Predictive value of serum d-serine level for hearing impairment in uremic patients [PDF]
Renal Failure, 2023 Objective To investigate the predictive value of serum d-serine level for hearing impairment (HI) in uremic patients.Methods In this study, 30 uremic patients with HI and 30 with normal hearing were selected. The basic conditions, biochemical indicators,
Jiaqing Li +6 more
doaj +2 more sources
D-Serine: A Cross Species Review of Safety [PDF]
Frontiers in Psychiatry, 2021 Background:D-Serine, a direct, full agonist at the D-serine/glycine modulatory site of the N-methyl-D-aspartate-type glutamate receptors (NMDAR), has been assessed as a treatment for multiple psychiatric and neurological conditions.
Amir Meftah +5 more
doaj +2 more sources
Astrocytes control hippocampal synaptic plasticity through the vesicular-dependent release of D-serine [PDF]
Frontiers in Cellular Neuroscience, 2023 Astrocytes, the most abundant glial cells in the central nervous system (CNS), sense synaptic activity and respond through the release of gliotransmitters, a process mediated by intracellular Ca2+ level changes and SNARE-dependent mechanisms.
Daniela Sofia Abreu +11 more
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ASC Transporters Mediate D-Serine Transport into Astrocytes Adjacent to Synapses in the Mouse Brain [PDF]
Biomolecules, 2023 D-serine is an important signalling molecule, which activates N-methyl D-aspartate receptors (NMDARs) in conjunction with its fellow co-agonist, the neurotransmitter glutamate.
Karthik Subramanian Krishnan +1 more
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Regional contributions of D-serine to Alzheimer’s disease pathology in male AppNL–G–F/NL–G–F mice [PDF]
Frontiers in Aging Neuroscience, 2023 BackgroundNeurodegenerative processes in Alzheimer’s disease (AD) are associated with excitotoxicity mediated by the N-methyl-D-aspartate receptor (NMDAR). D-Serine is an endogenous co-agonist necessary for NMDAR-mediated excitotoxicity. In the mammalian
Xiance Ni +19 more
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The effects of the NMDAR co-agonist d-serine on the structure and function of optic tectal neurons in the developing visual system [PDF]
Scientific Reports, 2023 The N-methyl-d-aspartate type glutamate receptor (NMDAR) is a molecular coincidence detector which converts correlated patterns of neuronal activity into cues for the structural and functional refinement of developing circuits in the brain.
Zahraa Chorghay +4 more
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Chronic d-serine supplementation impairs insulin secretion
Molecular Metabolism, 2018 Objective: The metabolic role of d-serine, a non-proteinogenic NMDA receptor co-agonist, is poorly understood. Conversely, inhibition of pancreatic NMDA receptors as well as loss of the d-serine producing enzyme serine racemase have been shown to ...
Lisa Suwandhi +21 more
doaj +7 more sources
D-serine increases adult hippocampal neurogenesis [PDF]
Frontiers in Neuroscience, 2013 Adult hippocampal neurogenesis results in the continuous formation of new neurons and is a process of brain plasticity involved in learning and memory. The neurogenic niche regulates the stem cell proliferation and the differentiation and survival of new
Sebastien eSultan +3 more
doaj +5 more sources
Excitatory and inhibitory D-serine binding to the NMDA receptor [PDF]
eLife, 2022 N-methyl-D-aspartate receptors (NMDARs) uniquely require binding of two different neurotransmitter agonists for synaptic transmission. D-serine and glycine bind to one subunit, GluN1, while glutamate binds to the other, GluN2.
Remy A Yovanno +4 more
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d-Serine Inhibits Non-ionotropic NMDA Receptor Signaling. [PDF]
J NeurosciNMDA-type glutamate receptors (NMDARs) are widely recognized as master regulators of synaptic plasticity, most notably for driving long-term changes in synapse size and strength that support learning. NMDARs are unique among neurotransmitter receptors in that they require binding of both neurotransmitter (glutamate) and co-agonist (
Barragan EV +10 more
europepmc +8 more sources