Results 201 to 210 of about 842,255 (343)

Intersection Between Local Anesthetics and Cancer Biology: What Now? Where Are We Going?

open access: yesAdvanced Biology, EarlyView.
Local anesthetics (LAs), widely used in anesthesia, may also play a role in cancer treatment by inhibiting tumor growth, reducing metastasis, and enhancing immune responses. They modulate key pathways like AKT/mTOR and RAS/ERK while affecting angiogenesis and tumor innervation and the immune response.
Eduardo Nunez‐Rodriguez   +3 more
wiley   +1 more source

Investigating the Cellular Effects of GALC Dosing in Enzyme Replacement Therapy for Krabbe Disease Supports the Role of Nanomedicine

open access: yesAdvanced Biology, EarlyView.
A detailed workflow for recombinant GALC production and characterization is presented to support enzyme replacement therapy for Krabbe disease. In vitro assays demonstrate that physiological GALC doses restore enzymatic activity and autophagic flux without affecting cell viability, whereas higher doses impair autophagy and reduce viability.
Ambra Del Grosso   +5 more
wiley   +1 more source

Antimicrobial Titanium–Copper Alloys: The Role of Microstructure in Arc‐Melted Compositions

open access: yesAdvanced Engineering Materials, EarlyView.
Copper‐containing titanium alloys show promise in combating orthopedic implant infections. This study explores the influence of heat treatment on Ti‐11.5Cu and Ti‐33Cu alloys, revealing that larger Ti2Cu precipitates (≈5 μm) enhance antimicrobial efficacy through increased surface contact. Results suggest contact sterilization is the primary mechanism,
Daisy Rabbitt   +5 more
wiley   +1 more source

New Phenanthrene Derivatives from <i>Cylindrolobus mucronatus</i> Lindl. and their Cytotoxic Activity against Glioblastoma Cells. [PDF]

open access: yesACS Omega
Lae Yee Soe S   +7 more
europepmc   +1 more source

Cytotoxic and agglutinating activities of IgG, IgA, and IgM HLA antibodies.

open access: bronze, 1977
Hayato HASEKURA   +5 more
openalex   +2 more sources

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