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The cytokine storm and COVID‐19
Journal of Medical Virology, 2020 Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in December 2019, has caused a large global pandemic and poses a serious threat to public health.
B. Hu, Shaoying Huang, L. Yin
semanticscholar +1 more source
Engineering cytokine therapeutics
Nature Reviews Bioengineering, 2023 Cytokines have pivotal roles in immunity, making them attractive as therapeutics for a variety of immune-related disorders. However, the widespread clinical use of cytokines has been limited by their short blood half-lives and severe side effects caused ...
Jeroen Deckers +15 more
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A Paradoxical Effect of Interleukin-32 Isoforms on Cancer
Frontiers in Immunology, 2022 IL-32 plays a contradictory role such as tumor proliferation or suppressor in cancer development depending on the cancer type. In most cancers, it was found that the high expression of IL-32 was associated with more proliferative and progression of ...
Saerok Shim +17 more
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The COVID-19 Cytokine Storm; What We Know So Far
Frontiers in Immunology, 2020 COVID-19 is a rapidly spreading global threat that has been declared as a pandemic by the WHO. COVID-19 is transmitted via droplets or direct contact and infects the respiratory tract resulting in pneumonia in most of the cases and acute respiratory ...
D. Ragab +4 more
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Cytokine Storm in COVID-19: Immunopathogenesis and Therapy
Medicina, 2022 A cytokine storm is a hyperinflammatory state secondary to the excessive production of cytokines by a deregulated immune system. It manifests clinically as an influenza-like syndrome, which can be complicated by multi-organ failure and coagulopathy ...
C. Zanza +9 more
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Paracrine IL-2 Is Required for Optimal Type 2 Effector Cytokine Production [PDF]
, 2017 IL-2 is a pleiotropic cytokine that promotes the differentiation of Th cell subsets, including Th1, Th2, and Th9 cells, but it impairs the development of Th17 and T follicular helper cells.
Cherukur, Yesesri +8 more
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EMBO Molecular Medicine, 2020 Systemic toxicities have severely limited the clinical application of tumor necrosis factor (TNF) as an anticancer agent. Activity‐on‐Target cytokines (AcTakines) are a novel class of immunocytokines with improved therapeutic index.
Leander Huyghe +16 more
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Global landscape of mouse and human cytokine transcriptional regulation [PDF]
, 2018 Cytokines are cell-to-cell signaling proteins that play a central role in immune development, pathogen responses, and diseases. Cytokines are highly regulated at the transcriptional level by combinations of transcription factors (TFs) that recruit ...
Fuxman Bass, Juan Ignacio +8 more
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Cytokine gene polymorphisms in preterm infants with necrotising enterocolitis: genetic association study [PDF]
, 2016 BACKGROUND The inflammatory cytokine cascade is implicated in the pathogenesis of necrotising enterocolitis (NEC). Genetic association studies of cytokine polymorphisms may help to detect molecular mechanisms that are causally related to the disease ...
Baier, R. J. +5 more
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Seminars in Immunopathology, 2017 Human coronaviruses (hCoVs) can be divided into low pathogenic and highly pathogenic coronaviruses. The low pathogenic CoVs infect the upper respiratory tract and cause mild, cold-like respiratory illness.
Rudragouda Channappanavar, S. Perlman
semanticscholar +1 more source