Results 1 to 10 of about 71,915 (261)
A Human β-Defensin-Based Recombinant Protein DF2-HSA Ameliorates Cytokine Storm [PDF]
CellsCytokine storm is a critical driver of acute respiratory distress syndrome and multiple organ failure. Human β-defensin 2 (HBD-2) is the first inducible defensin discovered in human body.
Yibo Du +7 more
doaj +2 more sources
JACC: Case Reports, 2020 As health systems worldwide grapple with the coronavirus disease-2019 (COVID-19) pandemic, patients with durable LVAD support represent a unique population at risk for the disease.
Vinh Q. Chau, MD +9 more
doaj +2 more sources
Subduing the Inflammatory Cytokine Storm. [PDF]
Int J Mol SciThe inflammatory cytokine response is essential for protective immunity, yet bacterial and viral pathogens often elicit an exaggerated response (“cytokine storm”) harmful to the host that can cause multi-organ damage and lethality. Much has been published recently on the cytokine storm within the context of the coronavirus pandemic, yet bacterial ...
Kaempfer R.
europepmc +3 more sources
Dynamics of a cytokine storm. [PDF]
PLoS ONE, 2012 Six volunteers experienced severe inflammatory response during the Phase I clinical trial of a monoclonal antibody that was designed to stimulate a regulatory T cell response.
Hao Hong Yiu +2 more
doaj +4 more sources
Journal of Investigative Medicine High Impact Case Reports, 2016 Hemophagocytic lymphohistiocytosis (HLH) is a rare but life-threatening disease caused by excessive immune activation. Acquired HLH is seen in adults and is often caused by infection or malignancy.
Tiffany Y. Shaw MD, Michael Schivo MD
doaj +2 more sources
Annual Review of Medicine, 2023 Cytokine storm syndrome (CSS), which is frequently fatal, has garnered increased attention with the ongoing coronavirus pandemic. A variety of hyperinflammatory conditions associated with multiorgan system failure can be lumped under the CSS umbrella, including familial hemophagocytic lymphohistiocytosis (HLH) and secondary HLH associated with ...
Randy Q, Cron +2 more
openaire +2 more sources
CXCL13 is a predictive biomarker in idiopathic multicentric Castleman disease
Nature Communications, 2022 Idiopathic multicentric Castleman disease (iMCD) is a life-threatening inflammatory disease requiring immediate intervention, for which the recommended first-line therapy is the Interleukin-6 pathway inhibitor siltuximab.
Sheila K. Pierson +11 more
doaj +1 more source
The lymph node transcriptome of unicentric and idiopathic multicentric Castleman disease
Haematologica, 2022 Castleman disease is a polyclonal lymphoproliferative disorder characterized by unicentric or multicentric lymphadenopathy with characteristic histomorphological features, in addition to variable inflammatory symptomatology. The molecular mechanisms and
Pedro Horna +4 more
doaj +1 more source
Absence of “Cytokine Storm” in Hospitalized COVID-19 Patients: A Retrospective Cohort Study
Infectious Disease Reports, 2021 Background: A rapidly growing number of publications cite “cytokine storm” as a contributing factor in coronavirus disease 2019 (COVID-19) pathology. However, a few recent reports led to questioning of “cytokine storm” theory in COVID-19.
Maeghan L. Ciampa +6 more
doaj +1 more source