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The Effects of Post-Mating Administration of Anti-IL-10 and Anti-TGFß on Conception Rates in Mice [PDF]
International Journal of Fertility and Sterility, 2015 Background In fertility studies, it has been shown that transforming growth factor β (TGFβ) and interlukin 10 (IL-10) play very important roles in implantation, maternal immune tolerance, placentation and fetal development, and the release beginning of ...
Ali Risvanli, Ahmet Godekmerdan
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Ginger and Its Constituents: Role in Prevention and Treatment of Gastrointestinal Cancer
Gastroenterology Research and Practice, 2015 Gastrointestinal (GI) cancer, a cancer of different organs of the digestive system, is one of the most common cancers around the world. The incidence and death rate of some of these cancers are very high.
Sahdeo Prasad, Amit K. Tyagi
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Tuning the Cytokine Responses: An Update on Interleukin (IL)-4 and IL-13 Receptor Complexes
Frontiers in Immunology, 2018 Interleukin (IL)-4 and IL-13 are related cytokines that regulate many aspects of allergic inflammation. They play important roles in regulating the responses of lymphocytes, myeloid cells, and non-hematopoietic cells.
Ilkka S. Junttila, Ilkka S. Junttila
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Scientific ReportsCastleman disease (CD) is a rare hematologic disorder characterized by pathologic lymph node changes and a range of symptoms due to excessive cytokine production.
Ira Miller +6 more
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Retrovirus Entry by Endocytosis and Cathepsin Proteases
Advances in Virology, 2012 Retroviruses include infectious agents inducing severe diseases in humans and animals. In addition, retroviruses are widely used as tools to transfer genes of interest to target cells.
Yoshinao Kubo +4 more
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Anti-interleukin-6 monoclonal antibody for cytokine storm in COVID-19
Annals of Thoracic Medicine, 2020 Novel coronavirus disease 2019 (COVID-19) is known to cause severe pneumonia and acute respiratory distress syndrome which may lead to death. Several treatments have been tested in the race to find a treatment regimen for this deadly viral infection ...
Steven Douedi +2 more
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Effect of Punica granatum Extract Gel on Gingival Crevicular Fluid Levels of Interleukin-1β, Interleukin-8 and CCL28 Levels: Randomised Controlled Clinical Trial [PDF]
Journal of Clinical and Diagnostic Research, 2017 Introduction: Pomegranate (Punica granatum) fruit extract has anti-inflammatory, anti-bacterial, anti-oxidant and immunemodulatory features. Due to increased bacterial resistance to synthetic agents Pomegranate Extract Gel (PEG) could become a natural
Jayant Prakash +4 more
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ISG15 deficiency and increased viral resistance in humans but not mice
Nature Communications, 2016 ISG15 is a ubiquitin-like protein which has important immune-related functions in mice and humans. Here the authors demonstrate that, unlike in mice, human ISG15 stabilizes UPS18 and that ISG15-deficient human cells are more resistant to viral infection.
Scott D. Speer +26 more
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Extraordinary effects of unnatural pairings
eLife, 2017 Engineered molecules based on human cytokines have potential uses in research and medicine.
Alejandro Villarino, John J O'Shea
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eLife, 2017 Cytokine and growth-factor ligands typically signal through homo- or hetero-dimeric cell surface receptors via Janus Kinase (JAK/TYK), or Receptor Tyrosine Kinase (RTK)-mediated trans-phosphorylation.
Ignacio Moraga +6 more
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