Cells and Colonies in AML [PDF]

, 2001
We have already shown that cytokine cocktails (IL-1 beta, IL-3, IL-6, SCF, GM-CSF) and/or lymphokine-activated killer (LAK) cells can reduce the amounts of clonal, CD34-positive mononuclear bone marrow cells (BM-MNC) in acute myeloid leukemia (AML).
Braun, Susanne Walburg, Gerhartz, Helmut Heinrich, Schmetzer, Helga Maria   +2 more
core   +1 more source

Salivary cytokine panel indicative of non-small cell lung cancer. [PDF]

, 2018
Objective To develop a combinatorial panel of salivary cytokines that manifests the presence of non-small cell lung cancer (NSCLC) that will eventually improve prognosis by facilitating the early diagnosis and management of this common cancer. Methods We
Koizumi, Tomonobu, Shetty, Vivek, Yamaguchi, Masaki   +2 more
core   +3 more sources