Results 41 to 50 of about 241,206 (292)

Optimization of self-nano emulsifying drug delivery system of rifampicin for nebulization using cinnamon oil as oil phase

Pharmaciana
Lung delivery can overcome the problems related to the effectiveness of tuberculosis treatment by increasing the drug concentration at the target site. Rifampicin as the first-line antibiotic for tuberculosis has low water solubility and is unstable in ...
I Komang Aan Adi Ricardo, Dewa Ayu Arimurni   +1 more
doaj   +1 more source

Optimisation of nutritional composition of traditional porridges produced from blended pearl millet, cowpeas, and wild loquat and velvet wild medlar fruits

Food Chemistry Advances, 2023
Traditional cereal based porridges have an important role to play in the fight against food insecurity. However, the cereal based porridges are high in energy and are usually deficient in some essential amino acids as well as micronutrients.
G Mujinda, S Manhokwe, A Chawafambira, D.T. Mugadza, D.T. Chagwena, T.Z. Jombo   +5 more
doaj   +1 more source

A cochleate formulation optimized by D-optimal mixture design enhances oral bioavailability of Revaprazan

Journal of Liposome Research, 2023
A cochleate formulation was developed to enhance the oral bioavailability of revaprazan (RVP). Dimyristoyl phosphatidylcholine (DMPC) liposome containing dicetyl phosphate (DCP) successfully formed a cochleate after treatment with CaCl2, whereas that containing sodium deoxycholate did not.
Yoon Tae, Goo, Min Song, Kim, Ji Yeh, Choi, Gi Hyeong, Sin, Sun Ho, Hong, Chang Hyun, Kim, Young Wook, Choi   +6 more
openaire   +2 more sources

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Optimasi HPMC K15M, Karbopol 940, dan Propilen Glikol pada Formula Nanoemulgel Naringenin Metode D-Optimal Mixture Design

, 2022
Naringenin is a flavanone from citrus fruit which has antioxidant activity which has low bioavailability in water. The way to increase the bioavailability of naringenin is to create a SNEDDS delivery system. Nanoemulsion preparations are considered to be
Hidayati, Rakhmi, Kuncahyo, Ilham, Saptarini, Opstaria   +2 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Optimization of spicy red pepper paste (Awaze) formulation by D‐optimal mixture design

Food Science & Nutrition, 2023
AbstractThe aim of this study was to produce spicy red pepper paste (Awaze) by addition of various sources of antioxidant, mineral, and fiber and optimize better processing methods of the paste. For this purpose, D‐optimal mixture design was used, Awaze considering color value (a*), antioxidant content, mineral content, fiber content, chewiness, and ...
Kefale Biadge, Mulugeta Admasu Delele, Solomon Workneh Fanta, Abate Mekonnen Solomon   +3 more
openaire   +2 more sources

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

USE D-OPTIMAL MIXTURE DESIGN IN FORMULATION OF ONCHIDIID SLUG (ONCHIDIUM TYPHAE) INSTANT POWDER AS FUNCTIONAL FOODS

Jurnal Farmasi Sains dan Praktis
Onchidiid slug (Onchidium typhae) is an animal with bioactive compounds with high nutritional value and the potential to be used as a functional food product.
Bambang Wijianto, Tendianus Tendianus, Liza Pratiwi   +2 more
doaj   +1 more source