Results 221 to 230 of about 279,378 (380)

New insights into applications of base editor in hereditary disorders

Interdisciplinary Medicine, EarlyView.
Abstract Hereditary disorders are a group of diseases caused by genetic mutations or chromosomal variations. Although the incidence of each genetic disorder is relatively low, patients affected by the disease generally experience a range of severe symptoms, including blindness, disability, and even premature death. In addition, the available treatments
Maoping Cai, Linhui Zhang, Liqing Li, Yue Liu, Canbin Lv, Yan Shi, Jianyuan Zhao, Dingwei Ye, Yuanyuan Qu   +8 more
wiley   +1 more source

Defect-Engineered Graphene Nanoribbons for Enhanced DNA Sequencing: A Study of Structural Defects and Their Impact on Nucleobase Interaction and Quantum Transport. [PDF]

J Phys Chem B
Kumawat RL, Jha SK, Tayo BO, Sherrill CD.   +3 more
europepmc   +1 more source

mtFFPECleaner: A high‐fidelity machine learning approach for artifact removal in high‐throughput mitochondrial DNA sequencing data of archival formalin‐fixed paraffin‐embedded specimens

Interdisciplinary Medicine, EarlyView.
mtFFPECleaner is a high‐fidelity machine learning framework designed to remove formalin‐induced artifacts in mitochondrial DNA sequencing data from formalin‐fixed paraffin‐embedded (FFPE) tissue samples. Using paired FFPE‐fresh‐frozen samples, the model distinguishes genuine mtDNA mutations from artifacts through feature extraction and random forest ...
Shengjing Li, Wenjie Guo, Tianlei Sun, Fanfan Xie, Fan Peng, Kaixiang Zhou, Zhangwen Lei, Xu Guo, Yang Liu, Jinliang Xing   +9 more
wiley   +1 more source

Central Nervous System Involvement as the Initial Manifestation of Transthyretin Amyloidosis: A Case Report and Literature Review

iRADIOLOGY, EarlyView.
We reported a patient who presented with transient focal neurological symptoms. The contrast‐enhanced brain magnetic resonance imaging (MRI) of this patient demonstrated significant enhancement of the dura mater, pia mater, and spinal meninges. Based on the positive result of single photon emission computed tomography (SPECT), we promptly determined ...
Fen Li, Mingsheng Wan, Benjian Sun, Lijia Zou, Huan Yang, Jing Li, Si Chen   +6 more
wiley   +1 more source

Tuning i-motif folding and stability with acyclic phosphonate-linked (ZNA) cytidine residues. [PDF]

RSC Adv
Derden M, Reynders S, Rihon J, Li X, Coosemans F, Rozenski J, Herdewijn P, Groaz E, Lescrinier E.   +8 more
europepmc   +1 more source

High-dose cytosine arabinoside and mitoxantrone: a highly effective regimen in refractory acute myeloid leukemia [PDF]

, 1987
Wolfgang Hiddemann, H. Kreutzmann, Kurt Straíf, WD Ludwig, R Mertelsmann, R Donhuijsen- Ant, Eva Lengfelder, Z Arlin, T Buchner   +8 more
openalex   +1 more source

Nanomaterial‐Enhanced Electrochemical Sensors for Clinical Monitoring of Acyclovir: Integration Into Molecular Diagnostics

Journal of Clinical Laboratory Analysis, EarlyView.
Schematic illustration of biosensor technology for detection of ACV. ABSTRACT Objective This study investigates the innovative application of nanomaterial‐based micro‐devices aimed at enhancing the diagnosis and management of acyclovir (ACV) for herpes virus infections, specifically those caused by HSV‐1, HSV‐2, CMV, and VZV.
Mohammad Darvishi, Mohammad Mahdi Heidari, Reza Kheradmand, Nava Moghadasian Niaki, Mahsa Tabean, Ahmad Mobed   +5 more
wiley   +1 more source

Distinct roles of TET-mediated cytosine oxidation in neural stem cell fate decisions. [PDF]

Stem Cell Reports
Ram O.
europepmc   +1 more source

A Convenient Synthesis of Cytosine Nucleosides

, 1972
Masakatsu Kaneko, Bunji Shimizu
openalex   +2 more sources

Noncanonical Nucleotides in the Genome Around the Maternal‐Zygotic Transition

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
In this paper, Kazzazi et al. provide a comprehensive review of the dynamics of nonconventional nucleotides in the genome during early developmental stages, hypothesizing a potential role for these nucleotides in the activation of the zygotic genome. ABSTRACT From the very moment of fertilization and throughout development, the cells of animal embryos ...
Latifa Kazzazy, Dávid Mező, Kinga K. Nagy, Viktória Perey‐Simon, Judit Tóth, Angéla Békési, Beáta Vértessy, Máté Varga   +7 more
wiley   +1 more source