Results 151 to 160 of about 44,623 (260)

IL-15 boosts mesothelin- and CD70-CAR NK cell potency in PDAC without added benefit from dual targeting. [PDF]

Mol Ther Oncol
Gehrcken L, Ott J, Van den Eynde A, Lau HW, Liu D, Hermans C, Verhezen T, Peeters S, Faghel C, Joye P, Roex G, Campillo-Davo D, Lion E, Elvas F, Koljenovic S, De Waele J, Hartman V, Roeyen G, Prenen H, Lardon F, Deben C, Smits E, Van Audenaerde J.   +22 more
europepmc   +1 more source

Adhesion-induced eosinophil cytolysis requires the RIPK3-MLKL signaling pathway which is counter-regulated by autophagy.

, 2017
Eosinophils are a subset of granulocytes which can be involved in the pathogenesis of different diseases, including allergy. Their effector functions are closely linked to their cytotoxic granule proteins.
Simon, Hans-Uwe, Merz-Stoeckle, Christina, Hlushchuk, Ruslan, Spaeth, Peter J, de Graauw, Elisabeth, Styp-Rekowska, Beata, Yousefi, Shida, Simon, Dagmar, Radonjic-Hoesli, Susanne, Wang, Xiaoliang   +9 more
core  

Alcohol‐Associated Liver Disease: Epidemiology, Pathogenesis, and Emerging Therapeutic Targets

MedComm, Volume 7, Issue 11, November 2026.
ALD imposes a growing global burden influenced by alcohol consumption, genetic susceptibility, and obesity. Its pathogenesis involves interactions among ethanol metabolism, oxidative stress, innate immune activation, regulated cell death, and disruption of the gut–liver axis.
Shuyan Wang, Yirui Hu, Huikuan Chu
wiley   +1 more source

OTUD1 Prevents Immunosuppression via Promoting Lysosomal‐Associated Degradation of PD‐L1

MedComm, Volume 7, Issue 11, November 2026.
OTUD1 interacts with AKT and decreases AKT‐mTOR pathway activity, facilitating the translocation of TFEB to the nucleus, thereby triggering autophagy‐dependent degradation of PD‐L1 in lysosomes. . ABSTRACT Upregulation of PD‐L1 on tumor cells is a pivotal aspect of immune evasion, leading to treatment resistance, tumor recurrence, and metastasis ...
Yang Hao, Hengzong Zhou, Yanxin Liu, Minjun Jin, Qiang Feng, Tiantian Li, Qirong Li, Yahui Zhen, Tong Sun, Chenhao Li, Dongxu Wang   +10 more
wiley   +1 more source

Data-driven computational modeling of CAR-T cell function. [PDF]

Front Immunol
Shah V, Womack JA, Palen K, Johnson BD, Hematti P, Kearl TJ, Shah NN, Terhune SS, Dash RK.   +8 more
europepmc   +1 more source

Effects of Deltamethrin and Endosulfan on the Hepatic Markers and Neurobehavioural Alterations in Japanese Quail (Coturnix japonica)

Veterinary Medicine and Science, Volume 12, Issue 6, November 2026.
Japanese quail were exposed to combined low or high doses of deltamethrin and endosulfan by daily oral gavage for 3 weeks. Co‐exposure produced dose‐dependent hepatotoxicity and metabolic disruption, with elevated AST (aspartate aminotransferase), ALP (alkaline phosphatase), LDL, VLDL and cholesterol alongside reduced body and kidney weights.
Saba Malik, Shoaib Ahmad, Muhammad Naeem, Iqra Bibi, Muhammad Sakandar Majid, Hafiza Sadia, Sheeba Riaz, Md Abu Bakkar Siddik   +7 more
wiley   +1 more source

The Paediatric BCG Vaccine Century: From Historical Success to Future Innovations

Acta Paediatrica, Volume 115, Issue 11, Page 2433-2440, November 2026.
ABSTRACT Aim The tuberculosis (TB) vaccine, Bacille‐Calmette‐Guérin (BCG), protects infants against severe forms of primary TB. Yet, it does not protect against pulmonary reactivation TB in adults. Methods A literature review was conducted between 1st January and 28th February 2025 using PubMed, Google Scholar and reports of the World Health ...
Stefan H. E. Kaufmann
wiley   +1 more source

Eosinophil biology in COPD: from scientific insight to clinical treatment action. [PDF]

ERJ Open Res
Cass SP, Bafadhel M.
europepmc   +1 more source

Interleukin‐12: Central Roles in Immune Regulation and Disease Therapy

Immunology &Cell Biology, Volume 104, Issue 10, Page 996-1014, November‐December 2026.
IL‐12 levels are tightly regulated to balance effective protective immunity against infections and cancer with the risk of excessive inflammation and autoimmune disease. Both insufficient and excessive IL‐12 activity can therefore be detrimental, highlighting the importance of precisely controlling its production and signaling. ABSTRACT Interleukin‐12 (
Anthi Psoma, Geert van den Bogaart
wiley   +1 more source

Rapid assessment of immune effector cell-mediated cytotoxicity using mRNA lipid nanoparticles. [PDF]

Front Immunol
Mollica P, Li J, Kim SH, Goncalves B, Chen Y, Bharti A, O'Neill D, Weber E, Alameh M, Ma L.   +9 more
europepmc   +1 more source