Efficient killing of radioresistant breast cancer cells by cytokine-induced killer cells [PDF]
Tumor Biology, 2017 Recurrence of breast cancer after radiotherapy may be partly explained by the presence of radioresistant cells. Thus, it would be desirable to develop an effective therapy against radioresistant cells. In this study, we demonstrated the intense antitumor
Qingming Guo +8 more
doaj +4 more sources
Cytokine-Induced Killer Cells [PDF]
Definitions, 2020 A preparation of autologous lymphocytes with potential immunopotentiating and antineoplastic activities. Cytokine-induced killer (CIK) cells are CD3and CD56-positive, non-major histocompatibility complex (MHC)-restricted, natural killer (NK)-like T ...
semanticscholar +2 more sources
Clinical Studies Applying Cytokine-Induced Killer Cells for the Treatment of Renal Cell Carcinoma. [PDF]
Cancers (Basel), 2020 Simple Summary Cytokine-induced killer (CIK) cells are a heterogeneous population of polyclonal T effector cells expanded ex vivo. Here, we updated our last review published in 2012 and provided a synopsis of current 15 clinical studies, including 382 ...
Zhang Y +3 more
europepmc +2 more sources
Altered thymic differentiation and modulation of arthritis by invariant NKT cells expressing mutant ZAP70 [PDF]
Nature Communications, 2018 Invariant natural killer T (iNKT) cells can be subsetted based on their cytokine productions. Here the authors show, using Zap70 mutant mice, that interferon-γ secreting (IFN-γ) iNKT cells may be induced by hampered T cell receptor signallings to help ...
Meng Zhao +10 more
doaj +5 more sources
ERBB2-CAR-Engineered Cytokine-Induced Killer Cells Exhibit Both CAR-Mediated and Innate Immunity Against High-Risk Rhabdomyosarcoma. [PDF]
Front Immunol, 2020 High-risk rhabdomyosarcoma (RMS) occurring in childhood to young adulthood is associated with a poor prognosis; especially children above the age of 10 with advanced stage alveolar RMS still succumb to the disease within a median of 2 years.
Merker M +11 more
europepmc +2 more sources
Increase in Efficacy of Checkpoint Inhibition by Cytokine-Induced-Killer Cells as a Combination Immunotherapy for Renal Cancer. [PDF]
Int J Mol Sci, 2020 Cytokine-induced killer (CIK) cells are heterogeneous, major histocompatibility complex (MHC)-unrestricted T lymphocytes that have acquired the expression of several natural killer (NK) cell surface markers following the addition of interferon gamma (IFN-
Dehno MN +3 more
europepmc +2 more sources
Immunotherapy with dendritic cells and cytokine-induced killer cells for hepatocellular carcinoma: A meta-analysis. [PDF]
World J Gastroenterol, 2019 BACKGROUND Hepatocellular carcinoma (HCC) has been revealed as the second most common cause of cancer-related deaths worldwide. The introduction of cell-based immunotherapy, including dendritic cells (DCs) and cytokine-induced killer cells (CIKs), has ...
Cao J, Kong FH, Liu X, Wang XB.
europepmc +2 more sources
Autologous Cytokine-induced Killer Cells [PDF]
Definitions, 2020 A proprietary formulation of autologous cytokine-induced killer (CIK) T -lymphocytes, with immunopotentiating and antineoplastic activities. T hese CIK cells are generated by ex vivo incubation of autologous peripheral blood lymphocytes with an ...
semanticscholar +2 more sources
Biological Character of RetroNectin Activated Cytokine-Induced Killer Cells [PDF]
Journal of Immunology Research, 2016 Adoptive cell therapy (ACT) using autologous cytokine-induced killer (CIK) cells is a promising treatment for metastatic carcinomas. In this study, we investigated the impact of RetroNectin on the proliferation, phenotype alternation, cytokine secretion,
Lu Han +3 more
doaj +3 more sources
Cytokine Induced Killer (CIK) Cells Based Adoptive Immunotherapy
Journal of Gandaki Medical College, 2018 Cytokine induced killer (CIK) cells has been increasingly used in adoptive immunotherapy against various cancers and viral infections. This review summarizes the basic overview of CIK cells as a therapeutic immunocyte.
S Timalsena, P P Lamichhane
doaj +3 more sources