Results 141 to 150 of about 11,604 (173)
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Receptor recognition by gp130 cytokines.
The EMBO journal, 2000Cytokines of the gp130 family exert their diverse biological effects by formation of stable high affinity transmembrane receptor complexes that are characterized by the presence of the shared transmembrane signalling receptor gp130. Different gp130 ligands form signalling complexes that vary in both composition and stoichiometry.
J, Bravo, J K, Heath
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A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130 [PDF]
FEBS Letters, 2001 The terminal portion of the Janus kinases (Jaks) contains a divergent FERM (our‐point‐one, zrin, adixin, oesin) homology domain comprising 19 conserved hydrophobic regions. To determine the role of this domain in governing recruitment of Jak1, but not Jak3, to the gp130 subunit of the interleukin‐6 family of cytokine receptors, the interaction of three
Catharien M U Hilkens +2 more
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Acquiring signalling specificity from the cytokine receptor gp130
Trends in Genetics, 2004Repeated use of a relatively small number of intracellular signalling molecules specifies tissue- and cell-type-specific responses to pleiotropic-acting growth factors and cytokines. Currently, gaining a better understanding of these mechanisms is a major challenge. The IL-6 family of cytokines shares a common receptor subunit called gp130.
Matthias Ernst, Brendan J Jenkins
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Activation of Stat3 by Cytokine Receptor gp130 Ventralizes Xenopus Embryos Independent of BMP-4
Developmental Biology, 1999 Stat3 is one of the main signaling components of cytokine receptors, including gp130. Here we show that activation of cytokine receptor gp130 resulted in a dramatic ventralization of Xenopus embryos and that the ventralization correlated well with Stat3 activation potential of the receptor.
Ryuichi Nishinakamura +2 more
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Structure of an Extracellular gp130 Cytokine Receptor Signaling Complex
Science, 2001The activation of gp130, a shared signal-transducing receptor for a family of cytokines, is initiated by recognition of ligand followed by oligomerization into a higher order signaling complex. Kaposi's sarcoma–associated herpesvirus encodes a functional homolog of human interleukin-6 (IL-6) that activates human gp130.
D, Chow +4 more
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Structural Organization of a Full-Length gp130/LIF-R Cytokine Receptor Transmembrane Complex [PDF]
Molecular Cell, 2008 gp130 is a shared receptor for at least nine cytokines and can signal either as a homodimer or as a heterodimer with Leukemia Inhibitory Factor Receptor (LIF-R). Here, we biophysically and structurally characterize the full-length, transmembrane form of a quaternary cytokine receptor complex consisting of gp130, LIF-R, the cytokine Ciliary Neurotrophic
Georgios Skiniotis +2 more
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FEBS Letters, 1997 © 1997 Federation of European Biochemical Societies.
Kinichi Nakashima +2 more
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The Cytokine Receptor gp130: Faithfully Promiscuous
Science Signaling, 2003Diverse cytokines can signal through receptor complexes containing the gp130 subunit. These cytokines, which include interleukin (IL)-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and CLC (cardiotrophin-like cytokine), are implicated in inflammatory and immune responses ...
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Development, 1998
ABSTRACT Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. The differentiation of cholinergic sympathetic neurons is characterized by the expression of choline acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP), induced in vitro by a subfamily of cytokines, including LIF, CNTF, GPA, OSM and ...
M, Geissen +4 more
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ABSTRACT Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. The differentiation of cholinergic sympathetic neurons is characterized by the expression of choline acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP), induced in vitro by a subfamily of cytokines, including LIF, CNTF, GPA, OSM and ...
M, Geissen +4 more
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Nature Structural and Molecular Biology, 2005
gp130 is a shared cytokine signaling receptor and the founding member of the 'tall' class of cytokine receptors. A crystal structure of the ligand-binding domains of gp130 in complex with human interleukin-6 (IL-6) and its a-receptor (IL-6Ralpha) revealed a hexameric architecture in which the gp130 membrane-distal regions were approximately 100 A apart,
Georgios Skiniotis +2 more
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gp130 is a shared cytokine signaling receptor and the founding member of the 'tall' class of cytokine receptors. A crystal structure of the ligand-binding domains of gp130 in complex with human interleukin-6 (IL-6) and its a-receptor (IL-6Ralpha) revealed a hexameric architecture in which the gp130 membrane-distal regions were approximately 100 A apart,
Georgios Skiniotis +2 more
exaly +3 more sources