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Herpesvirus-transformed cytotoxic T-cell lines
Nature, 1981Investigations of cellular cytotoxicity of the immune system are hampered by the lack of continuously growing, transformed cell lines which express a cytotoxic potential. Here we describe cytotoxic cell lines from the cotton-topped marmoset monkey, transformed by Herpesvirus Ateles (HVA) or Herpesvirus Saimiri (HVS), which can kill certain target cells
D R, Johnson, M, Jondal
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Enumeration of specific cytotoxic T cells
Nature, 1976EFFORTS directed towards the enumeration of effector cells involved in the cell-mediated immune response have so far met with little success. One of the principal reasons for this failure is the current ignorance of relationships between killer, lymphokine producer and suppressor T cells, all of which have effector functions.
Thorn, R M, Henney, C S
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Cytotoxic T cells in teleost fish
Developmental & Comparative Immunology, 2011The presence of antigen-specific cytotoxic T cells has been suggested in a number of in vivo and in vitro studies in fish. Acute allograft rejection with an accelerated response on second-set grafts and the presence of graft-versus-host reaction (GVHR) has been reported in teleost. Alloantigen- and virus-specific cytotoxicity has also been demonstrated
Teruyuki, Nakanishi +3 more
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Clonal Cytotoxic T Cells in Myeloma
Leukemia & Lymphoma, 2003Multiple myeloma (MM) is a malignant disease characterized by accumulation of morphologically recognizable plasma cells producing immunoglobulin (Ig) in the bone marrow. The occurrence of clonal T cells in MM, as defined by the presence of rearrangements in the T-cell receptor (TCR)-beta chains detected on Southern blotting, is associated with an ...
Daniel M Y, Sze +8 more
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Aspects of Cytotoxic T Cell Memory
Immunological Reviews, 1996Immunological T cell memory manifest itself in an accelerated second-set graft, or allogeneic tumour cell, rejection. Memory viral-immune cytotoxic T cells have shortened kinetics of induction in vivo and differentiate into more potent effector cells in vitro.
A, Müllbacher, K, Flynn
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1993
Mechanistically T-cell mediated cytotoxicity uses two pathways for the destruction of a target cell. One is directed at the target membrane and the other at the target nucleus and DNA. These pathways often operate together and at least partially overlap by their common usage of perforin. Perforin mediates direct target membrane damage by pore formation
E. R. Podack +9 more
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Mechanistically T-cell mediated cytotoxicity uses two pathways for the destruction of a target cell. One is directed at the target membrane and the other at the target nucleus and DNA. These pathways often operate together and at least partially overlap by their common usage of perforin. Perforin mediates direct target membrane damage by pore formation
E. R. Podack +9 more
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Continuous Cytotoxic T-Cell Lines
1980Recently, it was reported that it was possible to maintain normal human T lymphocytes in continuous exponential proliferative culture with the aid of a T-cell growth factor (TCGF) derived from lectin-stimulated peripheral blood mononuclear cells (Morgan et al., 1976; Ruscetti et al., 1977). Subsequently, we (Gillis and Smith, 1977; Gillis et al., 1978a;
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Cytotoxic T cell function in fish
Developmental & Comparative Immunology, 2002Fish possess immunoglobulins, major histocompatibility complex (MHC), T-cell receptors, and lymphocyte populations analogous to B and T cells and can evoke specific immune responses against a variety of antigens. However, T-cell subsets have yet to be demonstrated and the information on cell-mediated immunity is limited.
T, Nakanishi +6 more
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Fas-Based T Cell-Mediated Cytotoxicity
1995Phenomenological studies on T cell-mediated cytotoxicity in vitro have been extensively reviewed (Perlmann and Holm 1969; Cerottini and Brunner 1974; Golstein and Smith 1977; Henney 1977; Martz 1977; Berke 1980; Sanderson 1981; Henkart 1985; Berke 1989a; Young 1989; Tschopp and Nabholz 1990; Duke 1991; Golstein et al. 1991; Sitkovsky and Henkart 1993).
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Integrative oncology: Addressing the global challenges of cancer prevention and treatment
Ca-A Cancer Journal for Clinicians, 2022Jun J Mao,, Msce +2 more
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