Results 51 to 60 of about 306 (179)

Cannabis sativa L. and Nonpsychoactive Cannabinoids: Their Chemistry and Role against Oxidative Stress, Inflammation, and Cancer

BioMed Research International, Volume 2018, Issue 1, 2018., 2018
In the last decades, a lot of attention has been paid to the compounds present in medicinal Cannabis sativa L., such as Δ9‐tetrahydrocannabinol (Δ9‐THC) and cannabidiol (CBD), and their effects on inflammation and cancer‐related pain. The National Cancer Institute (NCI) currently recognizes medicinal C.
Federica Pellati, Vittoria Borgonetti, Virginia Brighenti, Marco Biagi, Stefania Benvenuti, Lorenzo Corsi, Claudio Tabolacci   +6 more
wiley   +1 more source

Sestrin2 as a Novel Biomarker and Therapeutic Target for Various Diseases

Oxidative Medicine and Cellular Longevity, Volume 2017, Issue 1, 2017., 2017
Sestrin2 (SESN2), a highly conserved stress‐inducible metabolic protein, is known to repress reactive oxygen species (ROS) and provide cytoprotection against various noxious stimuli including genotoxic and oxidative stress, endoplasmic reticulum (ER) stress, and hypoxia.
Mazhar Pasha, Ali H. Eid, Assaad A. Eid, Yves Gorin, Shankar Munusamy, Alexander N. Orekhov   +5 more
wiley   +1 more source

Diagnostic and Treatment Algorithms of Ulcerative Colitis in Ukraine [PDF]

, 2009
Questions concerning the diagnosis and treatment of ulcerative colitis (UC) in Ukraine are described, in recent years, there has been considerable progress in conservative therapy and new drugs have been developed that provide persistent remission of the
Skrypnyk, I., Скрипник, Ігор Миколайович   +1 more
core   +1 more source

Gastroprotective Value of Berries: Evidences from Methanolic Extracts of Morus nigra and Rubus niveus Fruits

Gastroenterology Research and Practice, Volume 2017, Issue 1, 2017., 2017
This study evaluated the gastroprotective value of the methanol extracts from fruits of Morus nigra L. (black mulberry (MEMN)) and Rubus niveus Thunb (raspberry (MERN)). The total phenolic compounds and flavonoids were measured, as well as the in vitro 2,2‐diphenyl‐1‐picrylhydrazyl (DPPH) free radical scavenger activity. The gastroprotective effects of
Luciane Angela Nottar Nesello, Maria Luisa Maes Lima Beleza, Marihá Mariot, Luísa Nathália Bolda Mariano, Priscila de Souza, Adriana Campos, Valdir Cechinel-Filho, Sérgio Faloni Andrade, Luísa Mota da Silva, Kazuhiko Uchiyama   +9 more
wiley   +1 more source

Cytoprotection as an available means in the therapy of occupational diseases (literature review) [PDF]

, 2021
In this article presents a literature review of the use of cytoprotective drugs in the treatment of occupational pathology. The possibilities and prospects of using cytoprotectors in the complex therapy of occupational diseases are considered.
Гоголева, О. И., Gavrikov, P. G., Saitov, A. S., Саитов, А. С., Гавриков, П. Г., Gogoleva, O. I.   +5 more
core  

Microbial and Natural Metabolites That Inhibit Splicing: A Powerful Alternative for Cancer Treatment

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
In eukaryotes, genes are frequently interrupted with noncoding sequences named introns. Alternative splicing is a nuclear mechanism by which these introns are removed and flanking coding regions named exons are joined together to generate a message that will be translated in the cytoplasm. This mechanism is catalyzed by a complex machinery known as the
Nancy Martínez-Montiel, Nora Hilda Rosas-Murrieta, Mónica Martínez-Montiel, Mayra Patricia Gaspariano-Cholula, Rebeca D. Martínez-Contreras, Yiannis Kourkoutas   +5 more
wiley   +1 more source

Role of Endogenous Sulfur Dioxide in Regulating Vascular Structural Remodeling in Hypertension

Oxidative Medicine and Cellular Longevity, Volume 2016, Issue 1, 2016., 2016
Sulfur dioxide (SO2), an emerging gasotransmitter, was discovered to be endogenously generated in the cardiovascular system. Recently, the physiological effects of endogenous SO2 were confirmed. Vascular structural remodeling (VSR), an important pathological change in many cardiovascular diseases, plays a crucial role in the pathogenesis of the ...
Jia Liu, Yaqian Huang, Selena Chen, Chaoshu Tang, Hongfang Jin, Junbao Du, Guangdong Yang   +6 more
wiley   +1 more source

HSP27 Inhibits Homocysteine‐Induced Endothelial Apoptosis by Modulation of ROS Production and Mitochondrial Caspase‐Dependent Apoptotic Pathway

BioMed Research International, Volume 2016, Issue 1, 2016., 2016
Objectives. Elevated plasma homocysteine (Hcy) could lead to endothelial dysfunction and is viewed as an independent risk factor for atherosclerosis. Heat shock protein 27 (HSP27), a small heat shock protein, is reported to exert protective effect against atherosclerosis. This study aims to investigate the protective effect of HSP27 against Hcy‐induced
Xin Tian, Lei Zhao, Xianjing Song, Youyou Yan, Ning Liu, Tianyi Li, Bingdi Yan, Bin Liu, Cheng I. Cheng   +8 more
wiley   +1 more source

Synthesis of dichloroacetamides and study of their anti-tumor activity

Фармацевтичний журнал, 2022
Dichloroacetic acid and its derivatives exhibit the properties of metabolic cytoprotectors and apoptosis inducers. Nowadays evaluation of these derivatives is being conducted regarding the induction of immunogenic cell death.
L. M. Havryshchuk, V. Ya. Horishny, R. B. Lesyk   +2 more
doaj   +1 more source

Stem Cells and Regenerative Medicine: Myth or Reality of the 21th Century

Stem Cells International, Volume 2015, Issue 1, 2015., 2015
Since the 1960s and the therapeutic use of hematopoietic stem cells of bone marrow origin, there has been an increasing interest in the study of undifferentiated progenitors that have the ability to proliferate and differentiate into various tissues. Stem cells (SC) with different potency can be isolated and characterised.
J.-F. Stoltz, N. de Isla, Y. P. Li, D. Bensoussan, L. Zhang, C. Huselstein, Y. Chen, V. Decot, J. Magdalou, N. Li, L. Reppel, Y. He, Juan Carlos Casar   +12 more
wiley   +1 more source