Results 21 to 30 of about 1,542,731 (346)

Engineering cytokines and cytokine circuits

open access: yesScience, 2020
Learning to speak the secret language of immune cells could improve ...
Wendell A. Lim, Aileen W. Li
openaire   +4 more sources

Glucocorticoid Receptor-mediated transactivation is hampered by Striatin-3, a novel interaction partner of the receptor

open access: yesScientific Reports, 2017
The transcriptional activity of the glucocorticoid receptor (GR) is co-determined by its ability to recruit a vast and varying number of cofactors. We here identify Striatin-3 (STRN3) as a novel interaction partner of GR that interferes with GR’s ligand ...
Ioanna Petta   +12 more
doaj   +1 more source

The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease

open access: yesHaematologica, 2022
Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna   +4 more
doaj   +1 more source

Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

open access: yesBiochemical Journal, 2003
The IL (interleukin)-6-type cytokines IL-6, IL-11, LIF (leukaemia inhibitory factor), OSM (oncostatin M), ciliary neurotrophic factor, cardiotrophin-1 and cardiotrophin-like cytokine are an important family of mediators involved in the regulation of the ...
P. Heinrich   +5 more
semanticscholar   +1 more source

Immune system activation by natural products and complex fractions: a network pharmacology approach in cancer treatment

open access: yesCell Stress, 2020
Natural products and traditional herbal medicine are an important source of alternative bioactive compounds but very few plant-based preparations have been scientifically evaluated and validated for their potential as medical treatments.
Alejandra Gomez-Cadena   +3 more
doaj   +1 more source

Effect of Recombinant α1-Antitrypsin Fc-Fused (AAT-Fc) Protein on the Inhibition of Inflammatory Cytokine Production and Streptozotocin-Induced Diabetes

open access: yesMolecular Medicine, 2013
α1-Antitrypsin (AAT) is a member of the serine proteinase inhibitor family that impedes the enzymatic activity of serine proteinases, including human neutrophil elastase, cathepsin G and neutrophil proteinase 3.
Siyoung Lee   +11 more
doaj   +1 more source

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

open access: yesMolecules, 2014
Curcumin (diferuloylmethane), a golden pigment from turmeric, has been linked with antioxidant, anti-inflammatory, anticancer, antiviral, antibacterial, and antidiabetic properties. Most of the these activities have been assigned to methoxy, hydroxyl, α,
Bharat B. Aggarwal   +2 more
doaj   +1 more source

Environmental and microbial factors influence affective and cognitive behavior in C57BL/6 sub-strains

open access: yesFrontiers in Immunology, 2023
C57BL/6 mice are one of the most widely used inbred strains in biomedical research. Early separation of the breeding colony has led to the development of several sub-strains.
Nada Abdel Aziz   +10 more
doaj   +1 more source

Cytokine Modulation of Keratinocyte Cytokines

open access: yesJournal of Investigative Dermatology, 1990
There is increasing evidence that epidermal cytokines may have an important role in mediating inflammatory and immune responses in the skin. A number of cell types in the epidermis are capable of secreting cytokines including keratinocytes, Langerhans cells, melanocytic cells, and even Merkle cells.
Stephen H. Hefeneider   +7 more
openaire   +3 more sources

Cytokine Storm in COVID-19: The Current Evidence and Treatment Strategies

open access: yesFrontiers in Immunology, 2020
Severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) is the pathogen that causes coronavirus disease 2019 (COVID-19). As of 25 May 2020, the outbreak of COVID-19 has caused 347,192 deaths around the world.
Yujun Tang   +5 more
semanticscholar   +1 more source

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