Results 41 to 50 of about 115,090 (246)

Case report: Dendritic cell-cytokine induced killer cell therapy in subjects with chronic lymphocytic leukemia and peritoneal cancer

Frontiers in Medicine, 2023
This study aimed to characterize the safety and efficacy of DC-CIK therapy in two patients with previously treated chronic lymphocytic leukemia or peritoneal cancer, respectively.
Brian Mehling, DongCheng Wu, Ellen O’Gorman, Daniel Sheridan, Doreen Santora, Renata Mihályová   +5 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Acute exercise mobilizes NKT-like cells with a cytotoxic transcriptomic profile but does not augment the potency of cytokine-induced killer (CIK) cells

Frontiers in Immunology, 2022
CD3+/CD56+ Natural killer (NK) cell-like T-cells (NKT-like cells) represent <5% of blood lymphocytes, display a cytotoxic phenotype, and can kill various cancers. NKT-like cells can be expanded ex vivo into cytokine-induced killer (CIK) cells, however
Tiffany M. Zúñiga, Forrest L. Baker, Kyle A. Smith, Helena Batatinha, Branden Lau, Michael P. Gustafson, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Emmanuel Katsanis, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson, Richard J. Simpson   +14 more
doaj   +1 more source

Efficacy of cytokine-induced killer cells targeting CD40 and GITR. [PDF]

Oncol Lett, 2019
Since the publication of a novel protocol in 1991, cytokine-induced killer (CIK) cells have shown promising results in the treatment against neoplastic diseases. Despite ongoing preclinical and clinical studies, CIK cell treatment in the context of human monoclonal antibodies targeting tumor-necrosis factor receptors remains overlooked.
Biederbick KD, Schmidt-Wolf IGH.
europepmc   +4 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of dendritic cell-cytokine-induced killer cells in patients with advanced colorectal cancer combined with first-line treatment

World Journal of Surgical Oncology, 2017
Background Surgical resection combined with adjuvant chemotherapy is considered as the gold-standard treatment for advanced colorectal cancer patients. These patients have a poor 5-year survival rate of 5% or less.
Yunqing Xie, Lijie Huang, Luchuan Chen, Xiaowei Lin, Li Chen, Qiuhong Zheng   +5 more
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Researche Advances on CIK Cells and Their Clinical Use in Lung Cancer

Chinese Journal of Lung Cancer, 2011
As the leading cause of cancer-related death among human beings, lung cancer seriously threats peoples’ health all over the world. Cytokine-induced killer cells (CIK) is a new kind of adaptive immune cells characterized by its dramatic proliferation ...
Hu LUO, Xiangdong ZHOU
doaj   +1 more source

Human Cytokine-Induced Memory-Like Natural Killer Cells [PDF]

Journal of Innate Immunity, 2015
Natural killer (NK) cells are innate lymphoid cells that are important for host defense against infection and mediate antitumor responses. Recent reports from several laboratories have identified that NK cells can remember a prior activation event and consequently respond more robustly when restimulated, a property termed innate NK cell memory. NK cell
Melissa M. Berrien-Elliott, Julia A. Wagner, Todd A. Fehniger   +2 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source