Results 21 to 30 of about 2,261,376 (387)

The signal pathways and treatment of cytokine storm in COVID-19

Signal Transduction and Targeted Therapy, 2021
The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis and is more devastating than any other previous infectious disease. It has affected a significant proportion of the global population both physically and mentally, and destroyed ...
Lan Yang, Xueru Xie, Zikun Tu, Jinrong Fu, Damo Xu, Yufeng Zhou   +5 more
semanticscholar   +1 more source

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

Scientific Reports, 2017
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand ...
Ioanna Petta, Nadia Bougarne, Jolien Vandewalle, Lien Dejager, Sofie Vandevyver, Marlies Ballegeer, Sofie Desmet, Jonathan Thommis, Lode De Cauwer, Sam Lievens, Claude Libert, Jan Tavernier, Karolien De Bosscher   +12 more
doaj   +1 more source

Biological and technical variables affecting immunoassay recovery of cytokines from human serum and simulated vaginal fluid: A multicenter study [PDF]

, 2008
The increase of proinflammatory cytokines in vaginal secretions may serve as a surrogate marker of unwanted inflammatory reaction to microbicide products topically applied for the prevention of sexually transmitted diseases, including HIV-1. Interleukin (
Alfano, M, Belec, L, Carbonneil, C, Chen, S, Cosentino, L, Cummins, JE, Curtis, K, Dezzutti, CS, Donaghay, M, Doncel, GF, Donoval, B, Fichorova, RN, Grivel, JC, Guzman, E, Hayes, M, Herold, B, Hillier, S, Lackman-Smith, C, Landay, A, Margolis, L, Mayer, KH, Pallansch-Cokonis, M, Pasicznyk, JM, Poli, G, Reichelderfer, P, Richardson-Harman, N, Roberts, P, Rodriguez, I, Saidi, H, Sassi, RR, Shattock, R   +30 more
core   +2 more sources

Salivary cytokine panel indicative of non-small cell lung cancer. [PDF]

, 2018
Objective To develop a combinatorial panel of salivary cytokines that manifests the presence of non-small cell lung cancer (NSCLC) that will eventually improve prognosis by facilitating the early diagnosis and management of this common cancer. Methods We
Koizumi, Tomonobu, Shetty, Vivek, Yamaguchi, Masaki   +2 more
core   +3 more sources

COVID-19 spike polypeptide vaccine reduces the pathogenesis and viral infection in a mouse model of SARS-CoV-2

Frontiers in Immunology, 2023
The SARS-CoV-2 coronavirus, which causes a respiratory disease called COVID-19, has been declared a pandemic by the World Health Organization (WHO) and is still ongoing. Vaccination is the most important strategy to end the pandemic.
Yasmin Hisham, Sun-Min Seo, Sinae Kim, Sinae Kim, Saerok Shim, Jihyeong Hwang, Eun-Seon Yoo, Na-Won Kim, Chang-Seon Song, Hyunjhung Jhun, Ho-Young Park, Youngmin Lee, Kyeong-Cheol Shin, Sun-Young Han, Je Kyung Seong, Je Kyung Seong, Yang-Kyu Choi, Soohyun Kim, Soohyun Kim   +18 more
doaj   +1 more source

Ex vivo innate immune cytokine signature of enhanced risk of relapsing brucellosis. [PDF]

, 2013
BackgroundBrucellosis, a zoonotic infection caused by one of the Gram-negative intracellular bacteria of the Brucella genus, is an ongoing public health problem in Perú.
Feldman, Kristyn E, Gilman, Robert H, Gotuzzo, Eduardo, Hoffmann, Alexander, Loriaux, Paul M, Saito, Mayuko, Siva, Tenaya, Tuero, Iskra, Villaverde, Homarh, Vinetz, Joseph M   +9 more
core   +3 more sources

Immunopathogenesis and treatment of cytokine storm in COVID-19

Theranostics, 2021
Severe coronavirus disease 2019 (COVID-19) is characterized by systemic hyper-inflammation, acute respiratory distress syndrome, and multiple organ failure.
Jae Seok Kim, Jun Young Lee, Jae-Won Yang, Keumwha Lee, M. Effenberger, W. Szpirt, A. Kronbichler, J. Shin   +7 more
semanticscholar   +1 more source

Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

Molecular Medicine, 2013
α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3.
Siyoung Lee, Youngmin Lee, Kwangwon Hong, Jaewoo Hong, Suyoung Bae, Jida Choi, Hyunjhung Jhun, Areum Kwak, Eunsom Kim, Seunghyun Jo, Charles A. Dinarello, Soohyun Kim   +11 more
doaj   +1 more source

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

Cell Stress, 2020
Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments.
Alejandra Gomez-Cadena, Alfonso Barreto, Susana Fiorentino, Camilla Jandus   +3 more
doaj   +1 more source

The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

Haematologica, 2022
Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna, Rebecca L. King, Dragan Jevremovic, David C. Fajgenbaum, Angela Dispenzieri   +4 more
doaj   +1 more source