Results 111 to 120 of about 2,965,907 (391)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

The Induction of Dendritic Cell Endoplasmic Reticulum Stress by Irradiated-Tumor Derived Extracellular Vesicles Supports the Adoption of a Pro-Tumor Phenotype [PDF]

, 2020
The Induction of Macrophage Endoplasmic Reticulum Stress by Irradiated-Tumor Derived Extracellular Vesicles Supports the Adoption of a Pro-Tumor Phenotype Sitara Mahmoodi, Depts. of Biology and Chemistry, with Dr. Sarah Golding, Dept.
Mahmoodi, Sitara
core   +1 more source

Therapy of disseminated murine leukemia with cyclophosphamide and immune Lyt-1+,2- T cells. Tumor eradication does not require participation of cytotoxic T cells

Journal of Experimental Medicine, 1985
The ability of noncytolytic Lyt-1+,2- T cells immune to FBL-3 leukemia to effect eradication of disseminated FBL-3 was studied. Adult thymectomized, irradiated, and T-depleted bone marrow-reconstituted (ATXBM) B6 hosts were cured of disseminated FBL-3 by
P. D. Greenberg, D. Kern, M. Cheever
semanticscholar   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Characterization of avian natural killer cells and their intracellular CD3 protein complex [PDF]

, 1994
Natural killer (NK) cell activity appears to be conserved throughout vertebrate development but NK cells have only been well characterized in mammals. Candidate NK cells have been identified in the chicken as cytoplasmic CD3+ and surface T cell receptor (
Anderson, Anderson, Bernot, Bucy, Bucy, Chan, Char, Chen, Chen, Chen, Chen, Chomczynski, Ciccone, Cihak, Coltey, Cooper, Dennert, Guillemot, Göbel, Hori, Hála, Laemmli, Lahti, Lanier, Lanier, Lillehoj, Mingari, Moretta, Myers, Nowak, Ortaldo, Phillips, Phillips, Poggi, Ratcliffe, Ritz, Rodewald, Schauenstein, Schnetzler, Sharma, Sowder, Spurr, Suzuki, Terry, Tjoelker, Trinchieri, Voss, Vujanovic, Wilson   +48 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Type I IFNs contribute to upregulation of PD-L1 during Chlamydia trachomatis infection

Infection and Immunity
Chlamydia trachomatis is an obligate intracellular bacterial pathogen that if left untreated can cause reproductive harm. Failure of natural adaptive immunity results in chronic and repeat infections.
Nicole V. Reinhold-Larsson, Michael N. Starnbach   +1 more
doaj   +1 more source

155 MHC class I antigen presentation is associated with an inflamed SCLC tumor microenvironment characterized by a higher density of cytotoxic T-cells in closer proximity to tumor cells [PDF]

, 2022
Miljenka Vuko, Mingchao Xie, Monica Azqueta Gavaldon, Felix Segerer, Andreas Spitzmüller, Harald Hessel, Marco Testori, Johannes Zimmermann, Michael Surace, Mari Heininen-Brown, Jaime Rodriguez Canales, Shashank Saran, Helen Angell, Günter Schmidt, Hadassah Sade, J Carl Barrett, Markus Schick, Giulia Fabbri   +17 more
openalex   +1 more source

Functional characterization of infiltrating T lymphocytes in human hepatic allografts [PDF]

, 1986
We have employed recently developed techniques in T-cell culturing to study the nature and function of infiltrating hepatic allograft T cells. Using the rationale that intragraft T cells are activated during cell mediated damage to the allograft, we were
Adriana Zeevi, Ascher, Bernard, Bono, Brodsky, Brodsky, Brodsky, Burdick, Burdick, Cerilli, Depper, Fiche, Goyert, HancocK, Harty, Hayry, Hoshinaga, Houssin, Iwatsuki, Iwatsuki, Iwatsuki, Jake Demetris, Jeannet, John J. Fung, Kim, Kolbeck, Lampson, Marboe, Mayer, Moreau, Palacios, Paradis, Pober, Rene J. Duquesnoy, Roberts, Shaw, Shunzaburo Iwatsuki, Snover, Spits, Starzl, Steinmuller, Stelzer, Strassman, Thomas E. Starzl, Thompson, Thorley-Lawson, Tilney, van Es, Weintraub, Zeevi, Zeevi, Zeevi, Zeevi, Zeevi   +53 more
core   +1 more source

Clone-specific T cell receptor antagonists of major histocompatibility complex class I-restricted cytotoxic T cells

Journal of Experimental Medicine, 1993
A previous report showed that the proliferative response of helper T cells to class II major histocompatibility complex (MHC)-restricted antigens can be inhibited by analogues of the antigen, which act as T cell receptor (TCR) antagonists. Here we define
S. C. Jameson, F. R. Carbone, M. J. Bevan   +2 more
semanticscholar   +1 more source