Results 161 to 170 of about 44,623 (260)

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, Volume 179, Issue 3, Page 418-433, November 2026.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

Galectin-10 and Charcot-Leyden Crystals in Chronic Rhinosinusitis with Nasal Polyps: Pathogenetic Insights and Clinical Implications. [PDF]

Diagnostics (Basel)
Kamiński B, Ochab D, Kopczyński J, Łacwik P, Pałczyński C.   +4 more
europepmc   +1 more source

A MUC13 Variant Enhances Intestinal Ferric Iron Absorption in Unexplained Hyperferritinemia

Liver International, Volume 46, Issue 11, November 2026.
ABSTRACT Background & Aims Hyperferritinemia frequently remains unexplained despite comprehensive evaluation. We conducted a sequencing‐based exome association study to identify genetic variants associated with plasma ferritin levels in patients with unexplained hyperferritinemia.
Jonas Callet, Yong H. Sheng, Yaowu He, Maël Silva Rodriguez, Céline Chéry, Ramia Safar, Françoise Barbé, Mouni Bensenane, Rosa‐Maria Guéant‐Rodriguez, Fares Namour, Guillaume Gauchotte, Janelle Louise Hancock, Hana Manceau, Thibaud Lefebvre, Dimitri Tchernitchko, Hervé Puy, Timothy H. Florin, Jakob Begun, John D. Hooper, Jean‐Pierre Bronowicki, Michael A. McGuckin, Jean‐Louis Guéant, Abderrahim Oussalah   +22 more
wiley   +1 more source

CAR19 Tregs treat murine chronic graft-versus-host disease through immune suppression without measurable B cell cytolysis. [PDF]

JCI Insight
Jin S, Zaiken MC, McDonald-Hyman C, Hartigan CR, Bolivar-Wagers S, Larson JH, Peng Y, Hani S, Riddle M, Saha A, Panoskaltsis-Mortari A, Ko E, Zhao Y, Amaro Marquez R, Marri Baskar PS, Eide CR, Murphy WJ, Hippen KL, Hill GR, Tolar J, Sage PT, Pennell CA, Kean LS, Blazar BR.   +23 more
europepmc   +1 more source

Circulating Natural Killer Cells in Patients With Type 2 Diabetes and Peripheral Neuropathy Are Altered in Their Frequency and Exhibit Impaired Functions and Angiogenic Activities

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Neuropathic T2DM is characterized by increased circulating NK‐cell frequency but impaired NK‐cell function. Functional defects, including reduced degranulation and diminished pro‐angiogenic activity, together with an inflammatory cytokine milieu, promote macrophage recruitment, vascular inflammation, and defective angiogenesis, highlighting NK‐cell ...
Maria Teresa Palano, Federica Riccio, Luisa Sambado, Elena Tagliabue, Milena Bertolotti, Marzia Campanile, Martina Mutoli, Fiorenza Lotti, Andrea Rampin, Cristian Rubuano, Giorgia Maspero, Antonio Antico, Francesca Pitzalis, Matteo Fassan, Piero Maria Stefani, Paola Ostano, Giovanna Chiorino, Nicolò Baranzini, Laura Pulze, Annalisa Grimaldi, Antonino Bruno, Maria Sambataro, Gaia Spinetti   +22 more
wiley   +1 more source

PTPN1/PTPN2 inhibition improves NK cancer therapy by enhancing IL-2 and mitigating TGFβ1 responses. [PDF]

EMBO Rep
Feng CH, Peltier L, Chouleur T, DiPonzio M, Aubry I, Poirier AJ, Cordova ZM, Shen Y, Tabariès S, Cao X, Chen G, Bikfalvi A, Vidal SM, Siegel PM, Laneuville P, Tremblay ML.   +15 more
europepmc   +1 more source

Lugol's Iodine as a Key Treatment in Transient Gestational Thyrotoxicosis: A Case Report. [PDF]

Case Rep Endocrinol
Mabrouk M, Bchir N, El Guiche D, Ben Chehida A, Mraihi E, Zouaoui C, Ouertani H.   +6 more
europepmc   +1 more source

J Exp Med

To investigate the role of Lyt-2 and Thy-1 in cytolysis, we have generated, by ethyl methanesulfonate mutagenesis and selection, variants of the cloned cytolytic T lymphocyte line L3 that specifically lack either Lyt-2 or Thy-1.

core  

Cytolysis limits IFN-I and effector memory CD8 T cells after viral vector vaccination. [PDF]

Mol Ther Nucleic Acids
Penaloza-MacMaster P.
europepmc   +1 more source

Rehydrated Air-Dried Pap Smears as a Cost-Effective Alternative to Conventional Cytology in Low-Resource Settings: A Cytomorphological Comparative Study. [PDF]

Cureus
Hembram P, Paswan MK, Mahto SK, Hansdah P, Jamaiyar A.   +4 more
europepmc   +1 more source