Results 41 to 50 of about 823,721 (360)

Target cell-dependent T cell-mediated lysis of vaccinia virus-infected cells [PDF]

, 1975
Vaccinia virus specific cytotoxicity against infected target cells was observed in vitro. Spleen lymphocytes from normal and immunized mice of the inbred strains C3H and DBA/2 were incubated with vaccinia virus-infected and non-infected 51Cr-labeled ...
Alkan, Boyum, Brunner, Calder, Cohen, Epstein, Evans, Fulginiti, Gardner, Gardner, Glasgow, Good, Hecht, Janossy, Julius, Koszinowski, Labowskie, Lohmann-Mathes, Lundstedt, Marker, McFarland, Oldstone, Perlmann, Perlmann, Profitt, Schirrmacher, Shearer, Shortman, Speel, Steele, Ueda, Ueda, Von Pirquet, Wagner, Wagner, Zinkernagel, Zinkernagel   +36 more
core   +1 more source

Clinical significance of plasmacytoid dendritic cells and myeloid-derived suppressor cells in melanoma [PDF]

, 2015
Background: Immune markers in the peripheral blood of melanoma patients could provide prognostic information. However, there is currently no consensus on which circulating cell types have more clinical impact.
Bachert, Claus, Brochez, Lieve, CHEVOLET, INES, Krysko, Olga, Neyns, Bart, Schreuer, Max, Speeckaert, Reinhart, van Geel, Nanja, Van Gele, Mireille   +8 more
core   +2 more sources

Next-Generation Immunotherapies to Improve Anticancer Immunity

Frontiers in Pharmacology, 2021
Checkpoint inhibitors are widely used immunotherapies for advanced cancer. Nonetheless, checkpoint inhibitors have a relatively low response rate, work in a limited range of cancers, and have some unignorable side effects.
Yaoyao Shi, Katarzyna Tomczak, June Li, Joshua K. Ochieng, Younghee Lee, Cara Haymaker   +5 more
doaj   +1 more source

T-cell cytotoxicity in the absence of viral protein synthesis in target cells [PDF]

, 1977
CYTOTOXIC T cells lyse only those virus infected target cells in vitro which express, in addition to the viral antigen(s), those K or D region products of the major histocompati-bility complex (MHC) which were present during anti-viral sensitisation in ...
A Munro, A Scheid, BH Sandford, BK Ray, D Aminoff, F Garrido, GI Ada, H Ertl, ID Gardner, J Neff, J Salk, M. J. GETHING, M. WATERFIELD, U Koszinowski, U. KOSZINOWSKI, UK Laemmli, Y Hosaka, Y Ueda, YK Shimizu   +18 more
core   +1 more source

Selection, transmission, and reversion of an antigen-processing cytotoxic T-lymphocyte escape mutation in Human Immunodeficiency Virus Type 1 infection [PDF]

, 2004
Numerous studies now support that human immunodeficiency virus type 1 (HIV-1) evolution is influenced by immune selection pressure, with population studies showing an association between specific HLA alleles and mutations within defined cytotoxic T ...
Allen, T.M., Altfeld, M., Brander, C., Cohen, D.E., Freedberg, K.A., Goulder, P.J.R., John, M., Johnston, M.N., Kalife, E.T., Le Gall, S., Lee, P.K., Lichterfeld, M., Mallal, S.A., Mothe, B.R., O'Sullivan, K.M., Rosenberg, E.S., Sette, A., Strick, D.A., Walker, B.D., Yu, X.G.   +19 more
core   +2 more sources

Cytotoxic T-Cell Immunity to Influenza

New England Journal of Medicine, 1983
In a study designed to determine whether cytotoxic T lymphocytes contribute to immunity against influenza virus infection, we inoculated 63 volunteers intranasally with live unattenuated influenza A/Munich/1/79 virus. Over the next seven days clinical observations were made, and the amount of virus shed was measured.
Mcmichael, A, Gotch, F, Noble, G, Beare, P   +3 more
openaire   +3 more sources

Induction of cytotoxic T-cell response against hepatitis C virus structural antigens using a defective recombinant adenovirus [PDF]

, 1997
A replication-defective recombinant adenovirus (RAd), RAdCMV-CE1, containing core and E1 genes of hepatitis C virus (HCV) was constructed. RAdCMV-CE1 was able to express core and E1 proteins both in mice and human cells.
Borras-Cuesta, F. (Francisco), Bruña-Romero, O. (Oscar), Grace, K. (Ken), Klarke, B. (Berwyn), Lasarte, J.J. (Juan José), Prieto, J. (Jesús), Wilkinson, G. (Gavin)   +6 more
core   +1 more source

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

A Study Of Human T-Cell Lines Generated From Multiple Sclerosis Patients And Controls By Stimulation With Peptides Of Myelin Basic Protein [PDF]

, 1996
We generated T-cell lines from the peripheral blood of controls and of patients with multiple sclerosis (MS) by stimulation with overlapping synthetic peptides representing the entire sequences of all four isoforms of human myelin basic protein (MBP ...
Burns, Burrows, Deibler, Doolan, Doolan, Hillert, Houghten, Inobe, Liblau, M.F. Good, M.P. Pender, Martin, Mor, Ota, P.A Csurhes, P.A. McCombe, Pender, Pette, Pettinelli, Poser, R.A. Houghten, Roth, Sobel, Tsuchida, Turnley, Vandenbark, Voskuhl, Voskuhl, Weber, Wong, Zamvil, Zhang, Zhang   +32 more
core   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, EarlyView.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source