Results 21 to 30 of about 115,050 (245)

Cytokine-induced memory-like natural killer cells [PDF]

Proceedings of the National Academy of Sciences, 2009
The mammalian immune response to infection is mediated by 2 broad arms, the innate and adaptive immune systems. Innate immune cells are a first-line defense against pathogens and are thought to respond consistently to infection, regardless of previous exposure, i.e., they do not exhibit memory of prior activation.
Megan A, Cooper, Julie M, Elliott, Peter A, Keyel, Liping, Yang, Javier A, Carrero, Wayne M, Yokoyama   +5 more
openaire   +2 more sources

A dynamic transcriptomic atlas of cytokine-induced killer cells. [PDF]

J Biol Chem, 2018
Several clinical immunotherapy trials with cytokine-induced killer (CIK) cells have been reported. However, molecular evidence of cell expansion, acquisition of tumor cytotoxicity, and safety of CIK cells is required before putting them to clinical use.
Meng M, Li L, Li R, Wang W, Chen Y, Xie Y, Han R, Zhu K, Huang W, Yang L, Li S, Shi J, Tan W, Gao H, Zhao Y, Yang L, Tan J, Hou Z.   +17 more
europepmc   +4 more sources

Efficient lysis of rhabdomyosarcoma cells by cytokine-induced killer cells: implications for adoptive immunotherapy after allogeneic stem cell transplantation

Haematologica, 2010
Background Rhabdomyosarcoma is the most common soft tissue sarcoma in childhood and has a poor prognosis. Here we assessed the capability of ex vivo expanded cytokine-induced killer cells to lyse both alveolar and embryonic rhabdomyosarcoma cell lines ...
Selim Kuçi, Eva Rettinger, Bernhard Voß, Gerrit Weber, Miriam Stais, Hermann Kreyenberg, Andre Willasch, Zyrafete Kuçi, Ewa Koscielniak, Stephan Klöss, Dorothee von Laer, Thomas Klingebiel, Peter Bader   +12 more
doaj   +1 more source

Cytokine-induced killer cells for cell therapy of acute myeloid leukemia: improvement of their immune activity by expression of CD33-specific chimeric receptors

Haematologica, 2010
Background Cytokine-induced killer cells are ex vivo-expanded cells with potent antitumor activity. The infusion of cytokine-induced killer cells in patients with acute myeloid leukemia relapsing after allogeneic hematopoietic stem cell transplant is ...
Virna Marin, Irene Pizzitola, Valentina Agostoni, Greta Maria Paola Giordano Attianese, Helene Finney, Alastair Lawson, Martin Pule, Raphael Rousseau, Andrea Biondi, Ettore Biagi   +9 more
doaj   +1 more source

MicroRNA profiling of CD3+CD56+ cytokine-induced killer cells [PDF]

Scientific Reports, 2015
AbstractStudies have proven that IL-2 and IL-15 showed contrasting roles during CIK cells preparation. By employing microarray, we analyzed miRNA expression profiles of PBMC, CIKIL-2 and CIKIL-15. Advanced bioinformatic analyses were performed to explore the key miRNAs which may regulate cell proliferation and anti-tumor activity of CIK.
Wenju Wang, Ruhong Li, Mingyao Meng, Chuanyu Wei, Yanhua Xie, Yayong Zhang, Lihong Jiang, Ruiyi Dong, Chunhui Wang, Yiming Zhong, Fang Yang, Weiwei Tang, Xingfang Jin, Baohua Liu, Zongliu Hou   +14 more
openaire   +2 more sources

Cytokine Induced Killer (CIK) Cells Based Adoptive Immunotherapy

Journal of Gandaki Medical College, 2018
Cytokine induced killer (CIK) cells has been increasingly used in adoptive immunotherapy against various cancers and viral infections. This review summarizes the basic overview of CIK cells as a therapeutic immunocyte.
S Timalsena, P P Lamichhane
doaj   +1 more source

Cytokine-induced memory-like natural killer cells for cancer immunotherapy

Stem Cell Research & Therapy, 2021
Natural killer cells are an important part of the innate immune system mediating robust responses to virus-infected and malignant cells without needing prior antigen priming.
Mubin Tarannum, Rizwan Romee
doaj   +1 more source

Killers at the crossroads: The use of innate immune cells in adoptive cellular therapy of cancer

Stem Cells Translational Medicine, 2020
Adoptive cell therapy (ACT) is an approach to cancer treatment that involves the use of antitumor immune cells to target residual disease in patients after completion of chemo/radiotherapy.
May Sabry, Mark W. Lowdell
doaj   +1 more source

Cell-based Immunotherapy for Colorectal Cancer with Cytokine-induced Killer Cells [PDF]

Immune Network, 2016
Colorectal cancer is the third leading cancer worldwide. Although incidence and mortality of colorectal cancer are gradually decreasing in the US, patients with metastatic colorectal cancer have poor prognosis with an estimated 5-year survival rate of less than 10%.
Kim, Ji Sung, Kim, Yong Guk, Park, Eun Jae, Kim, Boyeong, Lee, Hong Kyung, Hong, Jin Tae, Kim, Youngsoo, Han, Sang-Bae   +7 more
openaire   +2 more sources

CD4+ T cells are required to improve the efficacy of CIK therapy in non-small cell lung cancer

Cell Death and Disease, 2022
Herein, Liu and colleagues show that CD4+ T cells in cytokine-induced killer (CIK) cells are required to enhance the clinical efficacy of CIK therapy. In addition, CD4+ T cells help via IL-17A production is critical to restoring the function of CD8+/CD3 ...
Shaochuan Liu, Yuan Meng, Liang Liu, Yingge Lv, Wenwen Yu, Ting Liu, Limei Wang, Di Mu, Qiuru Zhou, Min Liu, Yulin Ren, Dong Zhang, Baihui Li, Qian Sun, Xiubao Ren   +14 more
doaj   +1 more source