Results 51 to 60 of about 101,216 (235)
Frontiers in Oncology, 2021 Defects in cytoskeleton functions support tumorigenesis fostering an aberrant proliferation and promoting inappropriate migratory and invasive features.
Valentina Fragliasso +5 more
doaj +1 more source
ESCRT-III mediated cell division in Sulfolobus acidocaldarius - a reconstitution perspective [PDF]
, 2014 In the framework of synthetic biology, it has become an intriguing question what would be the minimal representation of cell division machinery. Thus, it seems appropriate to compare how cell division is realized in different microorganisms. Inparticular,
Härtel, T., Schwille, P.
core +2 more sources
KDM4A Erases the H3R17me2a Mark, Facilitating Chromosome Condensation
Advanced Science, EarlyView.This study reveals a reversible histone modification switch governing chromosome condensation during mitosis. PKCα‐activated KDM4A removes H3R17me2a, permitting Suv39h1‐driven H3K9me3 deposition. This epigenetic transition recruits the chromosomal passenger complex and triggers Aurora B‐dependent H3S10 phosphorylation, coordinating chromatin remodeling
Yena Cho +6 more
wiley +1 more source
eLife, 2017 The actomyosin ring generates force to ingress the cytokinetic cleavage furrow in animal cells, yet its filament organization and the mechanism of contractility is not well understood.
Felix Spira +8 more
doaj +1 more source
Developmental Cell, 2006 Temporal and spatial coordination of cytokinesis with chromosome segregation is key for successful cell division, but it is poorly understood. A recent article in Science by Pellman and coworkers (Yoshida et. al., 2006) reveals how the yeast polo-like kinase Cdc5 triggers Rho1/RhoA activation and the assembly of the contractile actin ring during ...
Rauter, Harald, Barral, Yves
openaire +2 more sources
Logic‐Gated HSV‐TK/GCV Suicide Gene Circuit for Triple‐Negative Breast Cancer
Advanced Science, EarlyView.The BRAS comprises two modular genetic components driven by distinct tumor‐specific promoters and a failsafe layer with the NOT gate. This multi‐input logic gate circuit enables precise, specific expression of HSV‐TK in breast cancer cells with hardly expression in normal cell and effectively inhibits tumor growth in a triple‐negative breast cancer ...
Shasha Tang +10 more
wiley +1 more source
eLife, 2015 Cytokinesis requires activation of the GTPase RhoA. ECT-2, the exchange factor responsible for RhoA activation, is regulated to ensure spatiotemporal control of contractile ring assembly.
Donglei Zhang, Michael Glotzer
doaj +1 more source
Understanding Cytokinesis Failure [PDF]
, 2010 Cytokinesis is the final step in cell division. The process begins during chromosome segregation, when the ingressing cleavage furrow begins to partition the cytoplasm between the nascent daughter cells. The process is not completed until much later, however, when the final cytoplasmic bridge connecting the two daughter cells is severed. Cytokinesis is
Guillaume, Normand, Randall W, King
openaire +2 more sources
The Toxoplasma gondii active serine hydrolase 4 regulates parasite division and intravacuolar parasite architecture [PDF]
, 2018 Hydrolase are enzymes that regulate diverse biological processes, including posttranslational protein modifications. Recent work identified four active serine hydrolases (ASHs) in Toxoplasma gondii as candidate depalmitoylases. However, only TgPPT1 (ASH1)
Amara, Neri +7 more
core +2 more sources
Advanced Science, EarlyView.Hypertrophic scar formation is driven by excessive mitochondrial fission in wound macrophages, which we discover is governed by a novel AURKB‐DRP1(Ser616) axis. The study develops a targeted therapy using cRGD‐decorated extracellular vesicles to deliver the natural compound Asiaticoside specifically to macrophages.
Luyu Li +8 more
wiley +1 more source