Migration of Cytotoxic T Lymphocytes in 3D Collagen Matrices [PDF]
, 2020 To fulfill their killing functions, cytotoxic T lymphocytes (CTLs) need to migrate to search for their target cells in complex biological microenvironments, a key component of which is extracellular matrix (ECM). The mechanisms underlying CTL's navigation are not well understood so far.
arxiv +1 more source
T-cell cytotoxicity in the absence of viral protein synthesis in target cells [PDF]
, 1977 CYTOTOXIC T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompati-bility complex (MHC) which were present during anti-viral sensitisation in ...
A Munro +18 more
core +1 more source
Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma [PDF]
, 2015 Background: Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact.
Bachert, Claus +8 more
core +2 more sources
Journal of Experimental Medicine, 1997 The 4-1BB receptor is an inducible type I membrane protein and member of the tumor necrosis factor receptor (TNFR) superfamily that is rapidly expressed on the surface of CD4+ and CD8+ T cells after antigen- or mitogen-induced activation.
W. Shuford +13 more
semanticscholar +1 more source
Pulsed voltage cold atmospheric plasma jet and gold nanoparticles enhance cytotoxic anticancer effect [PDF]
arXiv, 2023 Efficient and biologically safe mode of cold atmospheric plasma jet (CAPJ) is crucial for the development of CAPJ-based anticancer therapy. In the experiment and numerical simulations, by changing the pulse duration of a positive-pulsed voltage, we found the optimal CAPJ mode with regular streamer propagation.
arxiv
Stochastic model of T Cell repolarization during target elimination (I) [PDF]
, 2020 Cytotoxic T lymphocytes (T) and natural killer (NK) cells are the main cytotoxic killer cells of the human body to eliminate pathogen-infected or tumorigenic cells (i.e. target cells). Once a NK or T cell has identified a target cell, they form a tight contact zone, the immunological synapse (IS).
arxiv +1 more source
Single-cell characterization of leukemic and non-leukemic immune repertoires in CD8(+) T-cell large granular lymphocytic leukemia [PDF]
, 2022 T cell large granular lymphocytic leukemia (T-LGLL) is a rare lymphoproliferative disorder of mature, clonally expanded T cells, where somatic-activating STAT3 mutations are common.
Bhattacharya, Dipabarna +20 more
core +3 more sources
Estimation of In-Vitro Free Radical Scavenging and Cytotoxic Activities of Thiocarbohydrazones Derivatives [PDF]
arXiv, 2023 Objective: To investigate free radical scavenging potential of thiocarbohydrazones derivatives for the discovery of antioxidant compounds of synthetic origin. Method: Eighteen thiocarbohydrazones derivatives were screened for antioxidant activities by using in vitro radical inhibition assay.
arxiv
IFN-γ is required for cytotoxic T cell-dependent cancer genome immunoediting
Nature Communications, 2017 Genetic evolution that occurs during cancer progression enables tumour heterogeneity, thereby fostering tumour adaptation, therapeutic resistance and metastatic potential.
K. Takeda +9 more
semanticscholar +1 more source
Discrete and continuum models for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes and tumour cells [PDF]
arXiv, 2021 We present an individual-based model for the coevolutionary dynamics between CD8+ cytotoxic T lymphocytes (CTLs) and tumour cells. In this model, every cell is viewed as an individual agent whose phenotypic state is modelled by a discrete variable. For tumour cells this variable represents a parameterisation of the antigen expression profiles, while ...
arxiv