Results 41 to 50 of about 2,716,407 (409)

Tailoring CD19xCD3-DART exposure enhances T-cells to eradication of B-cell neoplasms. [PDF]

, 2018
Many patients with B-cell malignancies can be successfully treated, although tumor eradication is rarely achieved. T-cell-directed killing of tumor cells using engineered T-cells or bispecific antibodies is a promising approach for the treatment of ...
Aliberti S, Bareja R, Bonvini E, Bruna R, Brusa D, Chiaretti S, Chichili GR, Cignetti A, Circosta P, Deaglio S, Elemento O, Elia AR, Foà R, Giacomo FD, Gottardi D, Guarini AR, Inghirami G., Johnson S, Kyriakides PW, Landra I, Machiorlatti R, Massaia M, Monteleone E, Moore PA, Todaro M   +24 more
core   +1 more source

Selective inhibition of T suppressor-cell function by a monosaccharide [PDF]

, 1981
Interactions between regulatory T lymphocytes and other cells are assumed to occur at the level of the cell surface. T cells which suppress the generation of specifically effector cells have been described as having antigenic, idiotypic, allotypic and I ...
AA Moscona, B Benacerraf, CG Orosz, DH Boldt, DL Peavy, FM Rollwagen, H Lis, IFC McKenzie, J Moss, JE Geltosky, K Eichmann, LA Herzenberg, LB Grabel, LM Nadler, Michael Kramer, RE Rocklin, RM Ferguson, RW Dutton, SH Barondes, T Tada, U Koszinowski, Ulrich H. Koszinowski, VT Marchesi   +22 more
core   +1 more source

Autophagy induced macrophages by α-alumina(α-AL2O3) conjugated cysteine peptidase, enhances the cytotoxic activity of CD8+ T lymphocytes against Leishmania major [PDF]

BioImpacts, 2023
Introduction: Induction of a protective immune response against Leishmania major requires the activation of both TH1 and CD8+ T lymphocytes. Because L. major is an intra-phagosomal parasite, its antigens do not have access to MHC-I.
Fatemeh Beyzay, Ahamad Zavaran Hosseini, Ali Hazrati, Mozhdeh Karimi, Sara Soudi   +4 more
doaj   +1 more source

Fusion of Sendai virus with the target cell membrane is required for T cell cytotoxicity [PDF]

, 1978
INFECTION of mice with viruses can generate cytotoxic T lymphocytes (CTL) which show restricted specificity for target cell lysis. Specific lysis requires that the virus used to prime the target cells must be of the same type as that used to sensitise ...
A Munro, A Scheid, H Tozawa, JW Schrader, K Sugamura, M Homma, MARY-JANE GETHING, MICHAEL WATERFIELD, RM Zinkernagel, U Koszinowski, U Koszinowski, ULRICH KOSZINOWSKI, Y Hosaka   +12 more
core   +1 more source

Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells [PDF]

, 1975
Vaccinia virus specific cytotoxicity against infected target cells was observed in vitro. Spleen lymphocytes from normal and immunized mice of the inbred strains C3H and DBA/2 were incubated with vaccinia virus-infected and non-infected 51Cr-labeled ...
Alkan, Boyum, Brunner, Calder, Cohen, Epstein, Evans, Fulginiti, Gardner, Gardner, Glasgow, Good, Hecht, Janossy, Julius, Koszinowski, Labowskie, Lohmann-Mathes, Lundstedt, Marker, McFarland, Oldstone, Perlmann, Perlmann, Profitt, Schirrmacher, Shearer, Shortman, Speel, Steele, Ueda, Ueda, Von Pirquet, Wagner, Wagner, Zinkernagel, Zinkernagel   +36 more
core   +1 more source

CD8+ T-cell responses in vaccination: Reconsidering targets and function in the context of chronic antigen stimulation [PDF]

, 2018
Cytotoxic CD8 T cells play important roles in eliminating infected and transformed cells. Owing to their potential for therapeutic applications, significant efforts are dedicated toward developing CD8 T cell-based vaccines.
Cosma, Gabriela L., Eisenlohr, Laurence
core   +2 more sources

The relationship between class I binding affinity and immunogenicity of potential cytotoxic T cell epitopes.

Journal of Immunology, 1994
The relationship between binding affinity for HLA class I molecules and immunogenicity of discrete peptide epitopes has been analyzed in two different experimental approaches. In the first approach, the immunogenicity of potential epitopes ranging in MHC
A. Sette, A. Vitiello, B. Reherman, P. Fowler, R. Nayersina, W. Kast, C. Melief, C. Oseroff, L. Yuan, J. Ruppert, J. Sidney, M. D. Guercio, S. Southwood, R. Kubo, R. Chesnut, H. Grey, F. Chisari   +16 more
semanticscholar   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Brander, C., Cohen, D.E., Freedberg, K.A., Goulder, P.J.R., John, M., Johnston, M.N., Kalife, E.T., Le Gall, S., Lee, P.K., Lichterfeld, M., Mallal, S.A., Mothe, B.R., O'Sullivan, K.M., Rosenberg, E.S., Sette, A., Strick, D.A., Walker, B.D., Yu, X.G.   +19 more
core   +2 more sources

Next-Generation Immunotherapies to Improve Anticancer Immunity

Frontiers in Pharmacology, 2021
Checkpoint inhibitors are widely used immunotherapies for advanced cancer. Nonetheless, checkpoint inhibitors have a relatively low response rate, work in a limited range of cancers, and have some unignorable side effects.
Yaoyao Shi, Katarzyna Tomczak, June Li, Joshua K. Ochieng, Younghee Lee, Cara Haymaker   +5 more
doaj   +1 more source

Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus [PDF]

, 1997
A replication-defective recombinant adenovirus (RAd), RAdCMV-CE1, containing core and E1 genes of hepatitis C virus (HCV) was constructed. RAdCMV-CE1 was able to express core and E1 proteins both in mice and human cells.
Borras-Cuesta, F. (Francisco), Bruña-Romero, O. (Oscar), Grace, K. (Ken), Klarke, B. (Berwyn), Lasarte, J.J. (Juan José), Prieto, J. (Jesús), Wilkinson, G. (Gavin)   +6 more
core   +1 more source