Results 131 to 140 of about 44,623 (260)

ImmTACs overcome cytotoxic T cell suppression. [PDF]

Immunother Adv
Huynh L, Aljohani A, Alsubaiti A, Grant T, Chapman A, Phillips G, Chamberlain J, Hayward-Wills A, Jungwirth U, Salio M, Holland CJ, Wülfing C.   +11 more
europepmc   +2 more sources

F7 Drives Gastric Cancer Metastasis Through Anoikis Resistance and Tumor Microenvironment Remodeling

Advanced Science, Volume 13, Issue 61, 3 November 2026.
ABSTRACT Coagulation factor VII (F7) has been implicated in tumor progression; however, its role in gastric cancer metastasis and immune evasion remains incompletely understood. In this study, we identified F7 as a clinically relevant driver of gastric cancer.
Lei Gao, Qinying Han, Yunpeng Wang, Xuemei Li, Bofang Wang, Baohong Gu, Weidong Li, Lin Xiang, Ying Zhang, Hao Chen   +9 more
wiley   +1 more source

In Vivo Nb4C3Tx MXene‐Assisted Photothermal Therapy of Melanoma in Mice

Advanced NanoBiomed Research, Volume 6, Issue 11, November 2026.
Nb4C3Tx MXene converts pulsed 1064 nm irradiation into localized heat, producing concentration‐ and time‐dependent melanoma cell killing in vitro and suppressing tumor growth in mice. Histology reveals extensive tumor damage, macrophage‐associated material clearance, and no detectable persistent deposits in examined visceral organs, supporting Nb4C3Tx ...
Anton Roshchupkin, Benjamin Chacon, Gulnaz Gahramanova, Inna Chorna, Zhanna Klishchova, Anastasia Konieva, Ilya Yanko, Andrii Liutyi, Milena Yalyzhko, Ivan Baginskiy, Veronika Zahorodna, Júlio Sílvio de Sousa Bueno Filho, Erfan Rezvani Ghomi, Igor Panko, Tetiana Shapochka, Oksana Sulaieva, Oleksandr Solodovnyk, Lucia Gemma Delogu, Oleksiy Gogotsi, Laura Fusco, Sergiy Kyrylenko, Yury Gogotsi, Maksym Pogorielov   +22 more
wiley   +1 more source

Targeting Ninjurin‐1‐Mediated Microglial Pyroptosis Attenuates Neuroinflammation and Neuronal Injury Following Intracerebral Hemorrhage

Brain and Behavior, Volume 16, Issue 11, November 2026.
In response to intracerebral hemorrhage, NF‐κB signaling upregulates Nlrp3 and Ninjurin‐1 (Ninj1) in microglia. NLRP3 inflammasome activation triggers GSDMD pore formation, whereas Ninj1 oligomerizes to execute terminal plasma membrane rupture (PMR) and DAMP release (such as HMGB1).
Liqiang Peng, Aosheng Peng, Hui Zhu, Ting Sun, Pan Liu, Ting Qi   +5 more
wiley   +1 more source

Redirected Cytolysis [PDF]

, 2020
openaire   +1 more source

MLMP: A Methylation‐Associated lncRNA‐mRNA Prognostic Signature for Endometrial Carcinoma

Cancer Medicine, Volume 15, Issue 11, November 2026.
ABSTRACT Background Endometrial carcinoma (EC) is one of the most common gynecological malignancies. Aberrant DNA methylation (DNAm) is an important epigenetic alteration involved in cancer progression. Long non‐coding RNAs (LncRNAs) play critical roles in gene regulation and pathological processes.
Hong Kou, Mu Su, Jie Zhou, Yujie Liu, Yuan Wang, Jie Xing, Hongli Wang, Xueting Liu, Xinwen Wang, Yunyan Zhang, Sijia Liu   +10 more
wiley   +1 more source

An Immune‐Metabolic Signature Reveals Prognostic Stratification and Tumor Microenvironment Features in Breast Cancer

Cancer Medicine, Volume 15, Issue 11, November 2026.
This study developed and validated an 11‐gene immune‐metabolic riskScore that independently stratifies overall survival in breast cancer across multiple public and institutional cohorts. It further reveals distinct stromal–immune states, CAF‐related programs, and potential immunotherapy responsiveness, supporting its prognostic and translational value.
Sijia Dong, Wenxiao Xu, Shan Liu, Kun Zhang, Kaihong Deng, Zhigao Li, He Ren   +6 more
wiley   +1 more source

Induction and blocking of cytolysis in CD2+, CD3- NK and CD2+, CD3+ cytotoxic T lymphocytes via CD2 50 KD sheep erythrocyte receptor

, 1986
The 50 KD sheep red blood cell antigen receptor CD2 is the earliest T cell differentiation marker and is present on all blood-derived T cells, including natural killer (NK) cells.
Roozemond, R.C., Bolhuis, R.L.H., Griend, R.J. van de   +2 more
core  

M11‐CAR T cells inhibit murine cytomegalovirus in vitro upon recognition of virion‐ and cell‐associated glycoprotein B

Clinical &Translational Immunology, Volume 15, Issue 11, 2026.
Abstract Objectives Viral infections are predominantly managed with conventional antiviral drugs, which, despite their efficacy, can cause toxicity and promote resistance. Cell‐based immunotherapies offer an alternative, but cytomegaloviruses (CMV) profoundly interfere with MHC class I antigen presentation, thereby impairing conventional virus‐specific
Sabrina Kübel, Christopher Garçon, Hanna Menschikowski, Arne Cordsmeier, Jens‐Christian Albrecht, Friederike Oltmanns, Larissa Bauer, Manuel Hermann, Kristina Holdt, Heinrich Sticht, Marco Thomas, Thomas H Winkler, Brigitte Scholz, Doris Jungnickl, Armin Ensser   +14 more
wiley   +1 more source

Bisphenol A Induces DNA Damage and Differential Cytotoxicity in Thyroid Cells: High‐Dose Effects Challenge Regulatory Thresholds

Journal of Applied Toxicology, Volume 46, Issue 11, Page 3882-3892, November 2026.
ABSTRACT Bisphenol A (BPA), a ubiquitous environmental endocrine disruptor, has been implicated in carcinogenesis; however, its effects on thyroid cells remain unclear. This study investigated BPA‐induced cytotoxicity and genotoxicity in thyroid cell lines, including normal follicular (Nthy‐ori 3‐1), papillary carcinoma (TPC‐1 and BCPAP) and anaplastic
Izabela Fernanda Dal' Bó, Natássia Elena Bufalo, Valdemar Máximo, Laura Sterian Ward   +3 more
wiley   +1 more source