Results 11 to 20 of about 279,378 (380)

Cytosine methylation of mature microRNAs inhibits their functions and is associated with poor prognosis in glioblastoma multiforme

Molecular Cancer, 2020
Background Literature reports that mature microRNA (miRNA) can be methylated at adenosine, guanosine and cytosine. However, the molecular mechanisms involved in cytosine methylation of miRNAs have not yet been fully elucidated.
Mathilde Cheray, Amandine Etcheverry, Camille Jacques, Romain Pacaud, Gwenola Bougras-Cartron, Marc Aubry, Florent Denoual, Pierre Peterlongo, Arulraj Nadaradjane, Joséphine Briand, Farida Akcha, Dominique Heymann, François M. Vallette, Jean Mosser, Benjamin Ory, Pierre-François Cartron   +15 more
doaj   +2 more sources

Ureido cytosine and cytosine-containing acrylic copolymers

Polymer Chemistry, 2016
Ureido-cytosine pendant groups contributed to random acrylic copolymers with enhanced thermomechanical performance, well-defined morphologies, and reduced water uptake.
Keren Zhang, Mingtao Chen, Kevin J. Drummey, Samantha J. Talley, Lindsey J. Anderson, Robert B. Moore, Timothy E. Long   +6 more
openaire   +3 more sources

Global DNA cytosine methylation as an evolving trait: phylogenetic signal and correlated evolution with genome size in Angiosperms

Frontiers in Genetics, 2015
DNA cytosine methylation is a widespread epigenetic mechanism in eukaryotes, and plant genomes commonly are densely methylated. Genomic methylation can be associated with functional consequences such as mutational events, genomic instability or altered ...
Conchita eAlonso, Ricardo ePérez, Pilar eBazaga, Carlos M Herrera   +3 more
doaj   +2 more sources

Detection of Cytosine methylation in ancient DNA from five native american populations using bisulfite sequencing.

PLoS ONE, 2015
While cytosine methylation has been widely studied in extant populations, relatively few studies have analyzed methylation in ancient DNA. Most existing studies of epigenetic marks in ancient DNA have inferred patterns of methylation in highly degraded ...
Rick W A Smith, Cara Monroe, Deborah A Bolnick   +2 more
doaj   +2 more sources

Cytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activity

Nature Communications, 2020
Cytosine base editors (CBEs) enable efficient, programmable reversion of T•A to C•G point mutations in the human genome. Recently, cytosine base editors with rAPOBEC1 were reported to induce unguided cytosine deamination in genomic DNA and cellular RNA ...
Yi Yu, Thomas C. Leete, D. Born, Lauren E. Young, Luis A. Barrera, Seung-Joo Lee, H. Rees, G. Ciaramella, Nicole M. Gaudelli   +8 more
semanticscholar   +2 more sources

Cytosine-to-Uracil Deamination by SssI DNA Methyltransferase [PDF]

, 2013
The prokaryotic DNA(cytosine-5)methyltransferase M.SssI shares the specificity of eukaryotic DNA methyltransferases (CG) and is an important model and experimental tool in the study of eukaryotic DNA methylation.
A Beletskii, A Jeltsch, AN Sharath, Antal Kiss, AS Yang, B Bandaru, B Bandaru, B Chaikind, BM Hall, BTF van der Gun, DM Woodcock, EA Raleigh, EU Selker, EV Koudan, G Pósfai, GL Xu, H Gowher, I Stier, Ildikó Stier, J Sambrook, JC Shen, JC Shen, JC Shen, JM Zingg, JM Zingg, KM Reinisch, LA Frederico, LM Guzman, M Frommer, M Wyszynski, Martin G. Marinus, MH Sibley, P Rathert, P Renbaum, PA Waite-Rees, PM Warnecke, R Métivier, R Shapiro, RJ Roberts, RY-H Wang, S Kumar, SE Luria, T Durfee, TA Kunkel, UT Sankpal, WA Rosche, X Cheng, X Zhang   +47 more
core   +3 more sources

Decavanadate Salts of Cytosine and Metformin: A Combined Experimental-Theoretical Study of Potential Metallodrugs Against Diabetes and Cancer

Frontiers in Chemistry, 2018
Cytosine, a DNA and RNA building-block, and Metformin, the most widely prescribed drug for the treatment of Type 2 Diabetes mellitus were made to react separately with ammonium or sodium metavanadates in acidic aqueous solutions to obtain two ...
Eduardo Sánchez-Lara, Samuel Treviño, Brenda L. Sánchez-Gaytán, Enrique Sánchez-Mora, María Eugenia Castro, Francisco J. Meléndez-Bustamante, Miguel A. Méndez-Rojas, Enrique González-Vergara   +7 more
doaj   +1 more source

Excited States of Proton-bound DNA/RNA Base Homo-dimers: Pyrimidines [PDF]

, 2014
We are presenting the electronic photo fragment spectra of the protonated pyrimidine DNA bases homo-dimers. Only the thymine dimer exhibits a well structured vibrational progression, while protonated monomer shows broad vibrational bands. This shows that
Adesokan A. a, Ahlrichs R., Alata I., Alata I., Alata I., Alata I., Andersen L. H., Bakker J. M., Berdakin M., Berdakin M., Bouchoux G., Boyarkin O. V., Brøndsted Nielsen S., Chakraborty S., Christophe Jouvet, Claude Dedonder-Lardeux, Delchev V. B., Dopfer O., Duncan M. A., Fonseca Guerra C., Fridgen T. D., Féraud G., Féraud G., Gehring K., Grégoire G., Gustavo A. Pino, Géraldine Féraud, Góra R. W., Hattig C., Kamrath M. Z., Kamrath M. Z., Kang H., Kang H., Kang H., Kleinermanns K., Le Barbu-Debus K., Lepere V., Lieblein A. L., Marian C., Matias Berdakin, Mercier S. R., Patzer A., Pino G. A., Rajabi K., Saigusa H., Salpin J.-Y., Schermann J.-P., Schirmer J., Scuderi D., Scuderi D., Sobolewski A. L., Solcà N., Wang X. B., Yang B., Yang B., Škríba A.   +55 more
core   +4 more sources

Hydrogen-bonding patterns in bis(cytosinium) tartarate monohydrate

IUCrData, 2017
The asymmetric unit of the title cystosinium salt derivative, 2C4H6N3O+·C4H4O62−·H2O, contains two cytosinium cations, one tartaric acid anion and a water molecule. The two cytosinium cations are almost planar (r.m.s. deviations of the fitted atoms are 0.
P. Jaikumar, T. V. Sundar, N. Sharmila, T. Balakrishnan, K. Ramamurthi   +4 more
doaj   +1 more source

Use of the Illumina EPIC methylation array for epigenomic research in the crab‐eating macaque (Macaca fascicularis)

Neuropsychopharmacology Reports, 2020
Background Commercially available Illumina DNA methylation arrays (HumanMethylation 27K, HumanMethylation450, and MethylationEPIC BeadChip) can be used for comprehensive DNA methylation analyses of not only the human genome but also other mammalian ...
Yutaka Nakachi, Kazuhiro Ishii, Miki Bundo, Tomoyuki Masuda, Kazuya Iwamoto   +4 more
doaj   +1 more source