Results 121 to 130 of about 7,183,853 (276)

Characterisation of T cell defects in acute myeloid leukaemia [PDF]

, 2009
PhDUnderstanding the immune system in patients with cancer and how it interacts with malignant cells is critical for the development of successful immunotherapeutic strategies at a time when novel cancer treatment approaches are required.
Le Dieu, Helen Rifca
core   +3 more sources

Is COVID-19 acute respiratory distress syndrome-induced consumption leukocytopenia the possible cause of delayed sepsis?

Journal of Indira Gandhi Institute of Medical Sciences
The adaptive immune response is crucial in limiting SARS-CoV-2 infections. The body's immune system becomes hyperinflated when infected organs are not eradicated, which results in a cytokine storm.
Amarjeet Kumar, Abhyuday Kumar, Neeraj Kumar, Kunal Singh, Veena Singh   +4 more
doaj   +1 more source

Improving Clinical Manufacturing of IL-15 Activated Cytokine-Induced Killer (CIK) Cells

Frontiers in Immunology, 2019
Cytokine-induced killer (CIK) cells are an immunotherapeutic approach to combat relapse following allogeneic hematopoietic stem cell transplantation (HSCT) in acute leukemia or myelodysplastic syndrome (MDS) patients. Prompt and sequential administration
Melanie Bremm, Lisa-Marie Pfeffermann, Claudia Cappel, Verena Katzki, Stephanie Erben, Sibille Betz, Andrea Quaiser, Michael Merker, Halvard Bonig, Michael Schmidt, Thomas Klingebiel, Peter Bader, Sabine Huenecke, Eva Rettinger   +13 more
doaj   +1 more source

Radiotherapy Enhances the Oncolytic Efficacy of the Novel Oncolytic Herpesvirus VG161 and Amplifies Its Antitumor Immunity in Breast Cancer

Advanced Science, EarlyView.
RT promotes VG161 replication in BC and its immunostimulatory transgenes expression, which is mediated by the upregulation of GADD34 and HVEM caused by RT. The combination therapy with VG161 and RT increases the abundances of tumor‐infiltrating lymphocytes and elicits potent systemic antitumor immunity, thereby effectively inhibiting local tumors and ...
Lijuan Lyu, Ming Yi, Ji Chen, Zeda Zhao, Ruocen Liao, Yingnan Wang, Shengtao Hu, Jun Ding, Ronghua Zhao, William Jia, Yinan Shen, Yongchang Wei, Kongming Wu, Zhijun Dai   +13 more
wiley   +1 more source

Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis [PDF]

, 2009
Cytotoxic activity of invariant NKT cells in human allergic contact dermatitis Background: The role of cytotoxicity of NKT-cells in the skin is not defined. There are two prototypic skin diseases in which epidermal Keratinocytes (KC) over-express CD1d, a
Balato, Anna
core   +1 more source

Current Status of Gene Engineering Cell Therapeutics

Frontiers in Immunology, 2018
Ex vivo manipulations of autologous patient’s cells or gene-engineered cell therapeutics have allowed the development of cell and gene therapy approaches to treat otherwise incurable diseases.
Aurore Saudemont, Laurent Jespers, Timothy Clay   +2 more
doaj   +1 more source

Optimization of B Cell Responses in Human Immune System Mice Through Organoid Based Screening

Advanced Science, EarlyView.
Human immune system (HIS) mice show limited B cell responses to immunization. Using HIS mouse spleen organoids, this study identifies cytokine combinations and innate immune signals that drive human B cell expansion, differentiation, and class‐switch. Applying these signals in vivo through temporal separation enables antigen‐specific IgG responses and ...
Haiqiao Sun, He Li, Xu Zhu, Zijian Zhang, Deshan Ren, Shuai Ding, Yan Li   +6 more
wiley   +1 more source

Post-operative adjuvant immunotherapy with cytokine-induced killer and dendritic cells for hepatocellular carcinoma: A systematic review and meta-analysis

Asian Journal of Surgery, 2023
Huijun Guo, Yun Meng, Jiangshan Peng, Xiaojun Yang   +3 more
doaj   +1 more source

Biological Characteristics and Antitumor Activity of CIK Cells Activated by Recombinant Human Fibronectin for Human Lung Cancer Cell Lines In Vitro

Chinese Journal of Lung Cancer, 2010
Background and objective The CIK cell is one of the most important means of the adoptive cellular immunotherapy, and it is a hotspot of which to simplify its culture procedure and to promote its inhibition rate.
Jialing WANG, Zhe ZHANG, Sa LIU, Yunfeng YANG, Ying HE, Yuan ZHANG, Tuya WULAN, Hui ZHANG, Weili DU, Shiyong WANG   +9 more
doaj  

Growth of Human Colorectal Cancer SW1116 Cells Is Inhibited by Cytokine-Induced Killer Cells

Clinical and Developmental Immunology, 2011
Previous reports have suggested that treatment with cytokine-induced killer (CIK) cells may benefit patients with various types of tumor. The aim of this study was to evaluate the antitumor effects of CIK cells against the colorectal cancer line SW1116 ...
Yao Wang, Hanren Dai, Hong Li, Haiyan Lv, Tao Wang, Xiaobing Fu, Weidong Han   +6 more
doaj   +1 more source