Results 21 to 30 of about 937,918 (334)
Cancer Research, 2018 Elucidation of the underlying molecular mechanisms of immune evasion in cancer is critical for the development of immunotherapies aimed to restore and stimulate effective antitumor immunity.
Antoun Al Absi +14 more
semanticscholar +1 more source
Immunological Changes after Cancer Treatment and Participation in an Exercise Program [PDF]
, 2003 Purpose: The purpose of this investigation was to evaluate the impact of undertaking peripheral blood stem cell transplantation (PBST) on T-cell number and function, and to determine the role of a mixed type, moderate intensity exercise program in ...
Andrykowski +27 more
core +2 more sources
Lung tumor microenvironment induces specific gene expression signature in intratumoral NK cells
Frontiers in Immunology, 2013 Natural Killer (NK) cells are able to recognize and kill tumor cells, however whether they contribute to tumor immunosurveillance is still debated. Our previous studies demonstrated the presence of NK cells in human lung tumors.
Mélanie eGillard-Bocquet +22 more
doaj +1 more source
Exploiting the neoantigen landscape for immunotherapy of pancreatic ductal adenocarcinoma [PDF]
, 2016 Immunotherapy approaches for pancreatic ductal adenocarcinoma (PDAC) have met with limited success. It has been postulated that a low mutation load may lead to a paucity of T cells within the tumor microenvironment (TME).
Alvarez, Hector A. +13 more
core +1 more source
Cytotoxic and Immunologic Effects of Methotrexate in Psoriasis
Journal of Investigative Dermatology, 1990 Based on recent experience that Cyclosporin A, an immunosuppressive drug, produces marked improvement in psoriasis, possible immunomodulatory activities of methotrexate (MTX) have been reviewed to look for alternate mechanisms of MTX action in psoriasis. It is generally considered that the therapeutic results of MTX in psoriasis are related to a direct
Weinstein, Gerald D. +2 more
openaire +2 more sources
Cx43-Gap Junctions Accumulate at the Cytotoxic Immunological Synapse Enabling Cytotoxic T Lymphocyte Melanoma Cell Killing [PDF]
International Journal of Molecular Sciences, 2019 Upon tumor antigen recognition, cytotoxic T lymphocytes (CTLs) and target cells form specialized supramolecular structures, called cytotoxic immunological synapses, which are required for polarized delivery of cytotoxic granules. In previous reports, we described the accumulation of connexin 43 (Cx43)-formed gap junctions (GJs) at natural killer (NK ...
Francisca Hofmann +6 more
openaire +2 more sources
Iranian Journal of Allergy, Asthma and Immunology, 2019 Stromal cell-derived factor-1 alpha (SDF-1α) has been shown to be up-regulated in a variety of malignancies. So that, its expression is associated with poor prognosis and invasiveness.
Alireza Mardomi +4 more
doaj +1 more source
Cytotoxicity of Reparative Endodontic Cements on Human Periodontal Ligament Stem Cells
Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022 Objective: To compare the cytotoxicity of commercial reparative endodontic cements on human periodontal ligament stem cells (hPDLSCs). Material and Methods: The culture of hPDLSCs was established.
Marlus da Silva Pedrosa +4 more
doaj
Tim-3 Is Upregulated in NK Cells during Early Pregnancy and Inhibits NK Cytotoxicity toward Trophoblast in Galectin-9 Dependent Pathway. [PDF]
PLoS ONE, 2016 NK cells accumulate at the maternal-fetal interface (MFI) and play essential roles in maintaining immune tolerance during pregnancy. The mechanisms that facilitate NK cells tolerance to fetal tissue are largely unknown.
Jintang Sun +9 more
doaj +1 more source
Evidence-Based Complementary and Alternative Medicine, 2018 Lycium barbarum polysaccharide (LBP) is the major function component of Lycium barbarum L. and has been previously reported to induce the phenotypic and functional maturation of dendritic cells (DCs) as well as activating T lymphocytes.
W. Wang +8 more
semanticscholar +1 more source