Results 31 to 40 of about 420,437 (312)

Cytokine-induced killer cells promote antitumor immunity [PDF]

Journal of Translational Medicine, 2013
The number of immune cells, especially dendritic cells and cytotoxic tumor infiltrating lymphocytes (TIL), particularly Th1 cells, CD8 T cells, and NK cells is associated with increased survival of cancer patients. Such antitumor cellular immune responses can be greatly enhanced by adoptive transfer of activated type 1 lymphocytes.
Jiang, J, Wu, C, Lu, B
openaire   +2 more sources

Cytokine-induced memory-like natural killer cells [PDF]

Proceedings of the National Academy of Sciences, 2009
The mammalian immune response to infection is mediated by 2 broad arms, the innate and adaptive immune systems. Innate immune cells are a first-line defense against pathogens and are thought to respond consistently to infection, regardless of previous exposure, i.e., they do not exhibit memory of prior activation.
Megan A, Cooper, Julie M, Elliott, Peter A, Keyel, Liping, Yang, Javier A, Carrero, Wayne M, Yokoyama   +5 more
openaire   +2 more sources

Ten‐year update of the international registry on cytokine‐induced killer cells in cancer immunotherapy

Journal of Cellular Physiology, 2020
Cytokine‐induced killer (CIK) cells represent an exceptional T‐cell population uniting a T cell and natural killer cell‐like phenotype in their terminally differentiated CD3+CD56+ subset, which features non‐MHC‐restricted tumor‐killing activity.
Ying Zhang, I. Schmidt-Wolf
semanticscholar   +1 more source

Human Cytokine-Induced Memory-Like Natural Killer Cells [PDF]

Journal of Innate Immunity, 2015
Natural killer (NK) cells are innate lymphoid cells that are important for host defense against infection and mediate antitumor responses. Recent reports from several laboratories have identified that NK cells can remember a prior activation event and consequently respond more robustly when restimulated, a property termed innate NK cell memory. NK cell
Melissa M. Berrien-Elliott, Julia A. Wagner, Todd A. Fehniger   +2 more
openaire   +2 more sources

Pro-inflammatory signaling by IL-10 and IL-22: bad habit stirred up by interferons? [PDF]

, 2013
Interleukin (IL)-10 and IL-22 are key members of the IL-10 cytokine family that share characteristic properties such as defined structural features, usage of IL-10R2 as one receptor chain, and activation of signal transducer and activator of ...
Mühl, Heiko
core   +5 more sources

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation

Haematologica, 2010
Background Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
Selim Kuçi, Eva Rettinger, Bernhard Voß, Gerrit Weber, Miriam Stais, Hermann Kreyenberg, Andre Willasch, Zyrafete Kuçi, Ewa Koscielniak, Stephan Klöss, Dorothee von Laer, Thomas Klingebiel, Peter Bader   +12 more
doaj   +1 more source

MicroRNA profiling of CD3+CD56+ cytokine-induced killer cells [PDF]

Scientific Reports, 2015
AbstractStudies have proven that IL-2 and IL-15 showed contrasting roles during CIK cells preparation. By employing microarray, we analyzed miRNA expression profiles of PBMC, CIKIL-2 and CIKIL-15. Advanced bioinformatic analyses were performed to explore the key miRNAs which may regulate cell proliferation and anti-tumor activity of CIK.
Wenju Wang, Ruhong Li, Mingyao Meng, Chuanyu Wei, Yanhua Xie, Yayong Zhang, Lihong Jiang, Ruiyi Dong, Chunhui Wang, Yiming Zhong, Fang Yang, Weiwei Tang, Xingfang Jin, Baohua Liu, Zongliu Hou   +14 more
openaire   +2 more sources

Early Investigations and Recent Advances in Intraperitoneal Immunotherapy for Peritoneal Metastasis. [PDF]

, 2018
Peritoneal metastasis (PM) is an advanced stage malignancy largely refractory to modern therapy. Intraperitoneal (IP) immunotherapy offers a novel approach for the control of regional disease of the peritoneal cavity by breaking immune tolerance.
Bowne, Wilbur B., Katz, Steven C., Khalili, Marian, Morano, William F., Richard, Scott D., Thadi, Anusha   +5 more
core   +2 more sources

Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors

Haematologica, 2010
Background Cytokine-induced killer cells are ex vivo-expanded cells with potent antitumor activity. The infusion of cytokine-induced killer cells in patients with acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplant is ...
Virna Marin, Irene Pizzitola, Valentina Agostoni, Greta Maria Paola Giordano Attianese, Helene Finney, Alastair Lawson, Martin Pule, Raphael Rousseau, Andrea Biondi, Ettore Biagi   +9 more
doaj   +1 more source

Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]

, 2017
Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana, Cippitelli, Marco, Fionda, Cinzia, Santoni, Angela, Soriani, Alessandra, Zingoni, Alessandra   +5 more
core   +1 more source