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[Retracted] miR‑885‑5p upregulation promotes colorectal cancer cell proliferation and migration by targeting suppressor of cytokine signaling. [PDF]
Oncol LettSu M, Qin B, Liu F, Chen Y, Zhang R.
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Small-molecule probe for IBD risk variant GPR65 I231L alters cytokine signaling networks through positive allosteric modulation. [PDF]
Sci AdvNeale I +9 more
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Suppressor of cytokine signaling-3 expression and its regulation in relation to inflammation in Chronic Obstructive Pulmonary Disease. [PDF]
Front ImmunolTinè M +15 more
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Annual Review of Immunology, 2019
Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or paracrine actions, with most cytokines acting in the immune and/or hematopoietic system. They are typically pleiotropic, controlling development, cell growth, survival, and/or differentiation. Correspondingly, cytokines are clinically important, and augmenting
Jian-Xin, Lin, Warren J, Leonard
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Cytokines are secreted or otherwise released polypeptide factors that exert autocrine and/or paracrine actions, with most cytokines acting in the immune and/or hematopoietic system. They are typically pleiotropic, controlling development, cell growth, survival, and/or differentiation. Correspondingly, cytokines are clinically important, and augmenting
Jian-Xin, Lin, Warren J, Leonard
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Cytokine receptor signaling pathways
Journal of Allergy and Clinical Immunology, 2000Cytokines represent a diverse group of molecules that transmit intercellular signals. These signals may either be autocrine (where the same cell both produces the cytokine and responds to it) or paracrine (where the cytokine is made by one cell and acts on another). Both these situations can occur simultaneously.
W J, Leonard, J X, Lin
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Cytokine signalling and disease
Expert Opinion on Therapeutic Targets, 2001Cytokines mediate their response via cell surface receptors that in turn activate intracellular signalling pathways and lead to gene activation, cell proliferation and differentiation. Many recent studies have shown that cytokine and cytokine receptor pathways are frequently mutated in disease, thus shedding light on the generation of the inflammatory ...
Linda, Hibbert, James A, Johnston
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Cytokine receptor signaling mechanisms
Current Opinion in Immunology, 1995Recent studies have dramatically advanced our understanding of the post-receptor signaling machinery engaged by members of the cytokine receptor superfamily. Proximal components of this signaling machinery are members of a novel class of protein tyrosine kinases termed JAKs. A working model proposes that ligand-induced dimerization of cytokine receptor
L M, Karnitz, R T, Abraham
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Cytokines and signal transduction
Best Practice & Research Clinical Haematology, 2005Many studies have characterized the role of growth factors in multiple myeloma (MM) pathogenesis and have derived novel therapies to improve patient outcome based upon targeting cytokines and their signaling cascades both in the MM cell and in the bone-marrow (BM) microenvironment.
Teru, Hideshima +3 more
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