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Nature, 1995
Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Many cell functions are regulated by members of the cytokine receptor superfamily. Signalling by these receptors depends upon their association with Janus kinases (JAKs), which couple ligand binding to tyrosine phosphorylation of signalling proteins recruited to the receptor complex.
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Signal TransductionThrough Cytokine Receptors
International Reviews of Immunology, 1998Receptors for interleukins, colony stimulating factors, and hormones have a homology in their extracellular regions, characterized by the conserved cysteine residues and the tryptophan-serine-x-tryptophan-serine motif, thus, they are classified to the type 1 cytokine receptor superfamily.
M, Hibi, T, Hirano
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2000
Abstract The study of cytokines as a discrete topic has existed for approximately two decades. Initial studies focused on the identification of new cytokines, a process that is still continuing, with approximately 150 having been identified to date.
B M J Foxwell +3 more
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Abstract The study of cytokines as a discrete topic has existed for approximately two decades. Initial studies focused on the identification of new cytokines, a process that is still continuing, with approximately 150 having been identified to date.
B M J Foxwell +3 more
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Cytokine receptors and signal transduction
Progress in Growth Factor Research, 1994Cytokines are important regulators of hemopoiesis which exert their actions by binding to specific, high affinity, cell surface receptors. In the past several years, molecular cloning of these receptors has revealed a new superfamily referred to as the hemopoietic growth factor receptors. Members of this family are defined by a 200 amino acid conserved
A L, Mui, A, Miyajima
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Cytokine receptors and signal transduction
The FASEB Journal, 1992Most of the recently cloned cytokine receptors that operate in the immune and hematopoietic systems contain no tyrosine kinase domains in their cytoplasmic regions, unlike the family of growth factor receptors defined earlier. However, they can be assigned to several new types of receptor families based on structural similarities ...
T, Taga, T, Kishimoto
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Cytokines and signal transduction
The Clinical Investigator, 1994Cytokines are signaling molecules that coordinate cellular interactions in immune and hematopoietic systems. During the past 5 years many cytokines and their receptors have been identified and cloned. With a few exceptions, cytokine receptors do not contain any known signaling domains and therefore, in order to trigger a specific cellular response, new
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Negative Regulators of Cytokine Signaling
International Journal of Hematology, 2001The interaction of a cytokine with its specific cell surface receptor triggers the activation of intracellular signaling pathways that ultimately program the cellular response. Although the specific components and actions of the pathways driving these responses, such as the Janus kinase (JAK)/signal transducers and activators of transcription (STAT ...
B T, Kile, N A, Nicola, W S, Alexander
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Glucocorticoid modulation of cytokine signaling
Tissue Antigens, 2006Abstract Cytokine signaling is essential for intercellular communication and affects cell proliferation, differentiation, and survival. In the immune system, cytokines coordinate the activities of many cell types ultimately leading to both innate and adaptive immune responses.
I, Rogatsky, L B, Ivashkiv
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Lipid rafts in cytokine signaling
Cytokine & Growth Factor Reviews, 2004Lipid rafts are established as critical structures for a variety of cellular processes, including immune cell activation. Beyond their importance for initial immune cell activation at the immunological synapse, lipid rafts are now also being recognized as important sites for cytokine and growth factor signal transduction, both in immune cells as part ...
Rakesh, Rao +4 more
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PML control of cytokine signaling
Cytokine & Growth Factor Reviews, 2014The promyelocytic leukemia (PML) protein is a tumor suppressor acting as the organizer of nuclear matrix-associated structures named nuclear bodies (NBs). The involvement of PML in various cell processes, including cell death, senescence or antiviral defense underlines the multiple functions of PML due to its ability to interact with various partners ...
Ghizlane, Maarifi +2 more
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