Results 41 to 50 of about 322,139 (355)
, 2006 The crowded cytosol is a special environment where weak interactions can be important. Here many macromolecules are close to the limits of their solubility, a condition conducive to weak, but specific, entropy-driven molecular interactions. In addition to being under evolutionary constraint to preserve the functions of their own products, genes ...
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Characterization of the Cytosolic Tuberin-Hamartin Complex [PDF]
Journal of Biological Chemistry, 1999 Tuberous sclerosis (TSC) is an autosomal dominant disorder characterized by a broad phenotypic spectrum that includes seizures, mental retardation, renal dysfunction and dermatological abnormalities. Mutations to either the TSC1 or TSC2 gene are responsible for the disease.
Marjon van Slegtenhorst +5 more
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Recruitment of TBK1 to cytosol‐invading Salmonella induces WIPI2‐dependent antibacterial autophagy
EMBO Journal, 2016 Mammalian cells deploy autophagy to defend their cytosol against bacterial invaders. Anti‐bacterial autophagy relies on the core autophagy machinery, cargo receptors, and “eat‐me” signals such as galectin‐8 and ubiquitin that label bacteria as autophagy ...
Teresa L. M. Thurston +12 more
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Life cycle of cytosolic prions [PDF]
Prion, 2013 Prions are self-templating protein aggregates that were originally identified as the causative agent of prion diseases in mammals, but have since been discovered in other kingdoms. Mammalian prions represent a unique class of infectious agents that are composed of misfolded prion protein.
Hofmann, Julia, Vorberg, Ina
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Efficient Delivery of Quantum Dots into the Cytosol of Cells Using Cell-Penetrating Poly(disulfide)s
Journal of the American Chemical Society, 2017 Quantum dots (QDs) are extremely bright, photostable, nanometer particles broadly used to investigate single molecule dynamics in vitro. However, the use of QDs in vivo to investigate single molecule dynamics is impaired by the absence of an efficient ...
E. Derivery +3 more
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Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing
eLife, 2017 Faithfull genome partitioning during cell division relies on the Spindle Assembly Checkpoint (SAC), a conserved signaling pathway that delays anaphase onset until all chromosomes are attached to spindle microtubules.
Margarida Moura +7 more
doaj +1 more source
Cold Spring Harbor Perspectives in Biology, 2010 "Ca(2+) buffers," a class of cytosolic Ca(2+)-binding proteins, act as modulators of short-lived intracellular Ca(2+) signals; they affect both the temporal and spatial aspects of these transient increases in [Ca(2+)](i). Examples of Ca(2+) buffers include parvalbumins (α and β isoforms), calbindin-D9k, calbindin-D28k, and calretinin.
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FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Diurnal changes of subcellular glutathione content in Arabidopsis thaliana
Biologia Plantarum, 2017 The aim of this study was to investigate diurnal changes of subcellular glutathione content in leaves of Arabidopsis thaliana by immunohistochemistry and quantitative transmission electron microscopy.
B. Zechmann
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Cytosol intermediates in the transport of iron [PDF]
Blood, 1980 Abstract Three 59Fe-labeled nonheme components of the cytosol were identified when rabbit reticuloyctes were incubated with 59Fe-labeled plasma under conditions in which the iron supply was not limiting. Two of these components were identified as ferritin and transferrin.
Edward S. Cole +2 more
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