Results 81 to 90 of about 7,183,853 (276)

Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection. [PDF]

, 2010
BACKGROUND: An appropriate balance between pro-inflammatory and anti-inflammatory cytokines that mediate innate and adaptive immune responses is required for effective protection against human malaria and to avoid immunopathology.
Veenemans, J., Chilongola, Jaffu O, Veenemans, Jacobien, Meijerink, M., Mbugi Erasto V, Huub FJ Savelkoul, Shao John F, Meijerink Marjolein, Savelkoul, H.F.J., Savelkoul, Huub FJ, Hans Verhoef, Matthew McCall, Jaffu O Chilongola, Olomi, Raimos M, McCall Matthew, Raimos M Olomi, Veenemans Jacobien, Shao, J.F., Mbugi, Erasto V, McCall, Matthew, Jeurink, P.V., McCall, M., Verhoef, H., Marjolein Meijerink, Verhoef Hans, Savelkoul, H.F., Chilongola Jaffu O, Erasto V Mbugi, Savelkoul Huub FJ, Chilongola, J.O., John F Shao, Jeurink, Prescilla V, Shao, John F, Olomi, R.M., Jeurink Prescilla V, Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Chilongola, J., Meijerink, Marjolein, Olomi Raimos M, Prescilla V Jeurink   +41 more
core   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Retrospective analysis of the efficacy of cytokine‐induced killer cell immunotherapy combined with first‐line chemotherapy in patients with metastatic colorectal cancer

Clinical & Translational Immunology, 2020
Objectives Fluoropyrimidine‐based chemotherapy regimens are the current first‐line treatment for metastatic colorectal cancer (mCRC); however, the outcome is often unsatisfactory.
Qiu‐Zhong Pan, Jia‐Mei Gu, Jing‐Jing Zhao, Yan Tang, Qi‐Jing Wang, Qian Zhu, Meng‐Jia Song, Yong‐Qiang Li, Jia He, Shi‐Ping Chen, De‐Sheng Weng, Jian‐Chuan Xia   +11 more
doaj   +1 more source

Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells. [PDF]

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) establishes life-long infection by evading clearance by the host immune system. In de novo infection and lytic replication, KSHV escapes cytotoxic T cells and NK cells through downregulation of MHC class-I ...
Nick C. Matthews, Gotch, FM, Frances M. Gotch, Robey, Rebecca C, Bower, Mark, Rebecca C. Robey, Mark Bower, Matthews, Nick C, Goodier, Martin R, Bower, M, Goodier, MR, Robey, RC, Gotch, Frances M, Martin R. Goodier, Matthews, NC   +14 more
core   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

The role of natural killer cells in adaptive immune responses [PDF]

Human natural killer (NK) cells have been shown to respond to numerous pathogenic stimuli, producing IFN-y as well as cytolytic effector molecules such as perforin and granzymes.
Horowitz, Amir
core   +1 more source

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2013
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Gregson, John NS, Gazzard, Brian G, Goodier, Martin R, Kuri-Cervantes, Leticia, Mela, Christopher M, Bower, Mark   +5 more
core   +1 more source

Cytokine-induced killer cells: A novel immunotherapy strategy for leukemia

Oncology Letters, 2014
Cytokine-induced killer (CIK) cells are NK-like T cells derived from peripheral blood mononuclear cells that are co-stimulated and expanded using cytokines for 14-21 days in vitro. CIK cells are a heterogeneous subset of highly-efficient cytotoxic T effector cells that mediate major histocompatibility complex-unrestricted cytotoxicity against a broad ...
YANG, XIN-YU, ZENG, HUI, CHEN, FANG-PING
openaire   +3 more sources

Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma

Scientific Reports
Despite the favorable effects of immunotherapies in multiple types of cancers, its complete success in CNS malignancies remains challenging. Recently, a successful clinical trial of cytokine-induced killer (CIK) cell immunotherapy in patients with ...
Annika Simone Lück, Jingjing Pu, Ahmad Melhem, Matthias Schneider, Amit Sharma, Ingo G. H. Schmidt-Wolf, Jarek Maciaczyk   +6 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source