Results 51 to 60 of about 184,390 (149)

Effect of chaetocin on renal cell carcinoma cells and cytokine-induced killer cells

GMS German Medical Science, 2016
We examined the cytotoxic effects of chaetocin on clear cell renal cell carcinoma (ccRCC) cells and the possibility to combine the effects of chaetocin with the effects of cytokine-induced killer cells (CIK) assayed by MTT assay and FACS analysis ...
Rombo, Roman, Weiher, Hans, Schmidt-Wolf, Ingo G.H.   +2 more
doaj   +1 more source

Retrospective analysis of the efficacy of cytokine‐induced killer cell immunotherapy combined with first‐line chemotherapy in patients with metastatic colorectal cancer

Clinical & Translational Immunology, 2020
Objectives Fluoropyrimidine‐based chemotherapy regimens are the current first‐line treatment for metastatic colorectal cancer (mCRC); however, the outcome is often unsatisfactory.
Qiu‐Zhong Pan, Jia‐Mei Gu, Jing‐Jing Zhao, Yan Tang, Qi‐Jing Wang, Qian Zhu, Meng‐Jia Song, Yong‐Qiang Li, Jia He, Shi‐Ping Chen, De‐Sheng Weng, Jian‐Chuan Xia   +11 more
doaj   +1 more source

Differential Targeting of Stem Cells and Differentiated Glioblastomas by NK Cells. [PDF]

, 2015
We have recently shown that Natural Killer (NK) cells control survival and differentiation of Cancer Stem-like Cells (CSCs) through two distinct phenotypes of cytotoxic and anergic NK cells, respectively. In this report, brain CSCs and their serum and NK
Bui, Vickie T, Cacalano, Nicholas, Inagaki, Akihito, Jewett, Anahid, Kasahara, Noriyuki, Man, Yan-Gao, Tseng, Han-Ching   +6 more
core   +1 more source

Cytokine-induced killer cells are type II natural killer T cells

GMS German Medical Science, 2007
Background: Until now, cytokine-induced killer (CIK) cells were assumed to be part of the type I natural killer T (NKT) cell population, but it was not yet investigated if this is correct.
Schmidt-Wolf, Ingo G.H., Strehl, John, Frank, Susanne, Gütgemann, Stefan   +3 more
doaj  

Interactions of Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (TRAIL) with the Immune System: Implications for Inflammation and Cancer [PDF]

, 2019
Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily. TRAIL has historically been distinct from the Fas ligand and TNFα in terms of selective apoptosis induction in tumor cells and has a nearly non ...
Baukloh, Ann-Kathrin, Beyer, Katharina, Kamphues, Carsten, Kotsch, Katja, Sattler, Arne, Stoyanova, Ani   +5 more
core   +1 more source

Immunotherapy in hepatocellular carcinoma: the complex interface between inflammation, fibrosis, and the immune response. [PDF]

, 2019
Hepatocellular carcinoma (HCC) is the third leading cause of cancer deaths worldwide and confers a poor prognosis. Beyond standard systemic therapy with multikinase inhibitors, recent studies demonstrate the potential for robust and durable responses ...
Fong, Lawrence, Keenan, Bridget P, Kelley, Robin K   +2 more
core   +2 more sources

Preclinical evaluation of DC-CIK cells as potentially effective immunotherapy model for the treatment of glioblastoma

Scientific Reports
Despite the favorable effects of immunotherapies in multiple types of cancers, its complete success in CNS malignancies remains challenging. Recently, a successful clinical trial of cytokine-induced killer (CIK) cell immunotherapy in patients with ...
Annika Simone Lück, Jingjing Pu, Ahmad Melhem, Matthias Schneider, Amit Sharma, Ingo G. H. Schmidt-Wolf, Jarek Maciaczyk   +6 more
doaj   +1 more source

Evolution of cell therapy for renal cell carcinoma

Molecular Cancer
Treatment for renal cell carcinoma (RCC) has improved dramatically over the last decade, shifting from high-dose cytokine therapy in combination with surgical resection of tumors to targeted therapy, immunotherapy, and combination therapies.
Yufei Wang, Eloah Rabello Suarez, Gabriella Kastrunes, Najla Santos Pacheco de Campos, Rabia Abbas, Renata Schmieder Pivetta, Nithyassree Murugan, Ghanbar Mahmoodi Chalbatani, Vincent D’Andrea, Wayne A. Marasco   +9 more
doaj   +1 more source

Autologous cytokine-induced killer cell transfusion increases overall survival in advanced pancreatic cancer

Journal of Hematology & Oncology, 2016
Background Advanced pancreatic cancer (PC) has very poor prognosis with present treatments, thus necessitating continued efforts to find improved therapeutic approaches. Both preclinical and preliminary clinical data indicate that cytokine-induced killer
Zibing Wang, Yuqing Liu, Rui’e Li, Yiman Shang, Yong Zhang, Lingdi Zhao, Wei Li, Yonghao Yang, Xiaojie Zhang, Tiejun Yang, Changfu Nie, Feng Han, Ying Liu, Suxia Luo, Quanli Gao, Yongping Song   +15 more
doaj   +1 more source

Kinetics and cellular site of glycolipid loading control [PDF]

, 2009
CD1d-restricted natural killer T cells (NKT cells) possess a wide range of effector and regulatory activities that are related to their ability to secrete both T helper 1 (Th1) cell- and Th2 cell-type cytokines.
Arora, Pooja, Baena, Andres, Baine, Ian, Bricard, Gabriel, Goldberg, Michael F., Im, Jin S., Jerud, Elliot S., Molano, Alberto, Ndonye, Rachel M., Venkataswamy, Manjunatha M., Yu, Karl O.A.   +10 more
core