Results 31 to 40 of about 307,661 (330)

Modelling host-Trypanosoma brucei gambiense interactions in vitro using human induced pluripotent stem cell-derived cortical brain organoids [version 2; peer review: 2 approved]

open access: yesF1000Research, 2023
Background: Sleeping sickness is caused by the extracellular parasite Trypanosoma brucei and is associated with neuroinflammation and neuropsychiatric disorders, including disruption of sleep/wake patterns, and is now recognised as a circadian disorder ...
Juan F. Quintana   +4 more
doaj   +1 more source

Intracellular mechanochemical waves in an active poroelastic model [PDF]

open access: yes, 2013
Many processes in living cells are controlled by biochemical substances regulating active stresses. The cytoplasm is an active material with both viscoelastic and liquid properties. We incorporate the active stress into a two-phase model of the cytoplasm
Alonso Muñoz, Sergio   +3 more
core   +2 more sources

Mast Cell Activation and Microtubule Organization Are Modulated by Miltefosine Through Protein Kinase C Inhibition

open access: yesFrontiers in Immunology, 2018
Mast cells play an effector role in innate immunity, allergy, and inflammation. Antigen-mediated activation of mast cells initiates signaling events leading to Ca2+ response and the release of inflammatory and allergic mediators from granules.
Zuzana Rubíková   +3 more
doaj   +1 more source

Regulation of the Actin Cytoskeleton in Podocytes

open access: yesCells, 2020
Podocytes are an integral part of the glomerular filtration barrier, a structure that prevents filtration of large proteins and macromolecules into the urine.
J. Blaine, James F Dylewski
semanticscholar   +1 more source

STORM imaging reveals the spatial arrangement of transition zone components and IFT particles at the ciliary base in Tetrahymena

open access: yesScientific Reports, 2021
The base of the cilium comprising the transition zone (TZ) and transition fibers (TF) acts as a selecting gate to regulate the intraflagellar transport (IFT)-dependent trafficking of proteins to and from cilia.
Khodor S. Hazime   +5 more
doaj   +1 more source

First-in-Class Colchicine-Based Visible Light Photoswitchable Microtubule Dynamics Disrupting Agent

open access: yesCells, 2023
Compounds that disrupt microtubule dynamics, such as colchicine, paclitaxel, or Vinca alkaloids, have been broadly used in biological studies and have found application in clinical anticancer medications.
Filip Borys   +4 more
doaj   +1 more source

Kinetochore- and chromosome-driven transition of microtubules into bundles promotes spindle assembly

open access: yesNature Communications, 2022
Mitotic spindle assembly is not fully understood. This work reveals that kinetochores drive the coarsening of a uniform microtubule array into bundles, which promote spindle formation and chromosome segregation fidelity.
Jurica Matković   +6 more
doaj   +1 more source

The Cytoskeleton—A Complex Interacting Meshwork

open access: yesCells, 2019
The cytoskeleton of animal cells is one of the most complicated and functionally versatile structures, involved in processes such as endocytosis, cell division, intra-cellular transport, motility, force transmission, reaction to external forces, adhesion
T. Hohmann, F. Dehghani
semanticscholar   +1 more source

Regulation of actin cytoskeleton via photolithographic micropatterning

open access: yesJournal of Innovative Optical Health Sciences, 2023
Actin cytoskeleton plays crucial roles in various cellular functions. Extracellular matrix (ECM) can modulate cell morphology by remodeling the internal cytoskeleton.
Fulin Xing   +9 more
doaj   +1 more source

Johnson-Kendall-Roberts theory applied to living cells [PDF]

open access: yes, 2005
Johnson-Kendall-Roberts (JKR) theory is an accurate model for strong adhesion energies of soft slightly deformable material. Little is known about the validity of this theory on complex systems such as living cells. We have addressed this problem using a
A. S. G. Curtis   +15 more
core   +4 more sources

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