Results 11 to 20 of about 52,861 (267)
Micromachines, 2020 In this study, we developed a modified glassy carbon electrode (GCE) with graphene oxide, multi-walled carbon nanotube hybrid nanocomposite in chitosan (GCE/GO-MWCNT-CHT) to achieve simultaneous detection of four nucleobases (i.e., guanine (G), adenine ...
Shuting Wang +3 more
doaj +1 more source
Revisiting the Neutral Dynamics Derived Limiting Guanine-Cytosine Content Using the Human De Novo Point Mutation Data [PDF]
Meta Gene 31: 100994 (2022), 2020 We revisit the topic of human genome guanine-cytosine content under neutral evolution. For this study, the de novo mutation data within human is used to estimate mutational rate instead of using base substitution data between related species. We then define a new measure of mutation bias which separate the de novo mutation counts from the background ...
arxiv +1 more source
Evaluation and Minimization of Cas9-Independent Off-Target DNA Editing by Cytosine Base Editors
Nature Biotechnology, 2020 Cytosine base editors (CBEs) enable targeted C•G-to-T•A conversions in genomic DNA. Recent studies report that BE3, the original CBE, induces a low frequency of genome-wide Cas9-independent off-target C•G-to-T•A mutation in mouse embryos and in rice ...
Jordan L. Doman +3 more
semanticscholar +1 more source
Molecules, 2021 Thymine DNA Glycosylase (TDG) is an enzyme of the base excision repair mechanism and removes damaged or mispaired bases from DNA via hydrolysis of the glycosidic bond. Specificity is of high importance for such a glycosylase, so as to avoid the damage of
Senta Volkenandt +2 more
doaj +1 more source
Frontiers in Chemistry, 2020 i-Motifs are four-stranded DNA structures formed from sequences rich in cytosine, held together by hemi-protonated cytosine-cytosine base pairs. These structures have been utilized extensively as pH-switches in DNA-based nanotechnology.
Mahmoud A. S. Abdelhamid +3 more
doaj +1 more source
Femtosecond Intersystem Crossing in the DNA Nucleobase Cytosine [PDF]
J. Phys. Chem. Lett. 2012, 3, 21, 3090-3095, 2021 Ab initio molecular dynamics including non-adiabatic and spin-orbit couplings on equal footing is used to unravel the deactivation of cytosine after UV light absorption. Intersystem crossing (ISC) is found to compete directly with internal conversion in tens of femtoseconds, thus making cytosine the organic compound with the fastest triplet population ...
arxiv +1 more source
Crystals, 2020 To date, despite the crucial role played by cytosine, uracil, and thymine in the DNA/RNA replication process, no examples showing isomorphic and isostructural behavior among binary co-crystals of natural or modified pyrimidine nucleobases have been so ...
Gustavo Portalone
doaj +1 more source
Adsorption of Nucleic Acid Bases, Ribose, and Phosphate by Some Clay Minerals
Life, 2015 Besides having a large capacity for taking up organic molecules, clay minerals can catalyze a variety of organic reactions. Derived from rock weathering, clay minerals would have been abundant in the early Earth. As such, they might be expected to play a
Hideo Hashizume
doaj +1 more source
Frontiers in Chemistry, 2018 Cytosine, a DNA and RNA building-block, and Metformin, the most widely prescribed drug for the treatment of Type 2 Diabetes mellitus were made to react separately with ammonium or sodium metavanadates in acidic aqueous solutions to obtain two ...
Eduardo Sánchez-Lara +7 more
doaj +1 more source
Cytosine base editor generates substantial off-target single-nucleotide variants in mouse embryos
Science, 2019 Spotting off-targets from gene editing Unintended genomic modifications limit the potential therapeutic use of gene-editing tools. Available methods to find off-targets generally do not work in vivo or detect single-nucleotide changes.
Erwei Zuo +9 more
semanticscholar +1 more source