Results 11 to 20 of about 307,661 (330)

Higher Incidence of B Cell Malignancies in Primary Immunodeficiencies: A Combination of Intrinsic Genomic Instability and Exocytosis Defects at the Immunological Synapse

Frontiers in Immunology, 2020
Congenital defects of the immune system called primary immunodeficiency disorders (PID) describe a group of diseases characterized by a decrease, an absence, or a malfunction of at least one part of the immune system.
Jérôme Mastio, Mezida B. Saeed, Hannah Wurzer, Max Krecke, Lisa S. Westerberg, Clément Thomas   +5 more
doaj   +1 more source

Bhalin, an Essential Cytoskeleton-Associated Protein of Trypanosoma brucei Linking TbBILBO1 of the Flagellar Pocket Collar with the Hook Complex

Microorganisms, 2021
Background: In most trypanosomes, endo and exocytosis only occur at a unique organelle called the flagellar pocket (FP) and the flagellum exits the cell via the FP.
Christine E. Broster Reix, Célia Florimond, Anne Cayrel, Amélie Mailhé, Corentin Agnero-Rigot, Nicolas Landrein, Denis Dacheux, Katharina Havlicek, Mélanie Bonhivers, Brooke Morriswood, Derrick R. Robinson   +10 more
doaj   +1 more source

The LisH Domain-Containing N-Terminal Fragment is Important for the Localization, Dimerization, and Stability of Katnal2 in Tetrahymena

Cells, 2020
Katanin-like 2 protein (Katnal2) orthologs have a tripartite domain organization. Two highly conserved regions, an N-terminal LisH (Lis-homology) domain and a C-terminal AAA catalytic domain, are separated by a less conserved linker.
Ewa Joachimiak, Ewa Waclawek, Michal Niziolek, Anna Osinka, Hanna Fabczak, Jacek Gaertig, Dorota Wloga   +6 more
doaj   +1 more source

Quantitative analysis of the effect of microtubule-targeting drugs on the microtubule cytoskeleton of breast cancer cells with different invasive properties

Comptes Rendus. Chimie, 2023
The characterization of microtubule-targeting drugs at the cellular level is an essential step in the development of drugs targeting the microtubule network.
Michallet, Sophie, Bosc, Lauriane, Lafanechère, Laurence   +2 more
doaj   +1 more source

Mechanical regulation of glycolysis via cytoskeleton architecture

Nature, 2020
The mechanics of the cellular microenvironment continuously modulates cell functions such as growth, survival, apoptosis, differentiation and morphogenesis via cytoskeletal remodelling and actomyosin contractility 1 – 3 .
Jin Suk Park, C. Burckhardt, R. Lazcano, L. Solis, T. Isogai, Linqing Li, Christopher S. Chen, B. Gao, J. Minna, R. Bachoo, R. Deberardinis, G. Danuser   +11 more
semanticscholar   +1 more source

Targeting the cytoskeleton to direct pancreatic differentiation of human pluripotent stem cells

Nature Biotechnology, 2020
Generation of pancreatic β cells from human pluripotent stem cells (hPSCs) holds promise as a cell replacement therapy for diabetes. In this study, we establish a link between the state of the actin cytoskeleton and the expression of pancreatic ...
N. Hogrebe, Punn Augsornworawat, Kristina G. Maxwell, Leonardo Velazco-Cruz, J. Millman   +4 more
semanticscholar   +1 more source

Posttranslational modifications of the cytoskeleton

Cytoskeleton, 2021
The cytoskeleton plays important roles in many essential processes at the cellular and organismal levels, including cell migration and motility, cell division, and the establishment and maintenance of cell and tissue architecture.
Brittany MacTaggart, A. Kashina
semanticscholar   +1 more source

Visualization of Endothelial Actin Cytoskeleton in the Mouse Retina [PDF]

, 2012
Angiogenesis requires coordinated changes in cell shape of endothelial cells (ECs), orchestrated by the actin cytoskeleton. The mechanisms that regulate this rearrangement in vivo are poorly understood - largely because of the difficulty to visualize ...
Alessia Fraccaroli, Attila Aszodi, Claudio A Franco, Eloi Montanez, Emanuel Rognoni, Filipa Neto, Holger Gerhardt, Holger Gerhardt, Markus Rehberg, Roland Wedlich-Söldner, Ulrich Pohl   +10 more
core   +16 more sources

Intrinsic Resistance of Chronic Lymphocytic Leukemia Cells to NK Cell-Mediated Lysis Can Be Overcome In Vitro by Pharmacological Inhibition of Cdc42-Induced Actin Cytoskeleton Remodeling

Frontiers in Immunology, 2021
Natural killer (NK) cells are innate effector lymphocytes with strong antitumor effects against hematologic malignancies such as chronic lymphocytic leukemia (CLL). However, NK cells fail to control CLL progression on the long term.
Hannah Wurzer, Hannah Wurzer, Liza Filali, Céline Hoffmann, Max Krecke, Max Krecke, Andrea Michela Biolato, Andrea Michela Biolato, Jérôme Mastio, Sigrid De Wilde, Jean Hugues François, Anne Largeot, Guy Berchem, Guy Berchem, Jérôme Paggetti, Etienne Moussay, Clément Thomas   +16 more
doaj   +1 more source

The Bacterial Cytoskeleton [PDF]

CBE—Life Sciences Education, 2006
One of the pleasures of teaching introductory biology courses is learning new things about old, familiar subjects … such as the differences between eukaryotes and prokaryotes. For a eukaryotic cell biologist, such learning usually entails examining how bacteria function, in ways other than how they replicate and transcribe DNA and how they synthesize ...
Lawrence Rothfield, Yu-Ling Shih
openaire   +7 more sources