Results 41 to 50 of about 307,661 (330)

Intrinsic and Extrinsic Factors Affecting Microtubule Dynamics in Normal and Cancer Cells

Molecules, 2020
Microtubules (MTs), highly dynamic structures composed of α- and β-tubulin heterodimers, are involved in cell movement and intracellular traffic and are essential for cell division.
Filip Borys, Ewa Joachimiak, Hanna Krawczyk, Hanna Fabczak   +3 more
doaj   +1 more source

Prognostic significance of CKAP2L expression in patients with clear cell renal cell carcinoma

Frontiers in Genetics, 2023
Background: Cytoskeleton-associated protein 2-like protein (CKAP2L) is thought to promote the progression of glioma, breast cancer, and ovarian cancer. However, the role of cytoskeleton-associated protein 2-like protein in clear cell renal cell carcinoma
Zhi Liu, Jun Zhang, Deyun Shen, Xuechun Hu, Zongpan Ke, I Nyoman Ehrich Lister, Bungaran Sihombing   +6 more
doaj   +1 more source

Cytoskeleton—a crucial key in host cell for coronavirus infection

Journal of Molecular Cell Biology, 2020
The emerging coronavirus (CoV) pandemic is threatening the public health all over the world. Cytoskeleton is an intricate network involved in controlling cell shape, cargo transport, signal transduction, and cell division.
Zeyu Wen, Yue Zhang, Zhekai Lin, Kun Shi, Yaming Jiu   +4 more
semanticscholar   +1 more source

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

Cells, 2019
The immune system is a fundamental part of the tumor microenvironment. In particular, cytotoxic lymphocytes, such as cytolytic T cells and natural killer cells, control tumor growth and disease progression by interacting and eliminating tumor cells.
Hannah Wurzer, Céline Hoffmann, Antoun Al Absi, Clément Thomas   +3 more
doaj   +1 more source

A New Quantitative Cell-Based Assay Reveals Unexpected Microtubule Stabilizing Activity of Certain Kinase Inhibitors, Clinically Approved or in the Process of Approval

Frontiers in Pharmacology, 2020
Agents able to modify microtubule dynamics are important anticancer drugs. The absence of microtubules resulting from drug-induced depolymerization is easy to detect.
Sacnicte Ramirez-Rios, Sophie Michallet, Leticia Peris, Caroline Barette, Clotilde Rabat, Yangbo Feng, Marie-Odile Fauvarque, Annie Andrieux, Karin Sadoul, Laurence Lafanechère   +9 more
doaj   +1 more source

The actin-myosin regulatory MRCK kinases: regulation, biological functions and associations with human cancer [PDF]

, 2014
The contractile actin-myosin cytoskeleton provides much of the force required for numerous cellular activities such as motility, adhesion, cytokinesis and changes in morphology.
AP Somlyo, B Rafn, C Gaggioli, C Gally, CL Moncrieff, CS Loo, D Pyeon, DA Heerding, DM Pirone, DR Rhodes, ER Gomes, ET Kimchi, F Corpet, G Brunhofer, G Groeger, H Yamaguchi, HI Lowe, I Tan, I Tan, I Tan, I Tan, I Tan, J Schlingemann, J Schwarz, JM Elkins, JM Herbert, K Ando, K Lefort, KE Fisher, L Huo, L Luo, LJ Veer van’t, LR Pearce, LT Lam, M Jacobs, M Uehata, M Vicente-Manzanares, MA Fabian, MA Ginos, Mathieu Unbekandt, MF Olson, MF Olson, Michael F. Olson, N Nakamura, N Rath, P Basu, P Madaule, PL Podolin, R Cmejla, RW Scott, S Balasenthil, S Wang, S Wilkinson, S Yamamoto, SH Choi, SM Kim, T Heikkila, T Leung, T Sumi, X Liu, Y Hao, Y Ng, Y Zhao   +62 more
core   +1 more source

DNA damage and repair: underlying mechanisms leading to microcephaly

Frontiers in Cell and Developmental Biology, 2023
DNA-damaging agents and endogenous DNA damage constantly harm genome integrity. Under genotoxic stress conditions, the DNA damage response (DDR) machinery is crucial in repairing lesions and preventing mutations in the basic structure of the DNA ...
Jessica Honorato Ribeiro, Jessica Honorato Ribeiro, Nazlican Altinisik, Nicholas Rajan, Mieke Verslegers, Sarah Baatout, Sarah Baatout, Jay Gopalakrishnan, Roel Quintens   +8 more
doaj   +1 more source

A neuronal network of mitochondrial dynamics regulates metastasis. [PDF]

, 2016
The role of mitochondria in cancer is controversial. Using a genome-wide shRNA screen, we now show that tumours reprogram a network of mitochondrial dynamics operative in neurons, including syntaphilin (SNPH), kinesin KIF5B and GTPase Miro1/2 to localize
Aguinaldo, Angeline, Altieri, Dario C., Bosari, Silvano, Bryant, Kelly G., Caino, M. Cecilia, Cohen, Andrew R., Ferrero, Stefano, Gabrilovich, Dmitry I., Hayden, James E., Kossenkov, Andrew V., Languino, Lucia R., Morotti, Annamaria, Seo, Jae Ho, Vaira, Valentina, Wait, Eric   +14 more
core   +3 more sources

Ciliary Proteins: Filling the Gaps. Recent Advances in Deciphering the Protein Composition of Motile Ciliary Complexes

Cells, 2019
Cilia are highly evolutionarily conserved, microtubule-based cell protrusions present in eukaryotic organisms from protists to humans, with the exception of fungi and higher plants.
Anna Osinka, Martyna Poprzeczko, Magdalena M. Zielinska, Hanna Fabczak, Ewa Joachimiak, Dorota Wloga   +5 more
doaj   +1 more source

High-resolution three-dimensional views of membrane-associated clathrin and cytoskeleton in critical-point-dried macrophages. [PDF]

, 1983
We obtained high-resolution topographical information about the distribution of clathrin and cytoskeletal filaments on cytoplasmic membrane surfaces of macrophages spreading onto glass coverslips by both critical-point drying of broken-open cells and ...
Aggeler, J, Takemura, R, Werb, Z
core   +1 more source