Results 121 to 130 of about 2,261,376 (387)

Pathogenic mechanisms in the rheumatoid nodule: Comparison of proinflammatory cytokine production and cell adhesion molecule expression in rheumatoid nodules and synovial membranes from the same patient [PDF]

, 1998
R. Wikaningrum, John Highton, Angela Parker, Mark Coleman, Paul A. Hessian, P J Roberts-Thomson, Michael Ahern, Malcolm Smith   +7 more
openalex   +1 more source

Adipose mitochondrial metabolism controls body growth by modulating systemic cytokine and insulin signaling [PDF]

, 2022
Shrivani Sriskanthadevan-Pirahas, Michael J. Turingan, Joel S. Chahal, Erin Thorson, Shahoon Khan, Abdul Qadeer Tinwala, Savraj Grewal   +6 more
openalex   +1 more source

COVID-19: consider cytokine storm syndromes and immunosuppression

The Lancet, 2020
Puja Mehta, Daniel F McAuley, Michael Brown, Emilie Sanchez, R. S. Tattersall, Jessica J. Manson   +5 more
semanticscholar   +1 more source

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

An inflammatory cytokine signature predicts COVID-19 severity and survival

Nature Medicine, 2020
D. D. Del Valle, S. Kim-Schulze, Hsin-Hui Huang, N. Beckmann, Sharon Nirenberg, Bo Wang, Yonit Lavin, Talia H. Swartz, D. Madduri, A. Stock, T. Marron, Hui Xie, Manishkumar Patel, K. Tuballes, O. Van Oekelen, Adeeb H. Rahman, P. Kovatch, J. Aberg, E. Schadt, S. Jagannath, M. Mazumdar, A. Charney, A. Firpo-Betancourt, D. R. Mendu, J. Jhang, D. Reich, K. Sigel, C. Cordon-Cardo, M. Feldmann, S. Parekh, M. Merad, S. Gnjatic   +31 more
semanticscholar   +1 more source

The molecular details of cytokine signaling via the JAK/STAT pathway

Protein Science, 2018
More than 50 cytokines signal via the JAK/STAT pathway to orchestrate hematopoiesis, induce inflammation and control the immune response. Cytokines are secreted glycoproteins that act as intercellular messengers, inducing proliferation, differentiation ...
Rhiannon Morris, N. Kershaw, J. Babon
semanticscholar   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

The pathogenesis and treatment of the `Cytokine Storm' in COVID-19

Journal of Infection, 2020
Q. Ye, Bili Wang, Jian-hua Mao
semanticscholar   +1 more source

Two types of mouse T helper cell. IV. Th2 clones secrete a factor that inhibits cytokine production by Th1 clones

Journal of Experimental Medicine, 1989
A cytokine synthesis inhibitory factor (CSIF) is secreted by Th2 clones in response to Con A or antigen stimulation, but is absent in supernatants from Con A-induced Th1 clones.
D. Fiorentino, M. Bond, T. Mosmann
semanticscholar   +1 more source