Results 151 to 160 of about 11,604 (173)
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Differential expression and effects of gp130 cytokines and receptors in prostate cancer cells
The International Journal of Biochemistry & Cell Biology, 2004High levels of circulating interleukin-6 (IL6), and possibly neuroendocrine (NE) differentiation, correlate with advanced prostate cancer (PCa). IL6 has many overlapping biological effects with the related gp130 cytokines LIF and OSM that can be explained by the shared usage of the signalling receptor, gp130. We set out to determine whether LIF and OSM
J, Palmer, P J, Hertzog, A, Hammacher
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gp130-Related Cytokines and Their Receptors in the Pituitary
Trends in Endocrinology and Metabolism, 1997gp130-Related cytokines such as interleukin-6 and leukemia-inhibitory factor (LIF) act on the adenohypophysis in a paracrine manner, affecting both its differentiation and the function of specific cell types, notably the proopiomelanocortin (POMC) cells. They act on POMC cells in synergism with corticotrophin-releasing hormone, inducing ACTH secretion.
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American Journal of Physiology-Heart and Circulatory Physiology, 2022
Although cardiomyocytes undergo proliferation in the early postnatal period, the regulatory mechanisms and physiological importance of this process have not been clarified. We found that the pharmacological and genetic depletion of gp130 or the neutralization of IL-6 with an antibody in preweaning mice resulted in significant impairment of ...
Hiroyuki Kawagishi +6 more
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Although cardiomyocytes undergo proliferation in the early postnatal period, the regulatory mechanisms and physiological importance of this process have not been clarified. We found that the pharmacological and genetic depletion of gp130 or the neutralization of IL-6 with an antibody in preweaning mice resulted in significant impairment of ...
Hiroyuki Kawagishi +6 more
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Shared Cytokine Signaling Receptors: Structural Insights from the Gp130 System
2004The vast majority of cytokine signaling is mediated by "shared" receptors that form central signaling components of higher-order complexes incorporating ligand-specific receptors. These include the common gamma chain (gamma(c)), common beta chain (beta(c)), and gp130, as well as others.
Martin J, Boulanger +1 more
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gp130, a Shared Signal Transducing Receptor Component for Hematopoietic and Neuropoietic Cytokines
Journal of Neurochemistry, 1996Abstract: Most of the receptors for soluble factors functioning in the hematopoietic system belong to the class I cytokine receptor family. These receptors often share common signal transducing receptor components in the same family, which explains the functional redundancy of cytokines.
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Deciphering the structure and function of class I cytokine receptors: GHR and GP130
2020Cytokine receptors play a pivotal role in many cellular processes, including metabolism control, growth, neural stem cell activation, inflammatory responses, bone, and blood cell development. Cytokine receptors do not possess intrinsic kinase activity, however, they bind Janus kinases (JAKs) via a conserved intracellular proline rich Box1 motif and a ...
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STEM CELLS, 1994
Interleukin 6 (IL-6) and related cytokines, such as leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11 exhibit multiple functions and redundancy in biological activities and play important roles in the immune response, hematopoiesis, the nervous system and acute phase reactions.
T, Hirano, T, Matsuda, K, Nakajima
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Interleukin 6 (IL-6) and related cytokines, such as leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF) and IL-11 exhibit multiple functions and redundancy in biological activities and play important roles in the immune response, hematopoiesis, the nervous system and acute phase reactions.
T, Hirano, T, Matsuda, K, Nakajima
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Cytokines oncostatin M and interleukin 1 regulate the expression of the IL-6 receptor (gp80, gp130)
Cytokine, 1995The steady-state mRNA levels of the interleukin 6 receptor (IL-6R, gp80) and its signal transducing molecule, gp130, were examined in the rat hepatoma cell line, H-35, stimulated by cytokines IL-6, IL-1, oncostatin M (OSM) and/or Dexamethasone (Dex).
M, Geisterfer, C D, Richards, J, Gauldie
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Journal of Cellular Biochemistry, 1994
AbstractThe bone marrow stroma consists of a heterogeneous population of cells which participate in osteogenic, adipogenic, and hematopoietic events. The murine stromal cell line, BMS2, exhibits the adipocytic and osteoblastic phenotypes in vitro.
J M, Gimble +7 more
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AbstractThe bone marrow stroma consists of a heterogeneous population of cells which participate in osteogenic, adipogenic, and hematopoietic events. The murine stromal cell line, BMS2, exhibits the adipocytic and osteoblastic phenotypes in vitro.
J M, Gimble +7 more
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Crystal structure of a cytokine-binding region of gp130
EMBO Journal, 1998Jeronimo Bravo +2 more
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