Results 261 to 270 of about 772,973 (298)

Negative regulation of cytokine signaling

Journal of Leukocyte Biology, 2001
AbstractCytokines use complex signaling cascades to elicit their biological effects, many of which involve phosphorylation as a mechanism of activation. Rapid and efficient attenuation of cytokine signals is crucial to maintaining regulation of these processes and to preventing toxic side effects.
C J, Greenhalgh, D J, Hilton
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Negative Regulation of Cytokine Signaling

Clinical Reviews in Allergy & Immunology, 2005
Immune and inflammatory systems are controlled by multiple cytokines, including interleukins and interferons. Many of these cytokines exert their biological functions through Janus kinases and signal transducers and activators of transcription factors. The cytokine inducible SH2 protein (CIS) and suppressors of cytokine signaling (SOCS) are members of ...
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Cytokine receptor signalling and aging

Mechanisms of Ageing and Development, 2006
With ageing the immune system is deregulated and this leads to the development of immunosenescence mainly affecting the adaptive immune response. There is much knowledge accumulated concerning various receptor functions and signalling with ageing such as TCR, FcRs, TLRs.
T, Fulop, A, Larbi, N, Douziech, I, Levesque, A, Varin, G, Herbein   +5 more
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SOCS: suppressors of cytokine signalling

The International Journal of Biochemistry & Cell Biology, 1998
Regulation of many aspects of cell behaviour occurs through the interaction of cytokines with specific cell surface receptors, resulting in the activation of cytoplasmic signal transduction pathways. Although cellular responses to cytokines are tightly controlled, few molecules have been identified which are able to switch these signals off.
R, Starr, D J, Hilton
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Janus kinases in cytokine signalling

Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1996
Hematopoiesis is largely regulated by the binding of cytokines to receptors of the cytokine receptor superfamily. Although lacking catalytic domains, members of the cytokine receptor superfamily mediate ligand dependent activation of tyrosine phosphorylation which is critical for all receptor functions.
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Signals | Cytokines

2021
Xianglan Yao, Stewart J. Levine
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Cytokine signal transduction

Cell, 1994
T, Kishimoto, T, Taga, S, Akira
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Cytokines: sources, receptors and signalling

Baillière's Clinical Gastroenterology, 1996
Cytokines are a family of protein mediators that are important in transducing information between various cell types. These messengers are synthesized by a broad spectrum of cells. Cellular sources of cytokines include those cell types considered to play pivotal roles in the immune system as well as in inflammatory responses, including lymphocytes ...
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Cytokine signal transduction.

Receptor, 1995
The normal growth, maturation, and activation of cells in most tissues requires stimulation with a defined set of growth factors. These growth factors bind cognate receptors on surface of target cells, and stimulate specific intracellular signals. Many of these signals culminate in the induction of a ligand-specific set of genes.
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Systematic investigation of cytokine signaling activity at the tissue and single-cell levels

Nature Methods, 2021
Peng Jiang, Beibei Ru, Grégoire Altan-Bonnet   +2 more
exaly