Results 101 to 110 of about 745,289 (215)

Strategies in Gene Therapy for Glioblastoma [PDF]

, 2013
Glioblastoma (GBM) is the most aggressive form of brain cancer, with a dismal prognosis and extremely low percentage of survivors. Novel therapies are in dire need to improve the clinical management of these tumors and extend patient survival.
Behera, Prajna, Chiocca, E. Antonio, Kwiatkowska, Aneta, Nandhu, Mohan S., Viapiano, Mariano S.   +4 more
core   +2 more sources

PI3Kδ activation, IL-6 overexpression, and CD37 loss cause resistance to naratuximab emtansine in lymphomas

Blood Advances
: CD37-directed antibody and cellular-based approaches have shown preclinical and promising early clinical activity. Naratuximab emtansine (Debio 1562; IMGN529) is an antibody-drug conjugate (ADC) incorporating an anti-CD37 monoclonal antibody conjugated
Alberto J. Arribas, Sara Napoli, Eugenio Gaudio, Charles Herbaux, Eleonora Cannas, Chiara Tarantelli, Roberta Bordone-Pittau, Luciano Cascione, Nicolas Munz, Luca Aresu, Jacopo Sgrignani, Andrea Rinaldi, Ivo Kwee, Davide Rossi, Andrea Cavalli, Emanuele Zucca, Georg Stussi, Anastasios Stathis, Callum Sloss, Matthew S. Davids, Francesco Bertoni   +20 more
doaj   +1 more source

Enhanced antigen presentation and immunostimulation of dendritic cells using acid-degradable cationic nanoparticles. [PDF]

, 2005
Acid-degradable cationic nanoparticles encapsulating a model antigen (i.e., ovalbumin) were prepared by inverse microemulsion polymerization with acid-cleavable acetal cross-linkers.
Fréchet, Jean MJ, Goh, Sarah L, Kwon, Young Jik, Standley, Stephany M   +3 more
core  

Development and Properties of Valine-Alanine based Antibody-Drug Conjugates with Monomethyl Auristatin E as the Potent Payload

International Journal of Molecular Sciences, 2017
Antibody-drug conjugates (ADCs), designed to selectively deliver cytotoxic agents to antigen-bearing cells, are poised to become an important class of cancer therapeutics.
Yanming Wang, Shiyong Fan, Wu Zhong, Xinbo Zhou, Song Li   +4 more
semanticscholar   +1 more source

Dual enzyme-triggered controlled release on capped nanometric silica mesoporous supports

, 2012
We thank the Spanish Government (project MAT2009-14564-C04 and CTQ2007-64735-AR07) the Generalitat Valencia (project PROMETEO/2009/016) for support. A.A. and L.M.
Angelos, Angelos, Angelos, Aznar, Aznar, Aznar, Beck, Bernardos, Bernardos, Cabrera, Casasús, Casasús, Chen, Climent, Climent, Coll, Du, Felix, Ferris, Fujiwara, Giri, Goldcamp, Kickelbick, Knežević, Knežević, Lin, Liu, Liu, Lytle, Mal, Mal, Nguyen, Park, Park, Park, Patel, Radu, Saha, Schlossbauer, Thornton, Torney, Trewyn, Trewyn, Wight, Yang, Zhu   +45 more
core   +1 more source

Mesoporous silica-coated gold nanostars with drug payload for combined chemo-photothermal cancer therapy

Journal of drug targeting (Print), 2018
Combined chemo-photothermal therapy is attracting increasing attention in the treatment of cancers. In this work, PEGylated mesoporous SiO2-coated gold nanostars (GNS@mSiO2-PEG) were synthesised without using the cytotoxic surfactant ...
Gaoxing Su, Dandan Miao, Yanyan Yu, Min Zhou, P. Jiao, Xiaolong Cao, B. Yan, Hongyan Zhu   +7 more
semanticscholar   +1 more source

Payload-delivering engineered γδ T cells display enhanced cytotoxicity, persistence, and efficacy in preclinical models of osteosarcoma

Science Translational Medicine
T cell–based cancer immunotherapy has typically relied on membrane-bound cytotoxicity enhancers such as chimeric antigen receptors expressed in autologous αβ T cells. These approaches are limited by tonic signaling of synthetic constructs and costs associated with manufacturing. γδ T cells are an emerging alternative for cellular therapy, having innate
Daniel Fowler, Marta Barisa, Alba Southern, Callum Nattress, Elizabeth Hawkins, Eleni Vassalou, Angeliki Kanouta, John Counsell, Enrique Rota, Petra Vlckova, Benjamin Draper, Tessa De Mooij, Andrea Farkas, Helena Brezovjakova, Alfie T. Baker, Katia Scotlandi, Maria C. Manara, Chris Tape, Kerry Chester, John Anderson, Jonathan Fisher   +20 more
openaire   +3 more sources

Inulin for Cancer Therapy: Present and Perspectives [PDF]

, 2016
Inulin is an extremely adaptable polysaccharides consisting of glucopyranose end-capped (\u3b2-1,2) fructose repeating units and, as it is, can be classified as an inherently multifunctional polymeric scaffold.
Giammona, G., Mauro, N., Scialabba, C.
core  

The Impact of Conjugation Mode and Site on Tubulysin Antibody‐Drug‐Conjugate Efficacy and Stability

ChemistryOpen
Antibody‐drug conjugates (ADCs) represent a prominent class of biotherapeutics engineered to selectively deliver cytotoxic payloads to tumors, thereby facilitating targeted cell killing.
Sayumi Yamazoe, Qinqin Cheng, Srikanth Kotapati, Vangipuram S. Rangan, Mei‐Chen Sung, Madhura Deshpande, Aarti Jashnani, Cong Qiang, Michael J. Smith, Chin Pan, Gavin Dollinger, Arvind Rajpal, Pavel Strop, Chetana Rao   +13 more
doaj   +1 more source

Generation of binder-format-payload conjugate-matrices by antibody chain-exchange

Nature Communications
The generation of antibody-drug conjugates with optimal functionality depends on many parameters. These include binder epitope, antibody format, linker composition, conjugation site(s), drug-to-antibody ratio, and conjugation method.
Vedran Vasic, Steffen Dickopf, Nadine Spranger, Rose-Sophie Rosenberger, Michaela Fischer, Klaus Mayer, Vincent Larraillet, Jack A. Bates, Verena Maier, Tatjana Sela, Bianca Nussbaum, Harald Duerr, Stefan Dengl, Ulrich Brinkmann   +13 more
doaj   +1 more source