Results 11 to 20 of about 733,847 (374)
Neuroinflammation by cytotoxic T-lymphocytes impairs retrograde axonal transport in an oligodendrocyte mutant mouse [PDF]
PLoS ONE, 2012 Mice overexpressing proteolipid protein (PLP) develop a leukodystrophy-like disease involving cytotoxic, CD8+ T-lymphocytes. Here we show that these cytotoxic T-lymphocytes perturb retrograde axonal transport.
Antje Kroner +11 more
core +7 more sources
Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations [PDF]
Haematologica, 2012 Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies.
Bryceson, Yenan T. +7 more
core +3 more sources
Adoptive cancer immunotherapy using DNA-demethylated T helper cells as antigen-presenting cells [PDF]
Nature Communications, 2018 A critical determinant of tumor eradication by adoptive immunotherapy is the tumor associated antigen recognized by cytotoxic T lymphocytes. Here the authors generate ex vivo autologous cytotoxic T lymphocytes by exposure to antigens induced by DNA ...
Andersen, Rikke S +16 more
core +4 more sources
Perforin, granzyme B, and FasL expression by peripheral blood T lymphocytes in emphysema [PDF]
Respiratory Research, 2007 Background It is generally accepted that emphysematous lungs are characterized by an increase in the numbers of neutrophils, macrophages, and CD8+ T lymphocytes, the lasts having increased cytotoxic activity.
A Bas +31 more
core +5 more sources
Resistance of cytotoxic T lymphocytes to lysis by a clone of cytotoxic T lymphocytes. [PDF]
Proceedings of the National Academy of Sciences, 1987 To investigate how cytotoxic T lymphocytes (CTL) avoid killing themselves when they destroy target cells, we compared 20 different cell lines as target cells, including several CTL cell lines, for their susceptibility to lysis by CTL. Variations in recognition of this diverse set of target cells was circumvented by attaching to all of them a monoclonal
David M. Kranz, Herman N. Eisen
openaire +3 more sources
Cytotoxic T lymphocytes could contribute in COVID-19-induced passing anosmia
Studia Medyczne, 2021 Several clinical reports have demonstrated a spectrum of neurological manifestations of COVID-19 patients with subsequent post-mortem neuropathological findings. The aim of the case description is to show spotty inflammatory lesions in the olfactory bulb,
Marcin Zaremba +2 more
doaj +1 more source
High Glucose Enhances Cytotoxic T Lymphocyte-Mediated Cytotoxicity [PDF]
Frontiers in Immunology, 2021 Cytotoxic T lymphocytes (CTLs) are key players to eliminate tumorigenic or pathogen-infected cells using lytic granules (LG) and Fas ligand (FasL) pathways. Depletion of glucose leads to severely impaired cytotoxic function of CTLs. However, the impact of excessive glucose on CTL functions still remains largely unknown.
Jie Zhu +19 more
openaire +6 more sources
Cytotoxic Granule Trafficking and Fusion in Synaptotagmin7-Deficient Cytotoxic T Lymphocytes
Frontiers in Immunology, 2020 Granules of cytotoxic T lymphocytes (CTL) are derived from the lysosomal compartment. Synaptotagmin7 (Syt7) appears to be the calcium sensor triggering fusion of lysosomes in fibroblasts. Syt7 has been proposed to control cytotoxic granule (CG) fusion in
Marwa Sleiman +3 more
doaj +1 more source
Медицинская иммунология, 2020 We studied sex differences lymphocytes subpopulations of peripheral blood in adult C57Bl/6 mice during acute and chronic colitis, induced with 1% DSS. We measured subpopulations of lymphocytes with flow cytometry.
O. V. Makarova +3 more
doaj +1 more source
Healthy aging—would cytotoxic T lymphocytes stand out?
Cell Death Discovery, 2023 Senescent cells (SnCs) accumulate in multiple tissue types with the process of individual aging, hindering tissue renewal and driving multiple aging-related disorders.
Tianyu Zhang, Jinjin Zhang, Shixuan Wang
doaj +1 more source