Results 61 to 70 of about 125,935 (288)

Short communication: NKG2C+ NK cells contribute to increases in CD16+CD56- cells in HIV type 1+ individuals with high plasma viral load. [PDF]

, 2013
Chronic HIV-1 infection results in the expansion of both NKG2C+ and CD16+CD56- human natural killer cells. NKG2C+ cells proliferate in response to human cytomegalovirus (HCMV) and expansion of the dysfunctional CD56-CD16+ natural killer (NK) cells is ...
Gregson, John NS, Gazzard, Brian G, Goodier, Martin R, Kuri-Cervantes, Leticia, Mela, Christopher M, Bower, Mark   +5 more
core   +1 more source

Cytokine-Induced Killer Cells Eradicate Bone and Soft-Tissue Sarcomas [PDF]

Cancer Research, 2014
AbstractUnresectable metastatic bone sarcoma and soft-tissue sarcomas (STS) are incurable due to the inability to eradicate chemoresistant cancer stem–like cells (sCSC) that are likely responsible for relapses and drug resistance. In this study, we investigated the preclinical activity of patient-derived cytokine-induced killer (CIK) cells against ...
Sangiolo, Dario, Mesiano, Giulia, Gammaitoni, Loretta, Leuci, Valeria, Todorovic, Maja, Giraudo, Lidia, Cammarata, Cristina, Dell'Aglio, Carmine, D'Ambrosio, Lorenzo, Pisacane, Alberto, Sarotto, Ivana, Miano, Sara, Ferrero, Ivana, Carnevale-Schianca, Fabrizio, Pignochino, Ymera, Sassi, Francesco, Bertotti, Andrea, Piacibello, Wanda, Fagioli, Franca, Aglietta, Massimo, Grignani, Giovanni   +20 more
openaire   +3 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Researche Advances on CIK Cells and Their Clinical Use in Lung Cancer

Chinese Journal of Lung Cancer, 2011
As the leading cause of cancer-related death among human beings, lung cancer seriously threats peoples’ health all over the world. Cytokine-induced killer cells (CIK) is a new kind of adaptive immune cells characterized by its dramatic proliferation ...
Hu LUO, Xiangdong ZHOU
doaj   +1 more source

Killing of Kaposi's sarcoma-associated herpesvirus-infected fibroblasts during latent infection by activated natural killer cells. [PDF]

, 2011
Kaposi's sarcoma-associated herpesvirus (KSHV) establishes life-long infection by evading clearance by the host immune system. In de novo infection and lytic replication, KSHV escapes cytotoxic T cells and NK cells through downregulation of MHC class-I ...
Nick C. Matthews, Gotch, FM, Frances M. Gotch, Robey, Rebecca C, Bower, Mark, Rebecca C. Robey, Mark Bower, Matthews, Nick C, Goodier, Martin R, Bower, M, Goodier, MR, Robey, RC, Gotch, Frances M, Martin R. Goodier, Matthews, NC   +14 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

The activating receptors 2B4 and NTB-A, but not CRACC are subject to ligand-induced down-regulation on human natural killer cells

, 2010
Activation of natural killer cells can be mediated by different receptors. Stimulation of the receptors 2B4, NTB-A and CRACC, members of the SLAM-related receptor family, induces cytotoxicity and cytokine production.
Stephan Meinke, Carsten Watzl, Carolin Böhm, Sibel Durlanik, Carolin Böhm   +4 more
core   +2 more sources

Non-classic properties of human cytolytic lymphocytes. basic and clinical aspects [PDF]

, 2008
The immune system comprises a complex network of specialized cells and organs that function together to recognize and remove potentially harmful "non-self", i.e. pathogens, malignant cells and –by extension– also transplanted allogeneic cells.
Zenhäusern, Gabriela
core   +1 more source

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

Effect of nutrient deficiencies on in vitro Th1 and Th2 cytokine response of peripheral blood mononuclear cells to Plasmodium falciparum infection. [PDF]

, 2010
BACKGROUND: An appropriate balance between pro-inflammatory and anti-inflammatory cytokines that mediate innate and adaptive immune responses is required for effective protection against human malaria and to avoid immunopathology.
Veenemans, J., Chilongola, Jaffu O, Veenemans, Jacobien, Meijerink, M., Mbugi Erasto V, Huub FJ Savelkoul, Shao John F, Meijerink Marjolein, Savelkoul, H.F.J., Savelkoul, Huub FJ, Hans Verhoef, Matthew McCall, Jaffu O Chilongola, Olomi, Raimos M, McCall Matthew, Raimos M Olomi, Veenemans Jacobien, Shao, J.F., Mbugi, Erasto V, McCall, Matthew, Jeurink, P.V., McCall, M., Verhoef, H., Marjolein Meijerink, Verhoef Hans, Savelkoul, H.F., Chilongola Jaffu O, Erasto V Mbugi, Savelkoul Huub FJ, Chilongola, J.O., John F Shao, Jeurink, Prescilla V, Shao, John F, Olomi, R.M., Jeurink Prescilla V, Mbugi, E.V., Jacobien Veenemans, Verhoef, Hans, Chilongola, J., Meijerink, Marjolein, Olomi Raimos M, Prescilla V Jeurink   +41 more
core   +1 more source