Results 131 to 140 of about 2,965,907 (391)

Supplementary Figure 3 from Direct Presentation of a Melanocyte-Associated Antigen in Peripheral Lymph Nodes Induces Cytotoxic CD8⁺ T Cells

, 2023
Prisca Schuler, Emmanuel Contassot, Magali Irla, Stéphanie Hugues, Olivier Preynat‐Seauve, Friederich Beermann, Alena Donda, L.E. French, Bertrand Huard   +8 more
openalex   +1 more source

Interleukin-10 containing normal human serum inhibits granzyme B release but not perforin release from alloreactive and EBV-specific T cell clones [PDF]

, 2007
Interleukin-10 (IL-10), also known as cytokine synthesis inhibitory factor, has pleiotropic effects in immunoregulation and inflammation. It is capable of inhibiting synthesis of pro-inflammatory cytokines like interferon γ (IFNγ), IL-2, IL-3,
Hideya Sato, Hitoshi Okazaki, Kenji Tadokoro, Masahiro Satake, Motoko Nishimura   +4 more
core   +2 more sources

Peripheral blood TIM-3 positive NK and CD8+ T cells throughout pregnancy : TIM-3/galectin-9 interaction and its possible role during pregnancy [PDF]

, 2014
Problem: The T-cell immunoglobulin and mucin domain (TIM) family is a relatively newly described group of molecules with a conserved structure and important immunological functions. Identification of Galectin-9 as a ligand for TIM-3 has established the
Bogár, Barbara, Farkas, Bálint, Illés, Zsolt, Meggyes, Mátyás, Mikó, Éva, Polgár, Beáta, Szereday, László   +6 more
core   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Harnessing the cytotoxic granule exocytosis to augment the efficacy of T-cell-engaging bispecific antibody therapy

Haematologica
T-cell-engaging bispecific antibody (T-BsAb, also known as BiTE) therapy has emerged as a powerful therapeutic modality against multiple myeloma.
Mika Casey, Carol Lee, Sharon M. Hoyte, Rebecca L. Johnston, Wing Yu Kwok, Soi Cheng Law, Maher K Gandhi, Simon J Harrison, Kyohei Nakamura   +8 more
doaj   +1 more source

Data from CD1d-Restricted T Cells License B Cells to Generate Long-Lasting Cytotoxic Antitumor Immunity <i>In vivo</i>

, 2023
Yeonseok Chung, Byung‐Seok Kim, Yeon‐Jeong Kim, Hyun‐Jeong Ko, Sung‐Youl Ko, Dong‐Hyeon Kim, Chang‐Yuil Kang   +6 more
openalex   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Supplementary Figure 5 from Antigen Presented by Tumors <i>In vivo</i> Determines the Nature of CD8⁺ T-Cell Cytotoxicity

, 2023
Anil Shanker, Alan D. Brooks, Kristen M. Jacobsen, John W. Wine, Robert H. Wiltrout, Hideo Yagita∥, Thomas J. Sayers   +6 more
openalex   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Generation of human tumor-reactive cytotoxic T cells against peptides presented by non-self HLA class I molecules [PDF]

, 1998
Elena Sadovnikova, Louise A. Jopling, Kenneth Soo, Hans J. Stauss   +3 more
openalex   +1 more source