Results 11 to 20 of about 544,097 (279)
The role of D-serine in peripheral tissues [PDF]
European Journal of Pharmacology, 2016 A considerable level of D-serine (a free D-amino acid) was discovered, surprisingly, in the mammalian brain in the early 1990s. Since then, D-serine has been considered to be a co-agonist of glutamate at the glycine site of NMDA receptors. D-serine is synthetized by racemization of L-serine in most neural and non-neural cells, and modulates a variety ...
Camila, Montesinos Guevara, Ali R, Mani
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The role of D-serine and glycine as co-agonists of NMDA receptors in motor neurone degeneration and amyotrophic lateral sclerosis (ALS) [PDF]
Frontiers in Synaptic Neuroscience, 2014 The fundamental role of D-serine as a co-agonist at the N-methyl-D-aspartate receptor (NMDAR), mediating both physiological actions of glutamate in long term potentiation and nociception and also pathological effects mediated by excitotoxicty, are well ...
Praveen ePaul, Jackie ede Belleroche
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An Overview of the Involvement of D-Serine in Cognitive Impairment in Normal Aging and Dementia [PDF]
Frontiers in Psychiatry, 2021 Dementia, of which Alzheimer's disease (AD) is the most common form, is characterized by progressive cognitive deterioration, including profound memory loss, which affects functioning in many aspects of life.
Magdalena Orzylowski +6 more
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Serum d-serine and d-amino acid oxidase (DAO) levels in schizophrenia and related psychotic disorders: a 6-month follow-up study [PDF]
European PsychiatryIntroduction D-serine and the DAO enzyme may impact the NMDA receptor and contribute to schizophrenia, but the exact role and outcomes are not fully understood due to the complexity of the disorder. Objectives We analyzed serum levels of d-serine and
E. Uzun Uysal +3 more
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D-3-Phosphoglycerate Dehydrogenase [PDF]
Frontiers in Molecular Biosciences, 2018 l-Serine is the immediate precursor of d-serine, a major agonist of the N-methyl-d-aspartate (NMDA) receptor. l-Serine is a pivotal amino acid since it serves as a precursor to a large number of essential metabolites besides d-serine.
Gregory A. Grant, Gregory A. Grant
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Corrigendum: D-serine contributes to seizure development via ERK signaling [PDF]
Frontiers in NeuroscienceTie Ma +8 more
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Frontiers in Psychiatry, 2021 A core symptom that is frequently linked with dysregulation of glutamatergic neurotransmission in regard to schizophrenia is impairment or damage of executive functioning as a component of cognitive deficiency.
Jaromir Hons +10 more
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Separation and detection of D-/L-serine by conventional HPLC
MethodsX, 2022 D-serine has a role as an endogenous allosteric agonist of N-methyl-D-aspartate (NMDA) receptor in the mammalian brain. In this study, we present a detailed description of our method that measures D-/L-serine by using conventional high performance liquid
Hiroki Shikanai +5 more
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Molecular Medicine, 2021 Objective d-Serine is a crucial endogenous co-agonist of N-methyl-d-aspartate receptors (NMDARs) in the central nervous system and can affect the function of the brain derived neurotrophic factor (BDNF) system, which plays an essential role in modulating
Zhenzhen Chen +6 more
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Cells, 2021 Insulin-secreting pancreatic β-cells express proteins characteristic of D-serine regulated synapses, but the acute effect of D-serine co-agonism on its presumptive β-cell target, N-methyl D-aspartate receptors (NMDARs), is unclear.
Amber Lockridge +4 more
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