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The Role of Cytokines and Chemokines in Severe Acute Respiratory Syndrome Coronavirus 2 Infections
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in countless infections and caused millions of deaths since its emergence in 2019.
Ren-Jun Hsu +10 more
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Although the etiopathogenesis of infections has been largely illuminated by technical and scientific developments in the past century; many issues are still not clear today. The word 'there is no disease, there is a patient' is stil valid today.
Mustafa Kurtuluş, Ibrahim Pirim
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Cytokine Storm in the Novel Coronavirus Infection and Methods of its Correction
The aim of the study was to identify the role of cytokine storm in COVID-19, that emerged at the end of 2019, based on the analysis of 80 publications, including 17.4% Russian and 82.6% foreign publications for 2014–2020 with an average impact factor of ...
A. V. Ershov +3 more
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Cytokine storm is an acute hyperinflammatory response that may be responsible for critical illness in many conditions including viral infections, cancer, sepsis, and multi-organ failure.
Sonu Bhaskar +21 more
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Calming the cytokine storm [PDF]
Two papers show that combining IL-1 blockade with chimeric antigen receptor T cell therapy for cancer can prevent the induction of a potentially lethal ‘cytokine storm’.
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Major predictive risk factors for а cytokine storm in COVID-19 patients (a retrospective clinical trials) [PDF]
Background: According to WHO, as of March 31, 2021, 127 877 462 confirmed cases of the new COVID-19 coronavirus infection were registered in the world, including 2 796 561 deaths (WHO Coronavirus Disease).
Anna Yu. Anisenkova +12 more
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Case Report: Tocilizumab for the Treatment of SARS-CoV-2 Infection in a Patient With Aplastic Anemia
While cytokine storm develops in a minority of patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection, novel treatment approaches are desperately needed for those in whom it does.
Gina Keiffer +5 more
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It has been postulated that the underlying pathophysiology of COVID-19 is mediated by cytokine storm resulting in a hyperinflammatory state. A similar kind of cytokine-storm has been described in individuals undergoing veno-venous extracorporeal membrane
Kelsey Kaman +4 more
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U.S. and Brazilian researchers have found that SLIT2 can prevent tissue damage and death caused by the cytokine storm during bacterial sepsis or severe viral infections. Navigen Pharmaceuticals has licensed the findings and thinks the protein's enhancement of vascular stability could be more effective than strategies that target individual cytokines.
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Interferon lambdas: the next cytokine storm [PDF]
For two decades the scientific community has sought to understand why some people clear hepatitis C virus (HCV) and others do not. Recently, several large genome-wide association studies have identified single nucleotide polymorphisms (SNPs) linked to interferon lambda 3 (IFNλ3) that are associated with the spontaneous resolution and successful ...
Kelly, C, Klenerman, P, Barnes, E
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