Results 191 to 200 of about 906,600 (363)

The Influence of Indisulam on Human Immune Effector Cells: Is a Combination with Immunotherapy Feasible?

Pharmaceutics
Background: As a modulator of pre-mRNA splicing, the anti-cancer agent indisulam can induce aberrantly spliced neoantigens, enabling immunologic anti-tumor activity. Consequently, combining indisulam with immunotherapy is expected to be a promising novel
Lisa Arnet, Lisabeth Emilius, Annett Hamann, Maria Carmo-Fonseca, Carola Berking, Jan Dörrie, Niels Schaft   +6 more
doaj   +1 more source

The use of cyclosporin A and prednisone in cadaver kidney transplantation [PDF]

, 1980
Eighteen patients were treated with primary cadaveric renal transplantation using cyclosporin A therapy, and four more patients underwent cadaveric retransplantation.
Iwaki, Y, Iwatsuki, S, Klintmalm, G, Koep, LJ, Porter, KA, Schröter, GP, Starzl, TE, Terasaki, PI, Weil, R   +8 more
core  

Identification of immunological genes important for cytotoxicity

, 2019
Natural Killer (NK) cells and Cytotoxic T lymphocytes (CTLs) are essential to defend the body against foreign or transformed cells. An understanding of the mechanism of their cytotoxicity can result in the generation of genetically modified cells with higher cytotoxicity and to identify drug-targets that increase cytotoxicity.
openaire   +1 more source

Implantable Microarray Patch: Engineering at the Nano and Macro Scale for Sustained Therapeutic Release via Synthetic Biodegradable Polymers

Advanced Materials Technologies, Volume 10, Issue 6, March 18, 2025.
This review focuses on the application of synthetic biodegradable microarray patches (MAPs) in sustained drug delivery. Compared to conventional MAPs which release drugs into the skin in an immediate manner, these implantable MAPs release drugs into skin microcirculation gradually as the biodegradable polymers degrade, thus offering sustained release ...
Li Zhao, Akmal Hidayat Bin Sabri, Mary B. McGuckin, Linlin Li, Zihao Wang, Eneko Larrañeta, Ryan F. Donnelly   +6 more
wiley   +1 more source

A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose

npj Vaccines
Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global ...
Christina A. Rostad, Inci Yildirim, Carol Kao, Jumi Yi, Satoshi Kamidani, Etza Peters, Kathleen Stephens, Theda Gibson, Hui-Mien Hsiao, Karnail Singh, Paul Spearman, Courtney McCracken, Vivien Agbakoba, Kay M. Tomashek, Johannes B. Goll, Casey E. Gelber, Robert A. Johnson, Sujin Lee, Kristal Maner-Smith, Steven Bosinger, Eric A. Ortlund, Xuemin Chen, Larry J. Anderson, Jens Wrammert, Mehul Suthar, Nadine Rouphael, Evan J. Anderson   +26 more
doaj   +1 more source

Integrating electromagnetic cancer stress with immunotherapy: a therapeutic paradigm

Frontiers in Oncology
An array of published cell-based and small animal studies have demonstrated a variety of exposures of cancer cells or experimental carcinomas to electromagnetic (EM) wave platforms that are non-ionizing and non-thermal.
Mark M. Fuster, Mark M. Fuster, Mark M. Fuster, Mark M. Fuster   +3 more
doaj   +1 more source

The influence of season, photoperiod, and pineal melatonin on immune function. [PDF]

, 1995
In addition to the well-documented seasonal cycles of mating and birth, there are also significant seasonal cycles of illness and death among many animal populations.
Demas, G, Klein, S, Kriegsfeld, Lance, Nelson, R   +3 more
core   +1 more source

Accelerated Bone Healing via Electrical Stimulation

Advanced Science, EarlyView.
Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun, Wenqing Xie, Yuxiang Wu, Zhou Li, Yusheng Li   +4 more
wiley   +1 more source

Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage

Advanced Science, EarlyView.
Exosome‐based nanoparticles (GC‐Exo‐CD16Ab) are designed to deliver glucocorticoids (GC) specifically to decidual CD16+ NK cells and macrophages. This targeted delivery effectively suppresses the cytotoxicity of decidual NK cells, inhibits M1 macrophage polarization, and modulates the decidual microenvironment.
Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin   +17 more
wiley   +1 more source

Polydopamine Nanohydrogel Decorated Adhesive and Responsive Hierarchical Microcarriers for Deafness Protection

Advanced Science, EarlyView.
A type of polydopamine (PDA) nanogel decorated adhesive and responsive hierarchical microcarriers for ALA delivery and deafness prevention. PDA@microcarriers can protect the encapsulated drugs from external disturbances and prolong their retention time in the inner ear.
Hong Chen, Hui Zhang, Jiayi Li, Xianmei Wei, Chenjie Yu, Yuanjin Zhao, Maoli Duan, Xiaoyun Qian, Xia Gao   +8 more
wiley   +1 more source