Results 31 to 40 of about 279,378 (380)
Rewriting Human History and Empowering Indigenous Communities with Genome Editing Tools. [PDF]
, 2020 Appropriate empirical-based evidence and detailed theoretical considerations should be used for evolutionary explanations of phenotypic variation observed in the field of human population genetics (especially Indigenous populations). Investigators within
Fox, Keolu +2 more
core +2 more sources
Molecules, 2019 The clinically widely-used anticancer drug, cisplatin, binds strongly to DNA as a DNA-damaging agent. Herein, we investigated the interaction of cisplatin with a 15-mer single-stranded C,T-rich oligodeoxynucleotide, 5′-CCTT4CTT7G8C9T10TCTCC-3′
Wenjuan Zeng +9 more
doaj +1 more source
Clinical presentation, diagnostic findings and outcome of dogs with presumptive spinal-only meningoencephalomyelitis of unknown origin [PDF]
, 2017 Objectives: To summarise clinical presentation, diagnostic findings and long-term outcome for dogs clinically diagnosed with meningoencephalomyelitis of unknown origin affecting the spinal cord alone.
Cardy +13 more
core +1 more source
CGGBP1-regulated cytosine methylation at CTCF-binding motifs resists stochasticity
BMC Genetics, 2020 Background The human CGGBP1 binds to GC-rich regions and interspersed repeats, maintains homeostasis of stochastic cytosine methylation and determines DNA-binding of CTCF.
Manthan Patel +3 more
doaj +1 more source
Cytosine Methyltransferases as Tumor Markers [PDF]
Current Genomics, 2010 Changes in DNA methylation patterns is a prominent characteristic of human tumors. Tumor cells display reduced levels of genomic DNA methylation and site-specific CpG island hypermethylation. Methylation of CpG dinucleotides is catalyzed by the enzyme family of DNA methyltransferases (DNMTs). In this review, the role of DNA methylation and DNMTs as key
Kossida, Sophia, Pavlopoulou, ATHANASIA
openaire +4 more sources
Cytosine Methylation: Remaining Faithful [PDF]
Current Biology, 2008 DNA methyltransferase-1 (DNMT1) has a higher specific activity on hemimethylated DNA than on unmethylated DNA, but this preference is too small to explain the faithful mitotic inheritance of genomic methylation patterns. New genetic studies in plants and mammals have identified a novel factor that increases the fidelity of maintenance methylation.
Timothy H. Bestor, Steen K.T. Ooi
openaire +3 more sources
A cytosine deaminase for programmable single-base RNA editing
Science, 2019 Adding to the RNA editing toolbox A previously developed RNA editing system called REPAIR can base edit A to I in RNA by fusing the adenine deaminase domain of ADAR2 with catalytically dead CRISPR-Cas13.
Omar O. Abudayyeh +9 more
semanticscholar +1 more source
Communication: UV photoionization of cytosine catalyzed by Ag+ [PDF]
, 2015 The photo-induced damages of DNA in interaction with metal cations, which are found in various environments, still remain to be characterized. In this paper, we show how the complexation of a DNA base (cytosine (Cyt)) with a metal cation (Ag+) changes ...
Bertran J. +8 more
core +3 more sources
Enzymatic Cytosine Deamination [PDF]
Molecular Cell, 2002 AID and Apobec proteins have several, normally beneficial cellular functions. It has now been discovered that they act as DNA mutators in E. coli by deaminating cytosine in DNA. Thus, they may produce genome instability in mammals if not controlled.
Thomas A. Kunkel, Marilyn Diaz
openaire +3 more sources
Epigenetics, 2021 The presence of 5-hydroxymethyl cytosine in DNA has been previously associated with ageing. Using in silico analysis of normal liver samples we presently observed that in 5-hydroxymethyl cytosine sequences, DNA methylation is dependent on the co-presence
Andigoni Malousi +2 more
doaj +1 more source